Zobrazeno 1 - 10
of 195
pro vyhledávání: '"John Forsayeth"'
Autor:
Kousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus, Michael V. Campagna, Waldy San Sebastian, Jerusha Naidoo, Haifeng Chen, John Forsayeth, Ernesto A. Salegio, Granger G.C. Hwa, Krystof S. Bankiewicz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 47-54 (2019)
Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via
Externí odkaz:
https://doaj.org/article/5a819b72674d4e9490c437bdab03d8bd
Autor:
John Forsayeth, Piotr Hadaczek
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Here we advance the hypothesis that Parkinson's disease (PD) is fundamentally a failure of trophic support for specific classes of neurons, primarily catecholaminergic. Evidence from our laboratory provides a framework into which a broad array of fin
Externí odkaz:
https://doaj.org/article/328da69787ce4689b5a3f097fda82f93
Autor:
Agnieszka Ciesielska, Lluis Samaranch, Waldy San Sebastian, Dennis W Dickson, Samuel Goldman, John Forsayeth, Krystof S Bankiewicz
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0169965 (2017)
In Parkinson's disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Previous studies in PD animal models demonstrated that lesion of dopaminergic neurons is assoc
Externí odkaz:
https://doaj.org/article/ea75beb4441043c3b6b8c31c4b570fb2
Autor:
Piotr Hadaczek, Lisa Stanek, Agnieszka Ciesielska, Vivek Sudhakar, Lluis Samaranch, Philip Pivirotto, John Bringas, Catherine O'Riordan, Bryan Mastis, Waldy San Sebastian, John Forsayeth, Seng H Cheng, Krystof S Bankiewicz, Lamya S Shihabuddin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Huntington's disease (HD) is caused by a toxic gain-of-function associated with the expression of the mutant huntingtin (htt) protein. Therefore, the use of RNA interference to inhibit Htt expression could represent a disease-modifying therapy. The p
Externí odkaz:
https://doaj.org/article/43ac05468e3949adbb6afe92f17bbcd0
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 2, Pp 228-235 (2012)
Delivery of neurotrophic factors to treat neurodegenerative diseases has not been efficacious in clinical trials despite their known potency for promoting neuronal growth and survival. Direct gene delivery to the brain offers an approach for establis
Externí odkaz:
https://doaj.org/article/54c501d0d78f45dfa195aaa5c7f9e614
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122708 (2015)
Progressively blunted response to L-DOPA in Parkinson's disease (PD) is a critical factor that complicates long-term pharmacotherapy in view of the central importance of this drug in management of the PD-related motor disturbance. This phenomenon is
Externí odkaz:
https://doaj.org/article/5e5f5493b2af4fd7981f9d528d8575d0
Autor:
Lluis Samaranch, John Forsayeth, Waldy San Sebastian, Krystof S. Bankiewicz, Ernesto A. Salegio, Philip C. Allen, Piotr Hadaczek, Haifeng Chen, Michael V. Campagna, Jerusha Naidoo, Granger G.C. Hwa, Kousaku Ohno, John Bringas, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 47-54 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e868c604fb9c50fcf1cdebefedd028e
http://www.sciencedirect.com/science/article/pii/S2329050118301232
http://www.sciencedirect.com/science/article/pii/S2329050118301232
Autor:
Waldy San Sebastian, Adrian P Kells, John Bringas, Lluis Samaranch, Piotr Hadaczek, Agnieszka Ciesielska, Michael J Macayan, Phillip J Pivirotto, John Forsayeth, Sheryl Osborne, J Fraser Wright, Foad Green, Gregory Heller, Krystof S Bankiewicz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the DDC gene that leads to an inability to synthesize catecholamines and serotonin. As a result, patients suffer comprom
Externí odkaz:
https://doaj.org/article/6808879212064f8090e19ab0d9b2d62a
Autor:
Suzanne M. Green-Fulgham, Megan Fry, Robert Landry, Collins Stephen, Raymond A. Chavez, David K. Glover, John Forsayeth, Jonathan D. Coulson, Jayson M. Rieger, Linda R. Watkins
Publikováno v:
Brain, behavior, and immunity. 90
Osteoarthritis results in chronic pain and loss of function. Proinflammatory cytokines create both osteoarthritis pathology and pain. Current treatments are poorly effective, have significant side effects, and have not targeted the cytokines central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b3a0c0b37be82219d124a51424820d
https://pubmed.ncbi.nlm.nih.gov/32800926
https://pubmed.ncbi.nlm.nih.gov/32800926
Autor:
Kousaku Ohno, John Forsayeth, Amir Mahmoodi, Waldy San Sebastian, Amin Mahmoodi, Krystof S. Bankiewicz, Lamya S. Shihabuddin, Savanah Trewman, Jerusha Naidoo, Catherine R. O'Riordan, Piotr Hadaczek, Lisa M. Stanek, John Bringas, Jennifer Sullivan, Christopher Snieckus, Lluis Samaranch
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 10
The present study was designed to characterize transduction of non-human primate brain and spinal cord with a modified adeno-associated virus serotype 2, incapable of binding to theheparan sulfate proteoglycan receptor, referred to as AAV2-HBKO. AAV2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43439e3c94e50be5bc9e21e6cd4f7a73
https://doi.org/10.1016/j.ymthe.2018.07.008
https://doi.org/10.1016/j.ymthe.2018.07.008