Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Autor: Yongmei Liu, Tuomas O. Kilpeläinen, Kenneth Rice, Ching-Ti Liu, Jin-Fang Chai, Donna K. Arnett, Dhananjay Vaidya, Nicholette D. Palmer, Lili Milani, Yuri Milaneschi, Leo-Pekka Lyytikäinen, Colleen M. Sitlani, Richard S. Cooper, Gudny Eiriksdottir, Daniel Levy, Jerome I. Rotter, Lihua Wang, Sven Bergmann, Yih Chung Tham, Thomas Meitinger, Lynne E. Wagenknecht, Virginia Fisher, Babatunde L. Salako, Vilmundur Gudnason, Bamidele O. Tayo, Caizheng Yu, Barry I. Freedman, Muhammad Riaz, Kaare Christensen, Ulrich Broeckel, W. James Gauderman, Massimiliano Cocca, Eric Boerwinkle, Meian He, Rob M. van Dam, M. Arfan Ikram, Lisa de las Fuentes, Jiang He, Aldi T. Kraja, Nancy L. Pedersen, Albert V. Smith, Woon-Puay Koh, Bernardo L. Horta, He Gao, Traci M. Bartz, Mike A. Nalls, Federica Laguzzi, Raymond Noordam, Paul M. Ridker, Tien Yin Wong, Patricia B. Munroe, Paul S. de Vries, Adolfo Correa, Maris Alver, Dan E. Arking, Colin A. McKenzie, John M. Starr, Chi Charles Gu, Dongfeng Gu, Stefan Weiss, Patricia A. Peyser, Jessica D. Faul, Xu Chen, Jill M. Norris, Patrik K. E. Magnusson, Tamar Sofer, Ioanna Ntalla, Xiuqing Guo, Paul Elliott, Lawrence F. Bielak, Konstantin Strauch, Xueling Sim, Norihiro Kato, Evangelos Evangelou, Ilja M. Nolte, Steven C. Hunt, Mario Sims, Giorgia Girotto, Chuan Gao, Pamela J. Schreiner, Philippe Froguel, Archie Campbell, Xiao-Ou Shu, Claude Bouchard, Kurt Lohman, David R. Weir, José Eduardo Krieger, Yii-Der Ida Chen, Rainer Rauramaa, Walter Palmas, Cornelia M. van Duijn, James M. Shikany, Michael M. Province, Jennifer A. Smith, Wei Zheng, Xiaofeng Zhu, Jianjun Liu, Ozren Polasek, Alexandre C. Pereira, Diane M. Becker, Kari E. North, Salman M. Tajuddin, Deng Xuan, Leslie J. Raffel, Jie Yao, Astrid Petersmann, Ervin F. Fox, Mark J. Caulfield, Daniel I. Chasman, Jasmin Divers, Claudia P. Cabrera, Rico Rueedi, M. Yldau van der Ende, Carl D. Langefeld, Mika Kähönen, Terrence Forrester, Tangchun Wu, Harold Snieder, Caroline Hayward, Tamara B. Harris, Fang-Chi Hsu, Helen R. Warren, Brenda W.J.H. Penninx, Chiea Chuen Khor, Ruifang Li-Gao, Changwei Li, Sami Heikkinen, Jeffrey R. O'Connell, Christian Gieger, Michele K. Evans, Ching-Yu Cheng, Jingjing Liang, Stephen B. Kritchevsky, Gregory L. Burke, Donald W. Bowden, Alexander Teumer, Marcus Dörr, Alanna C. Morrison, Jian-Min Yuan, Annette Peters, Dennis O. Mook-Kanamori, Pedro Marques-Vidal, Pirjo Komulainen, Lisa R. Yanek, Melanie Waldenberger, Alisa K. Manning, Charles N. Rotimi, Chew-Kiat Heng, Tõnu Esko, Franco Giulianini, Miao Li Chee, Treva Rice, David J. Porteous, Yechiel Friedlander, Bing Yu, Myriam Fornage, Karin Leander, Dina Vojinovic, Sharon L.R. Kardia, Xiaoyin Li, Najaf Amin, Karen Schwander, Thomas T. Perls, Oscar Leonel Rueda-Ochoa, Erin B. Ware, Ya Xing Wang, Sandosh Padmanabhan, H. Janaka de Silva, André G. Uitterlinden, Rajkumar Dorajoo, Bruna Gigante, Jennifer A. Brody, Paolo Gasparini, Maryam Kavousi, Wanqing Wen, Stephen Sidney, Alan B. Zonderman, Michael R. Brown, Tuomo Rankinen, Timo A. Lakka, Yun Ju Sung, Alaitz Poveda, Bruce M. Psaty, Terho Lehtimäki, Tanika N. Kelly, Igor Rudan, Brigitte Kühnel, Christopher P. Nelson, John M. C. Connell, Mickaël Canouil, Niek Verweij, Thomas W. Winkler, Ian J. Deary, Marco Brumat, Yize Li, Fumihiko Takeuchi, Wei Zhao, Andres Metspalu, Marguerite R. Irvin, David C. Liewald, Pim van der Harst, Hugues Aschard, Candace M. Kammerer, Melissa A. Richard, Adesola Ogunniyi, Wen Bin Wei, Morris A. Swertz, Fernando Pires Hartwig, Dabeeru C. Rao, Reedik Mägi, Solomon K. Musani, Mathilde Boissel, Jonathan Marten, Nilesh J. Samani, Amy R. Bentley, Sarah E. Harris, Charumathi Sabanayagam, Mary F. Feitosa, Jost B. Jonas, Andrea R. V. R. Horimoto, Paul W. Franks, E. Shyong Tai

