Zobrazeno 1 - 10
of 98
pro vyhledávání: '"John A Calarco"'
Autor:
Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular conv
Externí odkaz:
https://doaj.org/article/091429a4162845e7a18371f487596c6f
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3089-3101 (2017)
Neuromodulatory cells transduce environmental information into long-lasting behavioral responses. However, the mechanisms governing how neuronal cells influence behavioral plasticity are difficult to characterize. Here, we adapted the translating rib
Externí odkaz:
https://doaj.org/article/0b1bdfeea47c40259537997aaed57918
Autor:
Kyung Suk Lee, Shachar Iwanir, Ronen B. Kopito, Monika Scholz, John A. Calarco, David Biron, Erel Levine
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Regulating food intake is an important physiological mechanism. Here, the authors use a custom microfluidic device to investigate feeding dynamics inC. elegans, and identify roles of serotonergic neurons in regulating bursts of feeding in response to
Externí odkaz:
https://doaj.org/article/eac0a957a6d24619b1ca95b99c87377c
Publikováno v:
eLife, Vol 8 (2019)
Single-cell transcriptomes are established by transcription factors (TFs), which determine a cell's gene-expression complement. Post-transcriptional regulation of single-cell transcriptomes, and the RNA binding proteins (RBPs) responsible, are more t
Externí odkaz:
https://doaj.org/article/693d9901788f4ee597a4c972cb15372c
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2537
Alternative splicing is a key layer of gene regulation that is frequently modulated in a spatiotemporal manner. As such, it is a major goal to understand the mechanisms controlling alternative splicing in specific cellular contexts. Reporters that re
Autor:
Nathan Harris, Samuel Bates, Zihao Zhuang, Matthew Bernstein, Jamie Stonemetz, Tyler Hill, Yanxun V. Yu, John A. Calarco, Piali Sengupta
Publikováno v:
Current Biology. 33:1487-1501.e7
Neurons modify their transcriptomes in response to an animal’s experience. How specific experiences are transduced to modulate gene expression and precisely tune neuronal functions are not fully defined. Here, we describe the molecular profile of a
Publikováno v:
eLife, Vol 6 (2017)
Genetic interaction screens have aided our understanding of complex genetic traits, diseases, and biological pathways. However, approaches for synthetic genetic analysis with null-alleles in metazoans have not been feasible. Here, we present a CRISPR
Externí odkaz:
https://doaj.org/article/df71ec85f2854922b915243b0cdc4528
Autor:
Maria Lim, Jyothsna Chitturi, Valeriya Laskova, Jun Meng, Daniel Findeis, Anne Wiekenberg, Ben Mulcahy, Linjiao Luo, Yan Li, Yangning Lu, Wesley Hung, Yixin Qu, Chiyip Ho, Douglas Holmyard, Ni Ji, Rebecca D McWhirter, Aravinthan DT Samuel, David M Miller, Ralf Schnabel, John A Calarco, Mei Zhen
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/f13f653a2ac84561bbbf4787b6e3ac1b
Autor:
Maria A Lim, Jyothsna Chitturi, Valeriya Laskova, Jun Meng, Daniel Findeis, Anne Wiekenberg, Ben Mulcahy, Linjiao Luo, Yan Li, Yangning Lu, Wesley Hung, Yixin Qu, Chi-Yip Ho, Douglas Holmyard, Ni Ji, Rebecca McWhirter, Aravinthan DT Samuel, David M Miller, Ralf Schnabel, John A Calarco, Mei Zhen
Publikováno v:
eLife, Vol 5 (2016)
Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family
Externí odkaz:
https://doaj.org/article/c0026a7e9a464144a519fe9c6f281fee
Autor:
Charlotte J, Martin, John A, Calarco
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2468
The clustered, regularly interspaced, short, palindromic repeat (CRISPR)-associated (CAS) nuclease Cas9 has been used in many organisms to generate specific mutations and transgene insertions. Here we describe our most up-to-date protocols using the