Zobrazeno 1 - 10
of 54
pro vyhledávání: '"John A Alberta"'
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
Externí odkaz:
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3167-3177 (2017)
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmenta
Externí odkaz:
https://doaj.org/article/7fb9e82920cf40d1898b5c51de91b9b8
Autor:
Daphne A. Haas-Kogan, Dipanjan Chowdhury, Sabine Mueller, Steven G. DuBois, Keith L. Ligon, Pratiti Bandopadhayay, Adam C. Resnick, William A. Weiss, Nathalene Truffaux, Jie Bian, Kevin X. Liu, Jean Zhao, John A. Alberta, Jing Ni, Whitney Fitts, Wojciech Fendler, Xiaodong Yang, David Kozono, Sharmistha Pal
Aberrant chromatin remodeling and activation of the PI3K pathway have been identified as important mediators of pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) pathogenesis. As inhibition of these pathways are promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6613744958b4ec918a210014d5fcadb9
https://doi.org/10.1158/0008-5472.c.6510390.v1
https://doi.org/10.1158/0008-5472.c.6510390.v1
Autor:
Daphne A. Haas-Kogan, Dipanjan Chowdhury, Sabine Mueller, Steven G. DuBois, Keith L. Ligon, Pratiti Bandopadhayay, Adam C. Resnick, William A. Weiss, Nathalene Truffaux, Jie Bian, Kevin X. Liu, Jean Zhao, John A. Alberta, Jing Ni, Whitney Fitts, Wojciech Fendler, Xiaodong Yang, David Kozono, Sharmistha Pal
This file contains the supplementary figures (S1-S10) with legends and supplementary tables S1-S8. Supplementary Tables S1-S3 contain sequences for siRNA and primers used in RT-PCR, ChIP-PCR. Supplementary Tables S4-S8 contain the p-values for all pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a87b44cc2bc68994eafeff605e9474
https://doi.org/10.1158/0008-5472.22419474.v1
https://doi.org/10.1158/0008-5472.22419474.v1
Autor:
Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 950-966 (2016)
In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown that phospho-OLIG2, a central-nervous
Externí odkaz:
https://doaj.org/article/ad5978bda5ba4c749fa2b28df1ebe0b1
Autor:
Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2410-2412 (2017)
Externí odkaz:
https://doaj.org/article/2afec7982ff047699ffad069f7922f86
Autor:
Kristine Pelton, Prasidda Khadka, Kenin Qian, Zachary T. Herbert, Guillaume Bergthold, Mariella G. Filbin, Liliana Goumnerova, Aviv Regev, Robert T. Jones, John F. Daley, Jessica Weatherbee, Yu Sun, Ying Huang, Keith L. Ligon, Orit Rozenblatt-Rosen, Pratiti Bandopadhayay, Rameen Beroukhim, Claire Sinai, John A. Alberta, Brenton R. Paolella, Alex K. Shalek, Zachary J. Reitman, Sarah Becker, Rosalind A. Segal, Mark W. Kieran, Alexandra L. Condurat, Daphne A. Haas-Kogan, Charles D. Stiles, Hayley Malkin, Leslie Grimmet, Mario L. Suvà
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in six PAs using methods that enabled detection of the rearrangement. When compared to higher-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b70258a1ec545ddf0ff81ff4bb35731
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
John A. Alberta, Charles D. Stiles
Publikováno v:
BioTechniques, Vol 23, Iss 3, Pp 490-493 (1997)
Synthetic tyrosine phosphopeptides were used to generate antibodies that recognize phosphotyrosine in the context of a defined sequence of flanking amino acids. Using phosphopeptide immunogens derived from regulatory or signal-generating motifs, “p
Externí odkaz:
https://doaj.org/article/5e54293335e94a548200ed3ab5a39d09
Autor:
Amelie Griveau, Peter Sicinski, Keith L. Ligon, Jarrod A. Marto, William D. Snider, David H. Rowitch, Wojciech Michowski, Rintaro Hashizume, C. David James, Charles D. Stiles, John A. Alberta, Joseph D. Card, Scott B. Ficarro, Jing Zhou, An-Chi Tien, Yu Sun, Janhavee S. Deshpande, Meghan Morgan-Smith
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3167-3177 (2017)
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0a1b5884c6417a354541f1dc0cca6
http://www.sciencedirect.com/science/article/pii/S2211124717303200
http://www.sciencedirect.com/science/article/pii/S2211124717303200