Publikováno v: Molecular Psychiatry, 26, 2111-2125. NATURE PUBLISHING GROUP
Molecular psychiatry
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-0719-3⟩
Molecular Psychiatry, 26(6), 2111-2125. Nature Publishing Group
Molecular Psychiatry, 2020, ⟨10.1038/s41380-020-0719-3⟩
de las Fuentes, L, Sung, Y J, Noordam, R, Winkler, T, Feitosa, M F, Schwander, K, Bentley, A R, Brown, M R, Guo, X, Manning, A, Chasman, D I, Aschard, H, Bartz, T M, Bielak, L F, Campbell, A, Cheng, C Y, Dorajoo, R, Hartwig, F P, Horimoto, A R V R, Li, C, Li-Gao, R, Liu, Y, Marten, J, Musani, S K, Ntalla, I, Rankinen, T, Richard, M, Sim, X, Smith, A V, Tajuddin, S M, Tayo, B O, Vojinovic, D, Warren, H R, Xuan, D, Alver, M, Boissel, M, Chai, J F, Chen, X, Christensen, K, Divers, J, Evangelou, E, Gao, C, Girotto, G, Harris, S E, He, M, Hsu, F C, Kühnel, B, Laguzzi, F, Li, X, Lyytikäinen, L P, Nolte, I M, Poveda, A, Rauramaa, R, Riaz, M, Rueedi, R, Shu, X O, Snieder, H, Sofer, T, Takeuchi, F, Verweij, N, Ware, E B, Weiss, S, Yanek, L R, Amin, N, Arking, D E, Arnett, D K, Bergmann, S, Boerwinkle, E, Brody, J A, Broeckel, U, Brumat, M, Burke, G, Cabrera, C P, Canouil, M, Chee, M L, Chen, Y D I, Cocca, M, Connell, J, de Silva, H J, de Vries, P S, Eiriksdottir, G, Faul, J D, Fisher, V, Forrester, T, Fox, E F, Friedlander, Y, Gao, H, Gigante, B, Giulianini, F, Gu, C C, Gu, D, Harris, T B, He, J, Heikkinen, S, Heng, C K, Hunt, S, Ikram, M A, Irvin, M R, Kähönen, M, Kavousi, M, Khor, C C, Kilpeläinen, T O, Koh, W P, Komulainen, P, Kraja, A T, Krieger, J E, Langefeld, C D, Li, Y, Liang, J, Liewald, D C M, Liu, C T, Liu, J, Lohman, K K, Mägi, R, McKenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mook-Kanamori, D O, Nalls, M A, Nelson, C P, Norris, J M, O’Connell, J, Ogunniyi, A, Padmanabhan, S, Palmer, N D, Pedersen, N L, Perls, T, Peters, A, Petersmann, A, Peyser, P A, Polasek, O, Porteous, D J, Raffel, L J, Rice, T K, Rotter, J I, Rudan, I, Rueda-Ochoa, O L, Sabanayagam, C, Salako, B L, Schreiner, P J, Shikany, J M, Sidney, S S, Sims, M, Sitlani, C M, Smith, J A, Starr, J M, Strauch, K, Swertz, M A, Teumer, A, Tham, Y C, Uitterlinden, A G, Vaidya, D, van der Ende, M Y, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Weir, D R, Wen, W, Yao, J, Yu, B, Yu, C, Yuan, J M, Zhao, W, Zonderman, A B, Becker, D M, Bowden, D W, Deary, I J, Dörr, M, Esko, T, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kammerer, C M, Kato, N, Lakka, T A, Leander, K, Lehtimäki, T, Magnusson, P K E, Marques-Vidal, P, Penninx, B W J H, Samani, N J, van der Harst, P, Wagenknecht, L E, Wu, T, Zheng, W, Zhu, X, Bouchard, C, Cooper, R S, Correa, A, Evans, M K, Gudnason, V, Hayward, C, Horta, B L, Kelly, T N, Kritchevsky, S B, Levy, D, Palmas, W R, Pereira, A C, Province, M M, Psaty, B M, Ridker, P M, Rotimi, C N, Tai, E S, van Dam, R M, van Duijn, C M, Wong, T Y, Rice, K, Gauderman, W J, Morrison, A C, North, K E, Kardia, S L R, Caulfield, M J, Elliott, P, Munroe, P B, Franks, P W, Rao, D C, Fornage, M & Lifelines Cohort Study 2021, ' Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci ', Molecular Psychiatry, vol. 26, no. 6, pp. 2111-2125 . https://doi.org/10.1038/s41380-020-0719-3
Molecular psychiatry, vol. 26, no. 6, pp. 2111-2125
de las Fuentes, L, Sung, Y J, Noordam, R, Winkler, T, Feitosa, M F, Schwander, K, Bentley, A R, Brown, M R, Guo, X, Manning, A, Chasman, D I, Aschard, H, Bartz, T M, Bielak, L F, Campbell, A, Cheng, C Y, Dorajoo, R, Hartwig, F P, Horimoto, A R V R, Li, C, Li-Gao, R, Liu, Y, Marten, J, Musani, S K, Ntalla, I, Rankinen, T, Richard, M, Sim, X, Smith, A V, Tajuddin, S M, Tayo, B O, Vojinovic, D, Warren, H R, Xuan, D, Alver, M, Boissel, M, Chai, J F, Chen, X, Christensen, K, Divers, J, Evangelou, E, Gao, C, Girotto, G, Harris, S E, He, M, Hsu, F C, Kühnel, B, Laguzzi, F, Li, X, Lyytikäinen, L P & Lifelines Cohort Study 2021, ' Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci ', Molecular Psychiatry, vol. 26, no. 6, pp. 2111-2125 . https://doi.org/10.1038/s41380-020-0719-3
Molecular Psychiatry, 26, 2111-2125. Nature Publishing Group

