Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John D. Knight"'
Autor:
Chirine Soubra-Ghaoui, John D. Knight, Md. Nasir Uddin, Judy I. Wu, Ettore J. Rastelli, Chia-Hua Wu, Thomas A. Albright, Don M. Coltart
Publikováno v:
Chemistry
he mechanistic details of the aldol addition of N-amino cyclic carbamate (ACC) hydrazones is provided herein from both an experimental and computational perspective. When the transformation is carried out at room temperature the anti-aldol product is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942298e08db7cc3eb4ab96bb031bc60
https://pubmed.ncbi.nlm.nih.gov/31650641
https://pubmed.ncbi.nlm.nih.gov/31650641
Publikováno v:
Organic Letters
A dianionic Ireland-Claisen rearrangement of chiral, nonracemic α-methyl-β-hydroxy allylic esters has been developed that proceeds with high diastereoselectivity and provides products containing three contiguous stereogenic carbons, including a qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b53ccc65105e8d3bcfea0dc06dc23c
https://doi.org/10.1021/ol5008422
https://doi.org/10.1021/ol5008422
Publikováno v:
Organic Letters. 13:3118-3121
Mefloquine hydrochloride is an important antimalarial drug. It is currently manufactured and administered in racemic form; however there are indications regarding the biological activity of the two enantiomers that suggest the superiority of the (+)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d7dbdaf6d9856ecc2474dd9be24d8
https://doi.org/10.1021/ol2010193
https://doi.org/10.1021/ol2010193
Publikováno v:
Journal of Chemical Crystallography. 40:536-540
A new type of substituted benzothiopyranone, 3-phenyl-2-(2-phenylhydrazino)-4H-1-benzothiopyran-4-one, has been prepared by the condensation-acid cyclization of polylithiated phenylacetic acid phenylhydrazide with lithiated methyl thiosalicylate. Abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a3f8baa9f6160c54a613030b570ae4b
https://doi.org/10.1007/s10870-010-9692-z
https://doi.org/10.1007/s10870-010-9692-z
Autor:
Kevin J. Bigham, Jordan B. Brown, William T. Pennington, Anna C. Dawsey, Clyde R. Metz, John D. Knight, Don VanDerveer, Charles F. Beam
Publikováno v:
Journal of Chemical Crystallography. 40:296-301
Dilithiated C(α), N-carbomethoxyhydrazones were condensed with lithiated methyl 2-(aminosulfonyl)benzoate to afford intermediates that were isolated and not characterized but cyclized with acetic anhydride, which also resulted in N-acetylation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c564abfd6c325a8e53d9fc149c03a3a
https://doi.org/10.1007/s10870-009-9649-2
https://doi.org/10.1007/s10870-009-9649-2
Autor:
Don VanDerveer, Anna C. Dawsey, Clyde R. Metz, Andrew J. Puciaty, Chandra Potter, Ellyn A. Smith, Amanda M. Acevedo-Jake, Charles F. Beam, William T. Pennington, Zachary C. Kennedy, John D. Knight
Publikováno v:
Journal of Heterocyclic Chemistry. 46:231-236
A variety of substituted spiro(benzoisothiazole-pyrazoles) have been prepared by the condensation of dilithiated C(α),N-carboalkoxyhydrazones with lithiated methyl 2-(aminosulfonyl)benzoate followed by the cyclization of intermediates with acetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed7e68c926131458778a098f6500f44
https://doi.org/10.1002/jhet.50
https://doi.org/10.1002/jhet.50
Publikováno v:
Synthetic Communications. 38:4150-4159
Select C(α),N-phenylhydrazones were dilithiated with excess lithium diisopropylamide to their dianion-type intermediates followed by condensation with methyl hydrogen phthalate. The resulting C-acylated hydrazones were not isolated but acid cyclized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b745012c726db9cdbbe43556d87e4a
https://doi.org/10.1080/00397910802323049
https://doi.org/10.1080/00397910802323049
Publikováno v:
Synthetic Communications. 38:2465-2482
Lithium hexamethyldisilazide (LiHMDS) was used to condense substituted benzoate esters with acetone to afford symmetrical 1,5-diaryl-1,3,5-pentanetriones that were isolated, characterized (including a representative X-ray crystallographic analysis),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6f98281758e40188808e3496df6cc4
https://doi.org/10.1080/00397910802138488
https://doi.org/10.1080/00397910802138488
Autor:
J. Matthew Rhett, John D. Knight, Matthew J. Walters, Maria D. Malatanos, Charles F. Beam, S. Patrick Dunn, Emily Choi
Publikováno v:
Synthetic Communications. 38:713-722
Dilithiated 2‐tetralone oxime, prepared in excess lithium diisopropylamide, was condensed with aromatic esters, such as methyl 4‐methoxybenzoate, followed by cyclization of the C‐acylated intermediate with aqueous acid to give dihydronaphthisox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c08d252798f380f799daf0fd3e12864
https://doi.org/10.1080/00397910701820228
https://doi.org/10.1080/00397910701820228
Publikováno v:
Journal of Heterocyclic Chemistry. 45:189-194
Select C(α), N-carbo-tert-butoxyhydrazones were dilithiated with excess lithium diisopropylamide followed by condensation with methyl 2-(aminosulfonyl)benzoate, acid cyclization, hydrolysis, and decarboxylation to afford new 2-(1H-pyrazol-5-yl)benze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f01f561b9cad0396b68c472d29d8bf7
https://doi.org/10.1002/jhet.5570450122
https://doi.org/10.1002/jhet.5570450122