Zobrazeno 1 - 10
of 64
pro vyhledávání: '"John A, Karas"'
Autor:
Lin Hsin, Nithya A. Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A. Karas, Susan E. Northfield, Graham A. Mackay
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1R). More recently, it has also been shown to activate the Mas‐related G protein‐coupled receptor X2 (MRGPRX2) receptor on mas
Externí odkaz:
https://doaj.org/article/cfb20b206d1349c798868224e851ca6a
Autor:
Qingqing Lin, Denham Hopper, Haoyue Zhang, Jordan Sfyris Qoon, Zihan Shen, John A. Karas, Richard A. Hughes, Susan E. Northfield
Publikováno v:
ACS Omega, Vol 5, Iss 4, Pp 1840-1850 (2020)
Externí odkaz:
https://doaj.org/article/7b076343cc334a9fb7ae82a2758b816a
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs). Unfortunately, ASOs have poor cell membrane permeabilit
Externí odkaz:
https://doaj.org/article/9b889f8496db46f8b5a4867eab1d9869
Autor:
Maytham Hussein, John A. Karas, Elena K. Schneider-Futschik, Fan Chen, James Swarbrick, Olivia K. A. Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from
Externí odkaz:
https://doaj.org/article/4ec53ffd77414313be7feb1fc848292b
Autor:
Rong Xu, Sukhvir Kaur Bhangu, Karly C. Sourris, Domitilla Vanni, Marc‐Antoine Sani, John A. Karas, Karen Alt, Be'eri Niego, Anukreity Ale, Quinn A. Besford, Brendan Dyett, Joshua Patrick, Irena Carmichael, Jonathan E. Shaw, Frank Caruso, Mark E. Cooper, Christoph E. Hagemeyer, Francesca Cavalieri
Publikováno v:
Advanced Materials. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::777d58a5bc1fb4c1d5c66e0a7fa1c4d0
https://doi.org/10.1002/adma.202370146
https://doi.org/10.1002/adma.202370146
Glucose-responsive insulin-delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::a439ffea512043763bbe6f828faf4158
https://zenodo.org/record/7742843
https://zenodo.org/record/7742843
Autor:
John A. Karas, Labell J. M. Wong, Olivia K. A. Paulin, Amna C. Mazeh, Maytham H. Hussein, Jian Li, Tony Velkov
Publikováno v:
Antibiotics, Vol 9, Iss 7, p 406 (2020)
A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent need to discover new classes of potent antimicrobial agents with novel modes of action. Cann
Externí odkaz:
https://doaj.org/article/793672845a5c44dc8cae527ff2a49a9a
Autor:
Patrick F. James, Con Dogovski, Renwick C.J. Dobson, Michael F. Bailey, Kenneth N. Goldie, John A. Karas, Denis B. Scanlon, Richard A.J. O’Hair, Matthew A. Perugini
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 7, Pp 1384-1394 (2009)
Human apolipoprotein C-I (apoC-I) is an exchangeable apolipoprotein that binds to lipoprotein particles in vivo. In this study, we employed a LC-MS/MS assay to demonstrate that residues 38–51 of apoC-I are significantly protected from proteolysis i
Externí odkaz:
https://doaj.org/article/89e66b82093245dc8c5ecf64eee803c2
Autor:
Denham Hopper, Zihan Shen, Richard A. Hughes, Haoyue Zhang, Jordan Sfyris Qoon, John A. Karas, Qingqing Lin, Susan E. Northfield
Publikováno v:
ACS Omega, Vol 5, Iss 4, Pp 1840-1850 (2020)
ACS Omega
ACS Omega
The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of bio-orthogonal reactions that enable access to peptides of greater structural complexity. One approach utilizes 1,3-dic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103893f6b6328a77b2ccedc2658cca9c
https://doi.org/10.1021/acsomega.9b03152
https://doi.org/10.1021/acsomega.9b03152
Publikováno v:
Chemical Communications. 56:2897-2900
[Tm(DPA)3]3- was used to generate multiple, paramagnetic nuclear Overhauser effect NMR spectra of cationic peptides when weakly bound to a lipopolysaccharide micelle. Increased spectral resolution combined with a marked increase in the number of dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f7ef271eedfe28544be70de075d779
https://doi.org/10.1039/c9cc09207b
https://doi.org/10.1039/c9cc09207b