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554bda77ec4e9f3602722bf8e37ac4d7
https://doi.org/10.1038/s41380-020-0719-3

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.

Autor: Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K Lee, Davide Gentilini, Claire E Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M C Connell, Morris Brown, Nilesh J Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H Erich Wichmann, Maris Laan, David P Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D Spector, Gavin Lucas, Sekar Kathiresan, David S Siscovick, Jian'an Luan, Ruth J F Loos, Nicholas J Wareham, Brenda W Penninx, Ilja M Nolte, Martin McBride, William H Miller, Stuart A Nicklin, Andrew H Baker, Delyth Graham, Robert A McDonald, Jill P Pell, Naveed Sattar, Paul Welsh, Global BPgen Consortium, Patricia Munroe, Mark J Caulfield, Alberto Zanchetti, Anna F Dominiczak

Publikováno v: PLoS Genetics, Vol 6, Iss 10, p e1001177 (2010)

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existen

Externí odkaz: https://doaj.org/article/57807fab5b1d4659bc82c7a7a71fbacc

A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Autor: Bamidele O. Tayo, RJ Waken, Mario Sims, Diane M. Becker, Tõnu Esko, Yingchang Lu, Pamela J. Schreiner, Antonietta Robino, Anne U. Jackson, H. Janaka de Silva, Peter J. van der Most, Archie Campbell, Ozren Polasek, Salman M. Tajuddin, Jing Hua Zhao, Barbara V. Howard, Saima Afaq, Vilmundur Gudnason, Lynda M. Rose, Francis S. Collins, Massimiliano Cocca, Ruth J. F. Loos, Yii-Der Ida Chen, W. James Gauderman, Jaspal S. Kooner, Lawrence F. Bielak, Ulrich Broeckel, Anuradhani Kasturiratne, Melissa A. Richard, Tomohiro Katsuya, Nicola D. Kerrison, Tin Aung, Lisa de las Fuentes, Lynne E. Wagenknecht, Oscar H. Franco, Yongmei Liu, Eric Boerwinkle, Nana Matoba, Saskia P. Hagenaars, Rob M. van Dam, Tibor V. Varga, Nilesh J. Samani, Tangchun Wu, Thomas H. Mosley, Caroline Hayward, Joseph H. Lee, Frida Renström, Tamara B. Harris, Alena Stančáková, Adesola Ogunniyi, Wen Bin Wei, Lenore J. Launer, Marcus Dörr, Xiuqing Guo, Jennifer A. Smith, Terho Lehtimäki, Dan E. Arking, Fang-Chi Hsu, Karin Leander, Martin Farrall, Konstantin Strauch, Albert V. Smith, Richard S. Cooper, Chiea Chuen Khor, Changwei Li, James E. Hixson, Sami Heikkinen, David R. Weir, Pirjo Komulainen, Renée de Mutsert, Raymond Noordam, Ubaydah Nasri, Paul M. Ridker, C. Charles Gu, Tamuno Alfred, Jerome I. Rotter, Nora Franceschini, Nita G. Forouhi, Lihua Wang, Alanna C. Morrison, Jian-Min Yuan, Ching-Yu Cheng, Peter S. Braund, Paul Elliott, Gregory P. Wilson, Jianjun Liu, Xiaofeng Zhu, Markku Laakso, Christian Gieger, Yukihide Momozawa, Rainer Rettig, Carsten Oliver Schmidt, Amy R. Bentley, Wei Zhao, Ioanna Ntalla, Kenneth Rice, Yoichiro Kamatani, Andres Metspalu, Helen R. Warren, Yechiel Friedlander, Susan Redline, Kurt Lohman, Cornelia M. van Duijn, Aravinda Chakravarti, Traci M. Bartz, Sarah E. Harris, Yih Chung Tham, He Gao, Mike A. Nalls, Mathilde Boissel, Donna K. Arnett, Harold Snieder, James S. Pankow, Babatunde L. Salako, Laura J. Bierut, Tin Louie, Albertine J. Oldehinkel, Xueling Sim, Thomas Meitinger, Maris Alver, Claudia Langenberg, Stephen