Výsledky vyhledávání - "John, Wahren"

Akademický článek

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

Autor: Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem

Publikováno v: Journal of Lipid Research, Vol 48, Iss 4, Pp 944-951 (2007)

Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are only 1–2 μg/g brain tissue, we hypothesized that it is metabolized and subse

Externí odkaz: https://doaj.org/article/29855b943bef4c258274a21859ee3155

Zobrazit plný text záznamu

Akademický článek

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Autor: Maura Heverin, Steve Meaney, Dieter Lütjohann, Ulf Diczfalusy, John Wahren, Ingemar Björkhem

Publikováno v: Journal of Lipid Research, Vol 46, Iss 5, Pp 1047-1052 (2005)

Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugula

Externí odkaz: https://doaj.org/article/11447fbf52b84111a71954b3b98ffed5

Zobrazit plný text záznamu

Akademický článek

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Autor: Ingemar Björkhem, Dieter Lütjohann, Ulf Diczfalusy, Lars Ståhle, Gunvor Ahlborg, John Wahren

Publikováno v: Journal of Lipid Research, Vol 39, Iss 8, Pp 1594-1600 (1998)

We have previously demonstrated that the brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. Natl. Acad. Sci. USA

Externí odkaz: https://doaj.org/article/518eabf0fe1a47c2a596c3223487091a

Zobrazit plný text záznamu

Akademický článek

C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.

Autor: Dana Galuska, Sergej Pirkmajer, Romain Barrès, Karin Ekberg, John Wahren, Alexander V Chibalin

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28294 (2011)

Replacement of proinsulin C-peptide in type 1 diabetes ameliorates nerve and kidney dysfunction, conditions which are associated with a decrease in Na,K-ATPase activity. We determined the molecular mechanism by which long term exposure to C-peptide s

Externí odkaz: https://doaj.org/article/837ddbdde233428d82f75179412ae0c3

Zobrazit plný text záznamu

Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial

Autor: Howard Foyt, John Wahren, Mark Daniels, Joseph C. Arezzo

Publikováno v: Diabetes Care. 39:596-602

OBJECTIVE Lack of C-peptide in type 1 diabetes may be an important contributing factor in the development of microvascular complications. Replacement of native C-peptide has been shown to exert a beneficial influence on peripheral nerve function in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9390b06ff034d962a7c995075af8e40a
https://doi.org/10.2337/dc15-2068

Zobrazit plný text záznamu

The structure, molecular interactions and bioactivities of proinsulin C-peptide correlate with a tripartite molecule

Autor: Michael Landreh, Hans Jörnvall, John Wahren, Jan Johansson

Publikováno v: Biomolecular Concepts, Vol 5, Iss 2, Pp 109-118 (2014)

Many biological roles have been assigned to proinsulin C-peptide over the years. Some appear surprisingly disparate and sometimes even contradictory, like chaperone-like actions and depository tendencies. This review summarizes recently reported biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8007f09bbb98669d8fe5177c26718a
https://doaj.org/article/c475b7ed1bf0430286cd5681cb578f38

Zobrazit plný text záznamu

Enhanced insulin action following subcutaneous co-administration of insulin and C-peptide in rats

Autor: K. Ekberg, M. Kubota, John Wahren, Yuzo Sato, O. Khookhor, Alexander V. Chibalin

Publikováno v: Diabetes/Metabolism Research and Reviews. 30:124-131

Background This study was undertaken to examine if C-peptide (C) may interact with hexameric insulin and facilitate its disaggregation into the physiologically active monomeric form. Methods Regular insulin (I) or an insulin analogue (IA) were inject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a7126c5b145c8692f1a9b6fa20cad56
https://doi.org/10.1002/dmrr.2471

Zobrazit plný text záznamu

Can C-peptide mediated anti-inflammatory effects retard the development of microvascular complications of type 1 diabetes?

Autor: Åsa Kallas, Patrizia Luppi, John Wahren

Publikováno v: Diabetes/Metabolism Research and Reviews. 29:357-362

Hyperglycemia is considered to be the major cause of microvascular complications of diabetes. Growing evidence highlights the importance of hyperglycemia-mediated inflammation in the initiation and progression of microvascular complications in type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfac8a2c9ee2eb95e0bf9f10b0e53674
https://doi.org/10.1002/dmrr.2409

Zobrazit plný text záznamu

The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes

Autor: Anders A. F. Sima, John Wahren, Åsa Kallas

Publikováno v: Diabetes

It is well known that C-peptide fulfills an important function in the synthesis of insulin. After cleavage of proinsulin in the pancreatic β-cells, the 31-amino acid C-peptide is secreted into the portal circulation in equimolar concentrations with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19433d6743f74a2e47465ee8d8afea23
https://doi.org/10.2337/db11-1423

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání