Výsledky vyhledávání - "John A, Hickman"

Akademický článek

Exploring Health-Related Quality of Life (HRQOL) among patients with HIV-associated TB in Khayelitsha, South Africa.

Autor: John-Henry Hickman, Alison Swartz, Namhla Sicwebu, Cari Stek, Nobom Masimini, Christiana Nöstlinger

Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0275554 (2024)

BackgroundHealth-related quality of life (HRQOL) is an important and frequently used patient-reported outcome in health research. However, little qualitative research exists in this field in South Africa. This study was set in Khayelitsha, one of the

Externí odkaz: https://doaj.org/article/361cb65880db4249b290c4f514171e05

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Predictive validity in drug discovery: what it is, why it matters and how to improve it

Autor: Jack W. Scannell, James Bosley, John A. Hickman, Gerard R. Dawson, Hubert Truebel, Guilherme S. Ferreira, Duncan Richards, J. Mark Treherne

Publikováno v: Nature Reviews Drug Discovery. 21:915-931

Successful drug discovery is like finding oases of safety and efficacy in chemical and biological deserts. Screens in disease models, and other decision tools used in drug research and development (R&D), point towards oases when they score therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215d03ac920c1d2ff8a18551f3f01f94
https://doi.org/10.1038/s41573-022-00552-x

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Supplementary Table S1 from S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

Pharmacokinetic parameters of S49076 administered orally to female balb/c nu/nu mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d85780489a7d5f2f98bfaf00e0d717
https://doi.org/10.1158/1535-7163.22500580.v1

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Data from S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies, notably in instances of primary or acquired resistance to existing or emerging anticancer t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430099b575997bc84c21ebae598114d2
https://doi.org/10.1158/1535-7163.c.6536506.v1

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Supplementary Figure S1 from S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

Western blot detection of total and phosphorylated MET, AXL, FGFR1/2/3 and phosphorylated FRS2 in cell lines and tumor xenografts used in the study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123135a315fe10245d8747481cf1d27a
https://doi.org/10.1158/1535-7163.22500589

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Supplementary Figure Legends from S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2531d2864ca4243b46130be353d490da
https://doi.org/10.1158/1535-7163.22500592.v1

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System Innovation for the Cancer Moonshot

Autor: Fred Steward, Jack Scannell, John Angus Hickman

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef4f3132814fd4b229ce8b737004d25
https://doi.org/10.2139/ssrn.4407120

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Natural Seismicity in and around the Rome Trough, Eastern Kentucky, from a Temporary Seismic Network

Autor: Zhenming Wang, Edward W. Woolery, N. Seth Carpenter, Steven L. Roche, Andrew S. Holcomb, John B. Hickman

Publikováno v: Seismological Research Letters. 91:1831-1845

The Rome trough is a northeast-trending graben system extending from eastern Kentucky northeastward across West Virginia and Pennsylvania into southern New York. The oil and gas potential of a formation deep in the trough, the Rogersville shale, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0717d26d1cd6e650ba375ba16d8e3ab
https://doi.org/10.1785/0220190015

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The Costs and Causes of Oncology Drug Attrition: The Insulin Growth Factor 1 Receptor

Autor: John Angus Hickman, Valerie Jentzsch, Leeza Osipenko, Jack Scannell

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7146b54d83d09f2026ec1a63c285d24a
https://doi.org/10.2139/ssrn.4277512

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The European Union and personalised cancer medicine

Autor: Ian F. Tannock, Lydie Meheus, Lisa Hutchinson, John A. Hickman

Publikováno v: European journal of cancer (Oxford, England : 1990). 150

Two recent policy documents by the European Union, ‘Europe's Beating Cancer Plan’ and its accompanying ‘Conquering Cancer: Mission Possible’ (CCMP), articulate broad policies aimed at reducing cancer mortality across Europe, for example, by p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644aab18f658542bfa2e59dff1be0280
https://pubmed.ncbi.nlm.nih.gov/33892410

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