B. Kritchevsky, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Alexandre C. Pereira, Michael R. Brown, Karen Schwander, Charles Kooperberg, Blair H. Smith, Annette Peters, Fernando Pires Hartwig, Yanhua Zhou, Jie Yao, Alisa K. Manning, Keng-Hung Lin, Dennis O. Mook-Kanamori, Ervin R. Fox, Tuomo Rankinen, Timo A. Lakka, Charles N. Rotimi, Nicholette D. Palmer, Jiang He, Nicholas J. Wareham, Jingmin Liu, Yun Ju Sung, Cathy C. Laurie, Donald W. Bowden, Yong-Bing Xiang, Lisa R. Yanek, B. Kuhnel, Nancy L. Pedersen, Yajuan Wang, Ananda R. Wickremasinghe, Jonathan Marten, Yi-Jen Hung, Dabeeru C. Rao, Bernardo L. Horta, Joel D. Kaufman, Barry I. Freedman, Chuan Gao, Olli T. Raitakari, Reedik Mägi, Solomon K. Musani, Albert Hofman, Wanqing Wen, Heming Wang, Xiao-Ou Shu, Y Liu, Mark J. Caulfield, Meian He, Daniel I. Chasman, Carl D. Langefeld, Charumathi Sabanayagam, Bruce M. Psaty, Jasmin Divers, R. Graham Barr, Chew-Kiat Heng, Stella Aslibekyan, John M. Starr, Stefan Weiss, Anuj Goel, Tuomas O. Kilpeläinen, Terrence Forrester, Mary F. Feitosa, Jost B. Jonas, Kae-Woei Liang, Colleen M. Sitlani, Daniel Levy, Marie Loh, Qing Duan, Aldi T. Kraja, Tien Yin Wong, Myriam Fornage, Andrea R. V. R. Horimoto, Michele K. Evans, David J. Porteous, Dina Vojinovic, Hua Tang, Michael A. Province, Ching-Ti Liu, Rainer Rauramaa, William R. Scott, Cora E. Lewis, Charles B. Eaton, Sharon L.R. Kardia, Michael Boehnke, James Scott, Colin A McKenzie, Jin-Fang Chai, Woon-Puay Koh, Yucheng Jia, Claude Bouchard, Peter S. Sever, Koichi Matsuda, Najaf Amin, Ulf de Faire, Walter Palmas, André G. Uitterlinden, Thomas T. Perls, Erin B. Ware, Wayne Huey-Herng Sheu, Michiaki Kubo, Ya Xing Wang, Hugh Watkins, Steven C. Hunt, Weihua Zhang, Johanna Kuusisto, Lili Milani, Rajkumar Dorajoo, Georg Ehret, L. Adrienne Cupples, Franco Giulianini, Zoltán Kutalik, Jose E Krieger, Kevin Sandow, Bruna Gigante, Alexander P. Reiner, Preeti Gupta, Heikki A. Koistinen, Treva Rice, Patricia B. Munroe, Wen-Jane Lee, Jennifer A. Brody, Paolo Gasparini, Paul W. Franks, Yik Ying Teo, Leo-Pekka Lyytikäinen, Thomas W. Winkler, Patricia A. Peyser, Ian J. Deary, Jessica D. Faul, Sing Hui Lim, Fumihiko Takeuchi, Xu Chen, Brian E. Cade, Patrik K. E. Magnusson, John C. Chambers, Tamar Sofer, E. Shyong Tai, Candace M Kammerer, Mary K. Wojczynski, Pim van der Harst, Marzyeh Amini, Jennifer G. Robinson, Erwin P. Bottinger, Alan B. Zonderman, Benjamin Lehne, M. Waldenberger, Jeffrey R. O'Connell, Hugues Aschard, Ilaria Gandin, Kent D. Taylor, Igor Rudan, Christopher P. Nelson, John M. C. Connell, Jian'an Luan, Mickaël Canouil, Robert A. Scott, Yize Li, Marguerite R. Irvin

Publikováno v: Hum Mol Genet
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 2019, 28 (15), pp.2615-2633. ⟨10.1093/hmg/ddz070⟩
Human Molecular Genetics, 28(15), 2615-2633. Oxford University Press
Human Molecular Genetics, 28(15), 2615-2633. OXFORD UNIV PRESS
2019, ' A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddz070
Human Molecular Genetics, Vol. 28, No 15 (2019) pp. 2615-2633

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5654ae9b91f97c8df58b8fa976a56c73
https://europepmc.org/articles/PMC6644157/

