Zobrazeno 1 - 10
of 179
pro vyhledávání: '"John Garthwaite"'
Autor:
Scott A. Waldman, Johannes-Peter Stasch, Harald H.H.W. Schmidt, Michael Russwurm, Lincoln R. Potter, Michaela Kuhn, Doris Koesling, Adrian J. Hobbs, John Garthwaite, Andreas Friebe, John C. Burnett, Jr., Peter Brouckaert, Annie Beuve
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0460dae32cdc55f3a688fbeb8b3a11
https://doi.org/10.2218/gtopdb/f1022/2023.1
https://doi.org/10.2218/gtopdb/f1022/2023.1
Autor:
Konstantina Chachlaki, Andrea Messina, Virginia Delli, Valerie Leysen, Csilla Maurnyi, Chieko Huber, Gaëtan Ternier, Katalin Skrapits, Georgios Papadakis, Sonal Shruti, Maria Kapanidou, Xu Cheng, James Acierno, Jesse Rademaker, Sowmyalakshmi Rasika, Richard Quinton, Marek Niedziela, Dagmar L’Allemand, Duarte Pignatelli, Mirjam Dirlewander, Mariarosaria Lang-Muritano, Patrick Kempf, Sophie Catteau-Jonard, Nicolas J. Niederländer, Philippe Ciofi, Manuel Tena-Sempere, John Garthwaite, Laurent Storme, Paul Avan, Erik Hrabovszky, Alan Carleton, Federico Santoni, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b9ba2a2f53ed6983bfc3208da7475d
https://www.hal.inserm.fr/inserm-03841246
https://www.hal.inserm.fr/inserm-03841246
Autor:
Lincoln R. Potter, Johannes-Peter Stasch, Michael Russwurm, Peter Brouckaert, John C. Burnett, John Garthwaite, Andreas Friebe, Scott A. Waldman, Annie Beuve, Adrian J. Hobbs, Michaela Kuhn, Doris Koesling, Harald H.H.W. Schmidt
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 3:1-4
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32993caa2f776e95f6e4db4572b0c4a9
https://doi.org/10.2218/gtopdb/f1022/2021.3
https://doi.org/10.2218/gtopdb/f1022/2021.3
Autor:
Tom P. Monie, Simon D. Harding, Csaba Szabó, Lincoln R. Potter, Stephen P.H. Alexander, Peter Brouckaert, Jamie A. Davies, Harald H.H.W. Schmidt, Elena Faccenda, Christopher Southan, Eamonn Kelly, John Garthwaite, Scott A. Waldman, Jane F. Armstrong, Andreas Papapetropoulos, Michaela Kuhn, Adam J. Pawson, John A. Peters, David J. MacEwan, John C. Burnett, Clare E. Bryant, Annie Beuve, Richard W. Farndale, Andreas Friebe, Adrian J. Hobbs, Emma L. Veale, Gavin E. Jarvis, Alistair Mathie, Doriano Fabbro
Publikováno v:
British Journal of Pharmacology, 178, S264-S312. Wiley
BRITISH JOURNAL OF PHARMACOLOGY
BRITISH JOURNAL OF PHARMACOLOGY
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04b5015c3aa5922d916592b1c9be493
https://pubmed.ncbi.nlm.nih.gov/34529829
https://pubmed.ncbi.nlm.nih.gov/34529829
Autor:
Anastasia Karchevskaya, Tomas C. Bellamy, A. W. Edith Chan, David L. Selwood, Robert G. Keynes, Dieter Riddall, Charmaine Griffiths, John Garthwaite
Publikováno v:
Chemical Biology & Drug Design. 94:1680-1693
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14da4a9f25f9fa1942b18564f7d156d
https://doi.org/10.1111/cbdd.13572
https://doi.org/10.1111/cbdd.13572
Autor:
Konstantina Chachlaki, Andrea Messina, Virginia Delli, Valerie Leysen, Csilla Maurnyi, Katalin Scrapits, Philippe Ciofi, Nicolas J. Niederlander, Manuel Tena-Sempere, Laurent Storme, Paul Avan, Erik Hrabovszky, John Garthwaite, Federico Santoni, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot
Publikováno v:
Free Radical Biology and Medicine. 189:14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3751f2c832e849dddebcf58bf563ca2
https://doi.org/10.1016/j.freeradbiomed.2022.06.072
https://doi.org/10.1016/j.freeradbiomed.2022.06.072
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57292 (2013)
In the hippocampus, as in many other CNS areas, nitric oxide (NO) participates in synaptic plasticity, manifested as changes in pre- and/or postsynaptic function. While it is known that these changes are brought about by cGMP following activation of
Externí odkaz:
https://doaj.org/article/6b635e02090c4624b2c383e94addf253
Autor:
Michaela Kuhn, John Garthwaite, Annie Beuve, Scott A. Waldman, Peter Brouckaert, Michael Russwurm, Doris Koesling, John C. Burnett, Lincoln R. Potter, Harald H.H.W. Schmidt, Adrian J. Hobbs, Andreas Friebe, Johannes-Peter Stasch
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2020
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c770ccb0eba1951193ee74d7999f09f
https://doi.org/10.2218/gtopdb/f1022/2020.3
https://doi.org/10.2218/gtopdb/f1022/2020.3
Autor:
John Garthwaite
Publikováno v:
British Journal of Pharmacology. 176:197-211
NO operates throughout the brain as an intercellular messenger, initiating its varied physiological effects by activating specialized GC-coupled receptors, resulting in the formation of cGMP. In line with the widespread expression of this pathway, NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376cae7b6319f60ecfa01c1c6f4b6cd3
https://doi.org/10.1111/bph.14532
https://doi.org/10.1111/bph.14532
Autor:
Lincoln R. Potter, Scott A. Waldman, Peter Brouckaert, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Michaela Kuhn, John C. Burnett, Adrian J. Hobbs, John Garthwaite, Doris Koesling, Andreas Friebe, Michael Russwurm, Annie Beuve
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
The mammalian genome encodes transmembrane and soluble receptor guanylyl cyclases, both of which have enzyme activities which convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::445c0b56a75b728471d0505991f0c66d
https://doi.org/10.2218/gtopdb/f1022/2019.4
https://doi.org/10.2218/gtopdb/f1022/2019.4