Zobrazeno 1 - 10
of 129
pro vyhledávání: '"John Moffat"'
Publikováno v:
Journal of Materials Research and Technology, Vol 33, Iss , Pp 3058-3067 (2024)
High-performance supercars using Li-ion batteries necessitate thicker aluminium busbars with thin steel joints. However, joining these materials often leads to overheating resulting in brittle intermetallic compounds (IMCs), reduced weld quality, and
Externí odkaz:
https://doaj.org/article/13f8381e815f4e69940effe7f3198914
Publikováno v:
European Physical Journal C: Particles and Fields, Vol 84, Iss 3, Pp 1-9 (2024)
Abstract The emergence of supermassive black holes (SMBHs) in the early universe remains a topic of profound interest and debate. In this paper, we investigate the formation and growth of the first SMBHs within the framework of Modified Gravity (MOG)
Externí odkaz:
https://doaj.org/article/98d2da5ea47e426cb4ccdfb2da4adf73
Publikováno v:
Physics Letters B, Vol 779, Iss , Pp 492-497 (2018)
The Quasinormal modes (QNMs) for gravitational and electromagnetic perturbations are calculated in a Scalar–Tensor–Vector (Modified Gravity) spacetime, which was initially proposed to obtain correct dynamics of galaxies and galaxy clusters withou
Externí odkaz:
https://doaj.org/article/fa5e78aa423f47f68e93a664f2dda961
Autor:
Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-17 (2017)
Systems pharmacology:Predicting efficacy of novel anti-cancer drugs in colorectal cancer While cancer drug development relies on experimental tumor models for testing, results observed in these systems often fail to translate clinically. Kirouac et a
Externí odkaz:
https://doaj.org/article/6bfc02d0615b4d33ac88a7be2e3e419b
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07be02e8e9258d59fd0d5344faa763ab
https://doi.org/10.1158/1535-7163.c.6535320.v1
https://doi.org/10.1158/1535-7163.c.6535320.v1
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
PDF file - 451K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923262ef522e46408ad2b4fe9b478f6
https://doi.org/10.1158/1535-7163.22496553
https://doi.org/10.1158/1535-7163.22496553
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Supplementary Table S1: X-ray crystallography data processing and structure refinement statistics Supplementary Table S2: BRAF and RAS mutational status of cell lines used in the study Supplementary Table: S3: Cellular IC50 (nM) of parental and ERKi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a818d88cbb2792b0dc8376b635414b
https://doi.org/10.1158/1078-0432.22475625
https://doi.org/10.1158/1078-0432.22475625
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Purpose: MAPK pathway inhibitors targeting BRAF and MEK have shown clinical efficacy in patients with RAF- and/or RAS-mutated tumors. However, acquired resistance to these agents has been an impediment to improved long-term survival in the clinic. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e9fdf05a747ff859670a43c8cc3d77
https://doi.org/10.1158/1078-0432.c.6529128
https://doi.org/10.1158/1078-0432.c.6529128
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395ca6436d6c1d18c409c6cbe9805ecd
https://doi.org/10.1158/1078-0432.22475637.v1
https://doi.org/10.1158/1078-0432.22475637.v1
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Fig. S1. ERK inhibitors and their effect on MAPK mutant cell lines. A. Structure of ERK inhibitors used in this study. B. Dose response curve of ERK inhibitors on the viability of A375, IPC298, SKMEL30, HCT116, MIA PaCa2 and Panc1 cells. Fig. S2. Wes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c639fc3b3c95d5a8d0b4b6b91292ec4
https://doi.org/10.1158/1078-0432.22475634
https://doi.org/10.1158/1078-0432.22475634