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Autor: Tamara B. Harris, Niels Grarup, Marcus Dörr, Martina Müller-Nurasyid, Torben Hansen, Lu-Chen Weng, Honghuang Lin, Thibaud Boutin, Joshua C. Bis, Farid Radmanesh, Jie Yao, Nilesh J. Samani, Ozren Polašek, Massimo Mangino, Charles Kooperberg, Vilmundur Gudnason, Stephan B. Felix, Bruno H. Stricker, Elsayed Z. Soliman, Nathan A. Bihlmeyer, Jette Bork-Jensen, Dan E. Arking, J. Marten, Mika Kähönen, Kenneth Rice, Nona Sotoodehnia, Heather Jameson, Henry J. Lin, Jørgen K. Kanters, Jared W. Magnani, Mark Eijgelsheim, Hao Mei, Tim D. Spector, Oluf Pedersen, Allan Linneberg, G. Homuth, Chengping Wen, Olli T. Raitakari, Blair H. Smith, Marco V Perez, Melanie Waldenberger, Bram P. Prins, James G. Wilson, Xiuqing Guo, Sandosh Padmanabhan, Peter van der Meer, Stefan Weiss, Leo-Pekka Lyytikäinen, Colleen M. Sitlani, Alvaro Alonso, Leanne M. Hall, Cornelia M. van Duijn, Jessica van Setten, Helen R. Warren, Kent D. Taylor, Niek Verweij, Man Li, Moritz F. Sinner, Igor Rudan, Christopher P. Nelson, Emelia J. Benjamin, William J. Hucker, Marten E. van den Berg, Alan Hanley, Jerome I. Rotter, D. O. Mook-Kanamori, Susan R. Heckbert, Bruce M. Psaty, Caroline Hayward, Yalda Jamshidi, Patrick T. Ellinor, John M. C. Connell, Patricia B. Munroe, Lenore J. Launer, Stefan Kääb, Uwe Völker, Ruifang Li-Gao, Jan A. Kors, Annette Peters, J. Wouter Jukema, Jeffrey Haessler, Aaron Isaacs, Folkert W. Asselbergs, Rudolf A. de Boer, Konstantin Strauch, Albert V. Smith, Jonathan Rosand, Steven A. Lubitz, F. Rivadeneira, Nathan R. Tucker, Michiel L. Bots, Zhijun Xie, Jennifer A. Brody, Stella Trompet, Thomas Meitinger, André G. Uitterlinden, Pim van der Harst, Paul L. Huang, Henry Völzke, Terho Lehtimäki, Yii-Der Ida Chen

Publikováno v: Circulation. Genomic and precision medicine, 11(5):002037. LIPPINCOTT WILLIAMS & WILKINS
Circulation: Genomic and Precision Medicine, 11(5)
Circulation. Genomic and precision medicine, 11(5), e002037. Lippincott Williams and Wilkins Ltd.
Circulation-Genomic and Precision Medicine, 11(5):UNSP e002037. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, 11(5). Lippincott Williams and Wilkins Ltd.
Circ. Genom. Precis. Med. 11:e002037 (2018)
Circulation: Genomic and Precision Medicine, 11(5):e002037 . Lippincott Williams and Wilkins Ltd.
Lin, H, van Setten, J, Smith, A V, Bihlmeyer, N A, Warren, H, Brody, J, Radmanesh, F, Hall, L M, Grarup, N, Müller-Nurasyid, M & Rudan, I 2018, ' Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.117.002037

Background: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2952dff652b6a3112e28f261b5e5bb4d
https://doi.org/10.1161/circgen.117.002037

