Zobrazeno 1 - 10
of 102
pro vyhledávání: '"John Bringas"'
Autor:
Vasco Meneghini, Annalisa Lattanzi, Luigi Tiradani, Gabriele Bravo, Francesco Morena, Francesca Sanvito, Andrea Calabria, John Bringas, Jeanne M Fisher‐Perkins, Jason P Dufour, Kate C Baker, Claudio Doglioni, Eugenio Montini, Bruce A Bunnell, Krystof Bankiewicz, Sabata Martino, Luigi Naldini, Angela Gritti
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 489-510 (2016)
Abstract Metachromatic leukodystrophy (MLD) and globoid cell leukodystrophy (GLD or Krabbe disease) are severe neurodegenerative lysosomal storage diseases (LSD) caused by arylsulfatase A (ARSA) and galactosylceramidase (GALC) deficiency, respectivel
Externí odkaz:
https://doaj.org/article/df4a76df4d1e46e5afca6e405d504c4a
Autor:
Piotr Hadaczek, Lisa Stanek, Agnieszka Ciesielska, Vivek Sudhakar, Lluis Samaranch, Philip Pivirotto, John Bringas, Catherine O'Riordan, Bryan Mastis, Waldy San Sebastian, John Forsayeth, Seng H Cheng, Krystof S Bankiewicz, Lamya S Shihabuddin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Huntington's disease (HD) is caused by a toxic gain-of-function associated with the expression of the mutant huntingtin (htt) protein. Therefore, the use of RNA interference to inhibit Htt expression could represent a disease-modifying therapy. The p
Externí odkaz:
https://doaj.org/article/43ac05468e3949adbb6afe92f17bbcd0
Publikováno v:
Journal of Neurosurgery. 133:611-613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a17d41bf9ce2ee105ff8ca407937732
https://doi.org/10.3171/2019.4.jns19614
https://doi.org/10.3171/2019.4.jns19614
Autor:
Lluis Samaranch, John Forsayeth, Waldy San Sebastian, Krystof S. Bankiewicz, Ernesto A. Salegio, Philip C. Allen, Piotr Hadaczek, Haifeng Chen, Michael V. Campagna, Jerusha Naidoo, Granger G.C. Hwa, Kousaku Ohno, John Bringas, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 47-54 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e868c604fb9c50fcf1cdebefedd028e
http://www.sciencedirect.com/science/article/pii/S2329050118301232
http://www.sciencedirect.com/science/article/pii/S2329050118301232
Autor:
Waldy San Sebastian, Adrian P Kells, John Bringas, Lluis Samaranch, Piotr Hadaczek, Agnieszka Ciesielska, Michael J Macayan, Phillip J Pivirotto, John Forsayeth, Sheryl Osborne, J Fraser Wright, Foad Green, Gregory Heller, Krystof S Bankiewicz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the DDC gene that leads to an inability to synthesize catecholamines and serotonin. As a result, patients suffer comprom
Externí odkaz:
https://doaj.org/article/6808879212064f8090e19ab0d9b2d62a
Autor:
Kousaku Ohno, John Forsayeth, Amir Mahmoodi, Waldy San Sebastian, Amin Mahmoodi, Krystof S. Bankiewicz, Lamya S. Shihabuddin, Savanah Trewman, Jerusha Naidoo, Catherine R. O'Riordan, Piotr Hadaczek, Lisa M. Stanek, John Bringas, Jennifer Sullivan, Christopher Snieckus, Lluis Samaranch
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 10
The present study was designed to characterize transduction of non-human primate brain and spinal cord with a modified adeno-associated virus serotype 2, incapable of binding to theheparan sulfate proteoglycan receptor, referred to as AAV2-HBKO. AAV2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43439e3c94e50be5bc9e21e6cd4f7a73
https://doi.org/10.1016/j.ymthe.2018.07.008
https://doi.org/10.1016/j.ymthe.2018.07.008
Autor:
John Bringas, Viktor Kharazia, Adrian P. Kells, Krystof S. Bankiewicz, Nan Tian, Ji-Wei He, Azadeh Yazdan-Shahmorad, Lluis Samaranch, Philip N. Sabes
Publikováno v:
Journal of Neuroscience Methods. 293:347-358
Background In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus (AAV) in the thalamus by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf471353da5099cd70ba9aa2550950e
https://doi.org/10.1016/j.jneumeth.2017.10.009
https://doi.org/10.1016/j.jneumeth.2017.10.009
Autor:
John Forsayeth, Piotr Hadaczek, Vivek Sudhakar, Josefina Casas, Jesús Avila, Beatriz Soto-Huelin, Seng H. Cheng, Maria Dolores Ledesma, Haifeng Chen, Krystof S. Bankiewicz, Xingxuan He, Jerónimo Jurado-Arjona, John Bringas, Lluis Samaranch, Edward H. Schuchman, Azucena Pérez-Cañamás
Publikováno v:
Sci Transl Med
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science translational medicine, vol 11, iss 506
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science translational medicine, vol 11, iss 506
Niemann-Pick disease type A (NPD-A) is a lysosomal storage disorder characterized by neurodegeneration and early death. It is caused by loss-of-function mutations in the gene encoding for acid sphingomyelinase (ASM), which hydrolyzes sphingomyelin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74246c752976933fc101148f429e64d2
http://hdl.handle.net/10261/191697
http://hdl.handle.net/10261/191697
Autor:
Massimo S. Fiandaca, Vivek Sudhakar, Russell R. Lonser, Jerusha Naidoo, John Bringas, Krystof S. Bankiewicz, Lluis Samaranch
Publikováno v:
Journal of neurosurgery.
OBJECTIVETo develop and assess a convective delivery technique that enhances the effectiveness of drug delivery to nonspherical brain nuclei, the authors developed an occipital “infuse-as-you-go” approach to the putamen and compared it to the cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb682624aeee746632691c2707fad72b
https://pubmed.ncbi.nlm.nih.gov/31299656
https://pubmed.ncbi.nlm.nih.gov/31299656
Autor:
Krys S. Bankiewicz M.D., Ph.D., John Bringas, Phillip Pivirotto, Ethan Kutzscher, Dea Nagy, Marina E. Emborg
Publikováno v:
Cell Transplantation, Vol 9 (2000)
Intracerebral grafting combined with gene transfer may provide a powerful technique for local delivery of therapeutic agents into the CNS. The present study was undertaken to: (i) develop a reliable and reproducible automated cell implantation system
Externí odkaz:
https://doaj.org/article/be12c79abbcd4f39b3267dc654b3efcb