Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuroprotection Trial Cohort

Autor: Dennis E. Mayock, Semsa Gogcu, Mihai Puia-Dumitrescu, Dennis W.W. Shaw, Jason N. Wright, Bryan A. Comstock, Patrick J. Heagerty, Sandra E. Juul, Rajan Wadhawan, Sherry E. Courtney, Tonya Robinson, Kaashif A. Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F. LaGamma, L. Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D. Frantz, Janine Khan, Michael Weiss, Maureen M. Gilmore, Robin K. Ohls, Jean Lowe, Nishant Srinivasan, Jorge E. Perez, Victor McKay, Billy Thomas, Nahed Elhassan, Sarah Mulkey, Vivek K. Vijayamadhavan, Neil Mulrooney, Bradley Yoder, Jordan S. Kase, Jennifer Check, Erin Osterholm, Thomas George, Michael Georgieff, Camilia R. Martin, Deirdre O'Reilly, Raye-Ann deRegnier, Nicolas Porta, Catalina Bazacliu, Frances Northington, Raul Chavez Valdez, Patel Saurabhkumar, Magaly Diaz-Barbosa, Todd Richards, John B. Feltner, Isabella Esposito, Stephanie Hauge, Samantha Nikirk, Amy Silvia, Bailey Clopp, Debbie Ott, Ariana Franco Mora, Pamela Hedrick, Vicki Flynn, Andrea Wyatt, Emilie Loy, Natalie Sikes, Melanie Mason, Jana McConnell, Tiffany Brown, Henry Harrison, Denise Pearson, Tammy Drake, Jocelyn Wright, Debra Walden, Annette Guy, Jennifer Nason, Morgan Talbot, Kristen Lee, Sarah Penny, Terri Boles, Melanie Drummond, Katy Kohlleppel, Charmaine Kathen, Brian Kaletka, Shania Gonzales, Cathy Worwa, Molly Fisher, Tyler Richter, Alexander Ginder, Brixen Reich, Carrie Rau, Manndi Loertscher, Laura Cole, Kandace McGrath, Kimberlee Weaver Lewis, Jill Burnett, Susan Schaefer, Karie Bird, Clare Giblin, Rita Daly, Kristi Lanier, Kelly Warden, Jenna Wassenaar, Jensina Ericksen, Bridget Davern, Mary Pat Osborne, Neha Talele, Evelyn Obregon, Tiglath Ziyeh, Molly Clarke, Rachel E. Wegner, Palak Patel, Molly Schau, Annamarie Russow, Kelly Curry, Lisa Barnhart, Charlamaine Parkinson, Sandra Beauman, Mary Hanson, Elizabeth Kuan, Conra Backstrom Lacy, Edshelee M. Galvis, Susana Bombino, Denise Martinez, Suzi Bell, Corrie Long, Christopher Nefcy, Mark A. Konodi, Phuong T. Vu, Adam Hartman, T. Michael O'Shea, Roberta Ballard, Mike O'Shea, Karl Kuban, John Widness

Publikováno v: J Pediatr

Objectives To compare the term equivalent brain magnetic resonance imaging (MRI) findings between erythropoietin (Epo) treated and placebo control groups in infants 240/7-276/7 weeks of gestational age and to assess the associations between MRI findi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9040a25289f17d295ab49a14fa5e3fa
https://europepmc.org/articles/PMC9052881/

Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor

Autor: Sm, Zeng, Yankowitz J, John Widness, Rg, Strauss

Publikováno v: Europe PubMed Central

Males have a higher hematocrit (Hct) than females. The cause of this gender-based difference is unclear. We sought to determine whether polymorphisms of the erythropoietin (EPO) gene or of its receptor (EPOR) explain this situation.We designed primer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe232f7632fb19a8ec0140b9593fe8a7
https://pubmed.ncbi.nlm.nih.gov/11324238

Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants

Autor: Km, Shannon, Jf, Keith Rd, Wc, Mentzer, Ra, Ehrenkranz, Ms, Brown, John Widness, Ca, Gleason, Em, Bifano, Dd, Millard, Cb, Davis

Publikováno v: Europe PubMed Central

We hypothesized that treatment with recombinant human erythropoietin (r-HuEPO) would stimulate erythropoiesis and would thereby reduce the need for erythrocyte transfusions in preterm infants. We treated 157 preterm infants born at 26.9 +/- 1.6 weeks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::563251734e3414e72aec71feb26abcb2
https://pubmed.ncbi.nlm.nih.gov/7770317

The relationship between fetal arterial oxygen saturation and heart and skeletal muscle myoglobin concentrations in the ovine fetus

Autor: Sf, Guiang Rd, John Widness, Kb, Flanagan, Rl, Schmidt, Wj, Radmer, Mk, Georgieff

Publikováno v: Europe PubMed Central

Myoglobin, a hemoprotein found in abundance in the muscle of postnatal animals, increases in concentration in response to hypoxia, thereby protecting tissue from damage. Fetuses exposed to intrauterine hypoxemia are also susceptible to organ damage,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::df6dfb626cada7c050cc7a77572a0102
https://pubmed.ncbi.nlm.nih.gov/8089441

Lack of maternal to fetal transfer of 125I-labelled erythropoietin in sheep

Autor: John Widness, St, Sawyer, Rl, Schmidt, Dh, Chestnut

Publikováno v: Europe PubMed Central

We administered tracer quantities of biologically active 125I-labelled recombinant human erythropoietin by intravenous bolus injection to seven late gestation pregnant ewes. Maternal and fetal blood was sampled over the subsequent six hours and assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2cdc9b97811716ce7bd3c77f8d4670a0
https://pubmed.ncbi.nlm.nih.gov/1658114