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Autor: Olle Melander, Niek Verweij, Uwe Völker, Morris A. Swertz, Seppo Koskinen, David Conen, Lars Lind, Rossella Sorice, Philippe Amouyel, Andres Metspalu, David J. Stott, Marty Larson, Francis S. Collins, Ozren Polasek, Paul F. O'Reilly, Albertine J. Oldehinkel, Evangelos Evangelou, Pekka Jousilahti, Michela Traglia, Tineka Blake, John Attia, Bruce M. Psaty, Massimo Mangino, Alison Pattie, Marco Brumat, Dorret I. Boomsma, Harry Campbell, Daniel I. Chasman, Tõnu Esko, Wei-Yu Lin, Rodney J. Scott, Marjo-Riitta Järvelin, Guillaume Paré, Adriana M. Hung, Marina Evangelou, Quang Tri Nguyen, Markus Perola, Kenneth Rice, Yong Qian, Antonietta Robino, Anne U. Jackson, Ian J. Deary, Mika Kähönen, Cristina Menni, Veronique Vitart, Igor Rudan, Ganesh Chauhan, Aravinda Chakravarti, Jennifer E. Huffman, John M. Starr, Anubha Mahajan, Christopher Newton-Cheh, Peter Almgren, Yuri Milaneschi, Jacklyn N. Hellwege, Roby Joehanes, Christopher P. Nelson, Eleftheria Zeggini, Elizabeth G. Holliday, Peter J. van der Most, Annette Peters, Paul M. Ridker, Michael Boehnke, Joris Deelen, Brenda W.J.H. Penninx, Neil Poulter, Renée de Mutsert, Rick Jansen, Fu Liang Ng, Anne-Claire Vergnaud, Ilja M. Nolte, Meixia Ren, Gail Davies, John M. C. Connell, Jian'an Luan, Todd L. Edwards, Benjamin Lehne, K. Witkowska, Lili Milani, Stéphanie Debette, Georgios Ntritsos, Claudia P. Cabrera, Paolo Gasparini, Jouke-Jan Hottenga, Antti-Pekka Sarin, Kelly Cho, Robert A. Scott, Veikko Salomaa, Niki Dimou, David C. Liewald, Pim van der Harst, Teemu J. Niiranen, Denis C. Shields, Leo-Pekka Lyytikäinen, Andrew P. Morris, Murielle Bochud, Helena Schmidt, Bernard Keavney, Christopher Oldmeadow, Ioanna Tzoulaki, Jaakko Tuomilehto, Louise V. Wain, Reedik Mägi, Christian Gieger, Caterina Barbieri, Aki S. Havulinna, Fabiola Del Greco M, Dragana Vuckovic, Alan F. Wright, J. Wouter Jukema, Reinhold Schmidt, Marcus Dörr, Franco Giulianini, Evan Tzanis, Erwin P. Bottinger, David Mosen-Ansorena, Ruth J. F. Loos, A. Mesut Erzurumluoglu, Teresa Nutile, Alice Stanton, Jun Ding, Yingchang Lu, Roberto Elosua, Walter Palmas, James F. Wilson, Edith Hofer, Giorgia Girotto, Bram P. Prins, Anna Morgan, Anuj Goel, Edward G. Lakatta, Alex S. F. Doney, Najaf Amin, Lenore J. Launer, Siim Sõber, Nicholas J. Wareham, Adam S. Butterworth, Ilaria Gandin, Xiuqing Guo, Kent D. Taylor, Andrew D. Morris, Paul Knekt, Cinzia Sala, Peter P. Pramstaller, Joshua C. Bis, Archie Campbell, Raha Pazoki, Hugh Watkins, Csaba P. Kovesdy, Yan V. Sun, Lynda M. Rose, Jaspal S. Kooner, Maciej Tomaszewski, Massimiliano Cocca, Claudia Langenberg, Gonneke Willemsen, Eco J. C. de Geus, Peter W.F. Wilson, Ahmad Vaez, Albert Hofman, Kristin L. Ayers, Sara M. Willems, Germaine C. Verwoert, Christophe Tzourio, Martin Farrall, Albert V. Smith, Joanna M. M. Howson, Daniela Toniolo, Digna R. Velez Edwards, Antti Jula, Stefan Enroth, Ruifang Li-Gao, Nabi Shah, Weihua Zhang, Paul Elliott, Dennis O. Mook-Kanamori, Tatijana Zemunik, Shih-Jen Hwang, Helen R. Warren, Peter J. Munson, He Gao, Ivana Kolcic, Peter S. Braund, Tamara B. Harris, Raymond Noordam, Stella Trompet, Markku Laakso, Peter K. Joshi, Zoltán Kutalik, Sébastien Thériault, Åsa Johansson, Rainer Rettig, Sarah H. Wild, Patricia B. Munroe, John Danesh, Anders Hamsten, Mark J. Caulfield, Gonçalo R. Abecasis, Praveen Surendran, Peter S. Sever, David S. Siscovick, Terho Lehtimäki, Priyanka Nandakumar, Aarno Palotie, Muralidharan Sargurupremraj, Chiara Batini, Nick Shrine, Harold Snieder, Cumhur Y Demirkale, Teresa Ferreira, André G. Uitterlinden, Sekar Kathiresan, Mattias Frånberg, Lorna M. Lopez, J. Michael Gaziano, Cornelia M. van Duijn, Maris Laan, Samuli Ripatti, John C. Chambers, Martin H. de Borst, Johan Sundström, Alan J. Gow, Caroline Hayward, Oscar H. Franco, Yongmei Liu, Sandosh Padmanabhan, Ibrahim Karaman, Georg Ehret, Cecilia M. Lindgren, Mike A. Nalls, Chrysovalanto Mamasoula, Daniela Ruggiero, Erik Ingelsson, Colin N. A. Palmer, Alan James, Elin Org, Kati Kristiansson, Alexander Teumer, Ulf Gyllensten, Joanne Knight, Vilmantas Giedraitis, Jerome I. Rotter, Yasaman Saba, Daniel Levy, Li Lin, Janina S. Ried, Michael R. Barnes, Harriëtte Riese, Andrew D. Johnson, David P. Strachan, Martin D. Tobin, Lorenz Risch, Rona J. Strawbridge, Jing Hua Zhao, Vilmundur Gudnason, Borbala Mifsud, Eric Boerwinkle, Catharina A. Hartman, Ben A. Oostra, Dan E. Arking, Andrew A. Hicks, Peter Vollenweider, Thibaud Boutin, Philip S. Tsao, Jie Yao, Ayush Giri, Marina Ciullo, Morris J. Brown, Alanna C. Morrison, Kay-Tee Khaw, Francesco Cucca, Jonathan Marten, Olli T. Raitakari, Christopher J. O'Donnell, Jaume Marrugat, Tim D. Spector, Heather J. Cordell, Nilesh J. Samani, Simon Thom, Sarah E. Harris

