Výsledky vyhledávání - "John G. Van Alsten"

Continuous flow aminolysis under high temperature and pressure

Autor: Cheryl Myers Hayward, Ruggeri Sally G, David C. Limburg, John G. Van Alsten, Ruizhi Li, Steve M. Guinness, John C. Lucas, Scott Bader, Steve Hoagland, Bryan Li, Raggon Jeffrey W, J. Christopher McWilliams

Publikováno v: Journal of Flow Chemistry. 10:145-156

Under continuous processing conditions, C-N bond formation via SN2 and SNAr substitutions by amines can be an effective preparative method, especially when volatile amines are used under high pressure and temperature. We have demonstrated SN2 substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b47c098a0c88d457bfddad5da51835b6
https://doi.org/10.1007/s41981-019-00049-6

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Development of the Commercial Route for the Manufacture of a 5-Lipoxygenase Inhibitor PF-04191834

Autor: Gerald A. Weisenburger, Brian Patrick Chekal, Janice E. Sieser, Brian C. Vanderplas, David B. Damon, Michael St. Pierre, John G. Van Alsten, Carlos Mojica, Kyle R. Leeman, Danny Lafrance, Carrie Wager, Shu Yu, Rajappa Vaidyanathan, Gregory J. Withbroe, Karen Sutherland, Andrew S. Palm

Publikováno v: Organic Process Research & Development. 19:1944-1953

A de novo three-step-one-pot process for the formation of PF-04191834 was developed. This methodology employed inexpensive, odorless, and readily available commodity chemical iso-octyl-3-mercaptopropionate as a sulfur source, which could be a general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b86ed2168e64162a477212d79c402d9c
https://doi.org/10.1021/op500412a

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Chemical Development of an α2δ Ligand, (3S,5R)-3-(Aminomethyl)-5-methyloctanoic Acid

Autor: Gino Gabellone, Lloyd Charles Franklin, Thomas Norman Nanninga, Lisa M. Reeder, Niamh J. Panesar, Kyle Kissick, Catherine Dunne, Stuart Field, Martinez Carlos, John W. Wong, George Smith, James Saenz, Margaret Claire Evans, Lorraine Murtagh, John G. Van Alsten

Publikováno v: Organic Process Research & Development. 15:1315-1327

Three synthetic approaches, suitable for the large scale manufacture of the α2δ-ligand, (3S,5R)-3-(aminomethyl)-5-methyloctanoic acid 3, have been evaluated. The selected seven step manufacturing process has then been optimized and used to deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f4690618c9c38799606815eec00d7c
https://doi.org/10.1021/op2001832

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Hydrogenation of a Pharmaceutical Intermediate by a Continuous Stirred Tank Reactor System

Autor: Matthew L. Jorgensen, David J. am Ende, John G. Van Alsten

Publikováno v: Organic Process Research & Development. 13:629-633

A proof of concept study on the continuous hydrogenation of a pharmaceutical intermediate is presented. A slurry feed of CP-548495, a dintro intermediate in a smoking cessation drug, was reduced in a two-reactor continuous stirred tank train to the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4be4de8aa52a9884e66d6f59536e593c
https://doi.org/10.1021/op800170r

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Continuous Reaction/Crystallization Process for Production of a Hazardous Intermediate

Autor: Donald J. Knoechel, Corey L. Stanchina, John G. Van Alsten, Lisa M. Reeder

Publikováno v: Organic Process Research & Development. 12:989-994

Perchloric acid appears unique in its ability to catalyze stereoselective trans-acetalizations of steroids. However, the requisite recipes result in an intermediate phase enriched in perchlorate and organic material with the potential for catastrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8dabd89227182cf30b7b3513d3bee48
https://doi.org/10.1021/op800128g

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Effect of entrainers and of solute size and polarity in supercritical fluid solutions

Autor: Charles A. Eckert, John G. Van Alsten

Publikováno v: Journal of Chemical & Engineering Data. 38:605-610

Although supercritical extraction has been widely publicized as a novel separation technique of great versatility, it now appears that its applications will be in a number of specialized situations, each characterized by a rather specific set of requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac86e425fd60cd00b7341742064fadb3
https://doi.org/10.1021/je00012a034

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