Zobrazeno 1 - 3
of 3
pro vyhledávání: '"John, Tokarski"'
Autor:
Chetan Padmakar Darne, Upender Velaparthi, Mark Saulnier, David Frennesson, Peiying Liu, Audris Huang, John Tokarski, Aberra Fura, Thomas Spires, John Newitt, Vanessa M. Spires, Mary T. Obermeier, Paul A. Elzinga, Marco M. Gottardis, Lata Jayaraman, Gregory D. Vite, Aaron Balog
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
We report herein, the discovery of BMS-737 (compound 33) as a potent, non-steroidal, reversible small molecule inhibitor demonstrating 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase, as well as a clean xenobiotic CYP profile for the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b381cd62d83515de45641af7f6372
https://pubmed.ncbi.nlm.nih.gov/36031020
https://pubmed.ncbi.nlm.nih.gov/36031020
Autor:
Daniel P, O'Malley, Vijay, Ahuja, Brian, Fink, Carolyn, Cao, Cindy, Wang, Jesse, Swanson, Susan, Wee, Ashvinikumar V, Gavai, John, Tokarski, David, Critton, Anthony A, Paiva, Benjamin M, Johnson, Nicolas, Szapiel, Dianlin, Xie
Publikováno v:
ACS Med Chem Lett
[Image: see text] C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::032277c9e1cbed0a1c660a581d21d626
https://pubmed.ncbi.nlm.nih.gov/31620238
https://pubmed.ncbi.nlm.nih.gov/31620238
Autor:
Keith L. Constantine, Luciano Mueller, William J. Metzler, Patricia A. McDonnell, Gordon Todderud, Valentina Goldfarb, Yi Fan, John A. Newitt, Susan E. Kiefer, Mian Gao, David Tortolani, Wayne Vaccaro, John Tokarski
Publikováno v:
Journal of Medicinal Chemistry; Sep2008, Vol. 51 Issue 19, p6225-6229, 5p