Publikováno v: Nature Genetics
Nature Genetics, 50(10), 1412-+. Nature Publishing Group
Nature genetics (Online) 50 (2018): 1412–1425. doi:10.1038/s41588-018-0205-x
info:cnr-pdr/source/autori:Evangelou E.; Warren H.R.; Mosen-Ansorena D.; Mifsud B.; Pazoki R.; Gao H.; Ntritsos G.; Dimou N.; Cabrera C.P.; Karaman I.; Ng F.L.; Evangelou M.; Witkowska K.; Tzanis E.; Hellwege J.N.; Giri A.; Velez Edwards D.R.; Sun Y.V.; Cho K.; Gaziano J.M.; Wilson P.W.F.; Tsao P.S.; Kovesdy C.P.; Esko T.; Magi R.; Milani L.; Almgren P.; Boutin T.; Debette S.; Ding J.; Giulianini F.; Holliday E.G.; Jackson A.U.; Li-Gao R.; Lin W.-Y.; Luan J.; Mangino M.; Oldmeadow C.; Prins B.P.; Qian Y.; Sargurupremraj M.; Shah N.; Surendran P.; Theriault S.; Verweij N.; Willems S.M.; Zhao J.-H.; Amouyel P.; Connell J.; de Mutsert R.; Doney A.S.F.; Farrall M.; Menni C.; Morris A.D.; Noordam R.; Pare G.; Poulter N.R.; Shields D.C.; Stanton A.; Thom S.; Abecasis G.; Amin N.; Arking D.E.; Ayers K.L.; Barbieri C.M.; Batini C.; Bis J.C.; Blake T.; Bochud M.; Boehnke M.; Boerwinkle E.; Boomsma D.I.; Bottinger E.P.; Braund P.S.; Brumat M.; Campbell A.; Campbell H.; Chakravarti A.; Chambers J.C.; Chauhan G.; Ciullo M.; Cocca M.; Collins F.; Cordell H.J.; Davies G.; Borst M.H.; Geus E.J.; Deary I.J.; Deelen J.; Del Greco M F.; Demirkale C.Y.; Dorr M.; Ehret G.B.; Elosua R.; Enroth S.; Erzurumluoglu A.M.; Ferreira T.; Franberg M.; Franco O.H.; Gandin I.; Gasparini P.; Giedraitis V.; Gieger C.; Girotto G.; Goel A.; Gow A.J.; Gudnason V.; Guo X.; Gyllensten U.; Hamsten A.; Harris T.B.; Harris S.E.; Hartman C.A.; Havulinna A.S.; Hicks A.A.; Hofer E.; Hofman A.; Hottenga J.-J.; Huffman J.E.; Hwang S.-J.; Ingelsson E.; James A.; Jansen R.; Jarvelin M.-R.; Joehanes R.; Johansson A.; Johnson A.D.; Joshi P.K.; Jousilahti P.; Jukema J.W.; Jula A.; Kahonen M.; Kathiresan S.; Keavney B.D.; Khaw K.-T.; Knekt P.; Knight J.; Kolcic I.; Kooner J.S.; Koskinen S.; Kristiansson K.; Kutalik Z.; Laan M.; Larson M.; Launer L.J.; Lehne B.; Lehtimaki T.; Liewald D.C.M.; Lin L.; Lind L.; Lindgren C.M.; Liu Y.M.; Loos R.J.F.; Lopez L.M.; Lu Y.; Lyytikainen L.-P.; Mahajan A.; Mamasoula C.; Marrugat J.; Marten J.; Milaneschi Y.; Morgan A.; Morris A.P.; Morrison A.C.; Munson P.J.; Nalls M.A.; Nandakumar P.; Nelson C.P.; Niiranen T.; Nolte I.M.; Nutile T.; Oldehinkel A.J.; Oostra B.A.; O'Reilly P.F.; Org E.; Padmanabhan S.; Palmas W.; Palotie A.; Pattie A.; Penninx B.W.J.H.; Perola M.; Peters A.; Polasek O.; Pramstaller P.P.; Nguyen Q.T.; Raitakari O.T.; Ren M.; Rettig R.; Rice K.; Ridker P.M.; Ried J.S.; Riese H.; Ripatti S.; Robino A.; Rose L.M.; Rotter J.I.; Rudan I.; Ruggiero D.; Saba Y.; Sala C.F.; Salomaa V.; Samani N.J.; Sarin A.-P.; Schmidt R.; Schmidt H.; Shrine N.; Siscovick D.; Smith A.V.; Snieder H.; Sober S.; Sorice R.; Starr J.M.; Stott D.J.; Strachan D.P.; Strawbridge R.J.; Sundstrom J.; Swertz M.A.; Taylor K.D.; Teumer A.; Tobin M.D.; Tomaszewski M.; Toniolo D.; Traglia M.; Trompet S.; Tuomilehto J.; Tzourio C.; Uitterlinden A.G.; Vaez A.; van der Most P.J.; van Duijn C.M.; Vergnaud A.-C.; Verwoert G.C.; Vitart V.; Volker U.; Vollenweider P.; Vuckovic D.; Watkins H.; Wild S.H.; Willemsen G.; Wilson J.F.; Wright A.F.; Yao J.; Zemunik T.; Zhang W.; Attia J.R.; Butterworth A.S.; Chasman D.I.; Conen D.; Cucca F.; Danesh J.; Hayward C.; Howson J.M.M.; Laakso M.; Lakatta E.G.; Langenberg C.; Melander O.; Mook-Kanamori D.O.; Palmer C.N.A.; Risch L.; Scott R.A.; Scott R.J.; Sever P.; Spector T.D.; van der Harst P.; Wareham N.J.; Zeggini E.; Levy D.; Munroe P.B.; Newton-Cheh C.; Brown M.J.; Metspalu A.; Hung A.M.; O'Donnell C.J.; Edwards T.L.; Psaty B.M.; Tzoulaki I.; Barnes M.R.; Wain L.V.; Elliott P.; Caulfield M.J./titolo:Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits/doi:10.1038%2Fs41588-018-0205-x/rivista:Nature genetics (Online)/anno:2018/pagina_da:1412/pagina_a:1425/intervallo_pagine:1412–1425/volume:50
Nature Genetics, 50(10), 1412-1431. Nature Publishing Group
Nature Genetics, Vol. 50, No 10 (2018) pp. 1412-1425
Keavney, B, Tomaszewski, M, Morris, A & et al 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x
