Výsledky vyhledávání - "John A Brinkman"

Clinical and Metabolic Correlates of Pure Stone Subtypes

Autor: Christa L. Stoughton, John E. Brinkman, Amy E. Krambeck, Charles U. Nottingham, Tim Large

Publikováno v: Journal of endourology. 35(10)

Background: There are multiple stone types, with each forming under different urinary conditions. We compared clinical and metabolic findings in pure stone formers (SFs) to understand whether there...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9b1de081971baefc0eb9747312e832
https://pubmed.ncbi.nlm.nih.gov/33573466

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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists

Autor: Rachid Hamid, Roger David Norcross, Mary Lou Gubler, Ramakanth Sarabu, Fariborz Firooznia, Adrian Wai-Hing Cheung, John A. Brinkman, Nicholas Marcopulos, Lida Qi, Kevin Richard Guertin, Alexander Flohr, Jenny Tan, Gwendolyn Ramsey, Joseph Grimsby, Yang Wen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:4140-4146

7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A(2B) receptor antagonists because of its slight selectivity against A(1) and A(2A) recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2103d066fa21cacca11962d6d1f7caf
https://doi.org/10.1016/j.bmcl.2010.05.056

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NEUROPSYCHOLOGICAL MEASURES AND SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN THE DIFFERENTIATION AND CLASSIFICATION OF CEREBRAL PERFUSION DEFICITS IN ALZHEIMER'S DEMENTIA

Autor: Raymond S. Dean, Andrew S. Davis, John J. Brinkman, Mark G. Moren

Publikováno v: International Journal of Neuroscience. 115:1131-1149

The accurate diagnosis of Dementia of the Alzheimer's Type (DAT) continues to be an area of difficulty for the fields of neuropsychology and neurology. The introduction of new medications that appear to mediate the insidious progression of the disord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29de0d9843f58ac9990e965178f58c57
https://doi.org/10.1080/00207450590914428

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1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Autor: Edwin Bernard Villhauer, Thomas Edward Hughes, John A Brinkman, Manisha Mone, Bonnie L Mangold, Mary E Russell, Goli B Naderi, Stephen Craig Weldon, Beth E. Dunning

Publikováno v: Journal of Medicinal Chemistry. 45:2362-2365

Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. We report the first use of solid-phase synthesis in the discovery of a new DPP-IV inhibitor class and a solution-phase synthesis that is p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a23159d1dca769374d0d90eb53fdcb
https://doi.org/10.1021/jm025522z

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Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine

Autor: Terence J. Scallen, T.R. Vedamanda, John A. Brinkman, Lawerence B. Perez, Fell Jay Bradford, Robert E. Damon

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2491-2494

Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35c5514431de397813b7580cc7fdc7cf
https://doi.org/10.1016/0960-894x(96)00470-2

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Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity

Autor: Rachid Hamid, Mary Lou Gubler, Yang Wen, Nicholas Marcopulos, Ramakanth Sarabu, Joseph Grimsby, Fariborz Firooznia, Jenny Tan, John A. Brinkman, Gwendolyn Ramsey, Adrian Wai-Hing Cheung

Publikováno v: Bioorganicmedicinal chemistry letters. 21(7)

The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A(2B) antagonists, due to its excellent potency, and good drug-like p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ede100796491a883f62581d63589c80
https://pubmed.ncbi.nlm.nih.gov/21388809

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Trifluoromethyl-Substituted Indenyl Rhodium and Iridium Complexes Are Highly Selective Catalysts for Directed Hydroboration Reactions

Autor: John A. Brinkman, John R. Sowa, Tam T. Nguyen

Publikováno v: Organic Letters. 2:981-983

Rhodium and iridium catalysts containing trifluoromethyl-substituted indenyl ligands (Ind'MCod, Ind' = C9H7, (1-CF3)C9H6, (2-CF3)C9H6, (1,3-CF3)2C9H5) have been developed for the directed hydroboration of 4-(benzyloxy)cyclohexene to cis-3-(benzyloxy)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45246cc0a819d5c95647aff29c4d8481
https://doi.org/10.1021/ol005653z

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