Boomsma, D I, de Geus, E J C, Hottenga, J J, Willemsen, G & the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1431 . https://doi.org/10.1038/s41588-018-0205-x
the Million Veteran Program 2018, ' Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, no. 10, pp. 1412-1425 . https://doi.org/10.1038/s41588-018-0205-x
Nature Genetics, Nature Publishing Group, 2018, 50 (10), pp.1412-1425. ⟨10.1038/s41588-018-0205-x⟩
Nature Genetics, 50(10), 1412
Nature Genetics, 50(10), 1412-1425. Nature Publishing Group
Evangelou, E, Warren, H R, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera-Cardenas, C, Karaman, I, Liang Ng, F, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, J N, Giri, A, Velez Edwards, D R, Sun, Y V, Cho, K, Gaziano, J M, Wilson, P W F, Tsao, P S, Kovesdy, C P, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, E G, Jackson, A U, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, B P, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Theriault, S, Verweij, N, Willems, S M, Zhao, J H, Amouyel, P, Connell, J M C, de Mutsert, R, Doney, A S F, Farrall, M, Menni, C, Morris, A, Noordam, R, Paré, G, Poulter, N R, Shields, D C, Stanton, A V, Thom, S, Abecasis, G R, Amin, N, Arking, D E, Ayers, K L, Barbieri, C M, Batini, C, Bis, J C, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, D I, Bottinger, E P, Braund, P S, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, J C, Chauhan, G, Ciullo, M, Cocca, M, Collins, F S, Cordell, H J, Davies, G, de Borst, M H, Geus, E J C, Deary, I, Deelen, J, Del Greco, F M, Demirkale, Y, Dörr, M, Ehret, G B, Elosua, R, Enroth, S, Erzurumluoglu, A M, Ferreira, T, Frånberg, M, Franco, O H, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, A J, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, T B, Harris, S, Hartman, C A, Havulinna, A S, Hicks, A A, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, J E, Hwang, S-J, Ingelsson, E, James, A L, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, A D, Joshi, P, Jousilahti, P, Jukema, J W, Jula, A, Kähönen, M, Kathiresan, S, Keavney, B D, Khaw, K T, Knekt, P, Knight, J, Kolcic, I, Kooner, J S, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, L J, Lehne, B, Lehtimäki, T, Liewald, D, Lin, L, Lind, L, Lindgren, C M, Liu, Y, Loos, R J, Lopez, L, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, A P, Morrison, A C, Munson, P J, Nalls, M A, Nandakumar, P, Nelson, C P, Niiranen, T, Nolte, I M, Nutile, T, Oldehinkel, A J, Oostra, B A, O'Reilly, P F, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, B W J H, Perola, M, Peters, A, Polasek, O, Pramstaller, P P, Tri Nguyen, Q, Raitakari, O T, Ren, M, Rettig, R, Rice, K M, Ridker, P M, Ried, J S, Riese, H, Ripatti, S, Robino, A, Rose, L M, Rotter, J I, Rudan, I, Ruggiero, D, Saba, Y, Sala, C F, Salomaa, V, Samani, N J, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N R G, Siscovick, D S, Smith, A V, Snieder, H, Sõber, S, Sorice, R, Starr, J, Stott, D J, Strachan, D P, Strawbridge, R J, Sundstrom, J, Swertz, M A, Taylor, K D, Teumer, A, Tobin, M D, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, A G, Vaez, A, van der Most, P J, van Duijn, C M, Vergnaud, A-C, Verwoert, G C, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, S, Willemsen, G, Wilson, J, Wrightl, A F, Yao, J, Zemunik, T, Zhang, W, Attia, J, Butterworth, A S, Chasman, D I, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, J MM, Laakso, M, Lakatta, E G, Langenberg, C, Melander, O, Mook-Kanamori, D O, Palmer, C N A, Risch, L, Scott, R A, Scott, R J, Sever, P, Spector, T D, van der Harst, P, Wareham, N J, Zeggini, E, Levy, D, Munroe, P B, Newton-Cheh, C, Brown, M J, Metspalu, A, Hung, A M, O'Donnell, C J, Edwards, T L, Psaty, B M, Tzoulaki, I, Barnes, M R, Wain, L V, Elliott, P & Caulfield, M J 2018, ' Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits ', Nature Genetics, vol. 50, pp. 1412–1425 . https://doi.org/10.1038/s41588-018-0205-x
Nat Genet

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of Eur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a06251cd994facd1a491f245b8b67
https://doi.org/10.1038/s41588-018-0205-x