Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John, Sapienza"'
Autor:
Deborah S. Mortensen, Sayee G. Hegde, Sophie M. Perrin-Ninkovic, Sogole Bahmanyar, Meg McCarrick, Roy Harris, Robert Hilgraf, Branden G. S. Lee, Jeff McKie, Lisa Nadolny, John Sapienza, Alice Collette, Sarah Cox, James C. Gamez, Jennifer L. Hensel, Xuequn Helen Hua, Jim Leisten, Heather K. Raymon, Tam Tran, Rama Krishna Narla
Publikováno v:
Medicinal Chemistry Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612328f1499c3dbf3b9a40a6048d43ce
https://doi.org/10.1007/s00044-023-03072-4
https://doi.org/10.1007/s00044-023-03072-4
Autor:
Kate Blease, Garth Ringheim, Eduardo Torres, Jeffrey Muir, Laurie LeBrun, Veronique Plantevin-Krenitsky, Ashutosh Kulkarni, Maria Celeridad, Eun Mi Hur, Hegde Sayee Gajanan, Dehua Huang, Brian E. Cathers, John Sapienza, Henry Chan, Brydon Bennett, Katerina Leftheris, Correa Matthew D, Zheng Liu, Deborah S Mortensen, Brandon Whitefield, Mercedes Delgado, Dan Cashion, Sogole Bahmanyar, Lisa Morrison, Roli Khattri, Jason Parnes, Stephen Norris, Roy Harris, Kelven Burnett, Joshua Hansen, Godrej Khambatta, Patrick Papa
Publikováno v:
Journal of Medicinal Chemistry. 64:11886-11903
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672263b7734f02d97c0fbbde493d920b
https://doi.org/10.1021/acs.jmedchem.1c00388
https://doi.org/10.1021/acs.jmedchem.1c00388
Autor:
Correa Matthew D, Rama K. Narla, Laurie LeBrun, Joshua Hansen, Antonia Lopez-Girona, John Sapienza, Brian E. Cathers, Gang Lu, Joseph R Piccotti, Weihong Zhang, Ammirante Massimo, Matt Alexander, Nagy Mark A, Dehua Huang, Yang Tang, Michael Pourdehnad
Publikováno v:
Journal of Medicinal Chemistry. 64:1835-1843
Acute myeloid leukemia (AML) is marked by significant unmet clinical need due to both poor survival and high relapse rates where long-term disease control for most patients with relapsed or refractory AML remain dismal. Inspired to bring novel therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3d102a603425d5ff745cadaf690f61
https://doi.org/10.1021/acs.jmedchem.0c01489
https://doi.org/10.1021/acs.jmedchem.0c01489
Autor:
Marta, Viñas, Nunzio, D'Anna, Adolfo, Guandalini, Michele, Capasso, Maurizio, Nocerino, Alessandra, Guerriero, John, Sapienza
Publikováno v:
The Canadian veterinary journal = La revue veterinaire canadienne. 60(2)
An 18-month-old intact female lioness (Panthera leo) was referred to the Clinica Veterinaria Roma Sud for evaluation of bilateral cataracts. Phacoemulsification and implantation of +30 diopter intraocular lens (IOL) were performed bilaterally. Seven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a4df8874c4e97d8d6cd35cbac5894c2
https://pubmed.ncbi.nlm.nih.gov/30705456
https://pubmed.ncbi.nlm.nih.gov/30705456
Autor:
Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
Publikováno v:
Journal of Medicinal Chemistry. 58:5599-5608
We report here the synthesis and structure-activity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors. SAR studies examining the potency, selectivity, and PK parameters for a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4246303bd0bfbb72482c44adc512f
https://doi.org/10.1021/acs.jmedchem.5b00627
https://doi.org/10.1021/acs.jmedchem.5b00627
Autor:
Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
Publikováno v:
Journal of Medicinal Chemistry. 58:5323-5333
We report here the synthesis and structure-activity relationship (SAR) of a novel series of mammalian target of rapamycin (mTOR) kinase inhibitors. A series of 4,6- or 1,7-disubstituted-3,4-dihydropyrazino[2,3-b]pyrazine-2(1H)-ones were optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45fdcea6d9d36fd9f5e210e377f686
https://doi.org/10.1021/acs.jmedchem.5b00626
https://doi.org/10.1021/acs.jmedchem.5b00626
Autor:
Laurence Occelli, Kelli L Combs, Jenny M Novak, Terry W. Lehenbauer, Allison Hoffman, Joe Wolfer, John Sapienza, Kricket A. Konrade
Publikováno v:
American Journal of Veterinary Research. 73:1299-1304
Objective—To evaluate the refractive error induced by intraocular administration of silicone oil (SiO) in dogs. Animals—47 client-owned dogs evaluated for blindness secondary to retinal detachment. Procedures—3-port pars plana vitrectomy with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fb65a2da5c3737641451e807a60bb3
https://doi.org/10.2460/ajvr.73.8.1299
https://doi.org/10.2460/ajvr.73.8.1299
Autor:
Matt Hickman, Sophie X. Peng, Graziella I. Shevlin, Rama K. Narla, Jim Leisten, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Gody Khambatta, Jim Gamez, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Jason Simon Parnes, Roy L. Harris, Kimberly Elizabeth Fultz
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(6)
We report here the discovery of a novel series of selective mTOR kinase inhibitors and the identification of CC214-2, a compound with demonstrated anti-tumor activity upon oral dosing in a PC3 prostate cancer xenograft model. A series of 4,6-disubsti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdc91ae4cde7b8f11356648cc67d4d5
https://pubmed.ncbi.nlm.nih.gov/23414803
https://pubmed.ncbi.nlm.nih.gov/23414803
Autor:
Li Xu, Meg Mccarrick, Neil R. D'sidocky, Veronique Plantevin Krenitsky, Lisa Nadolny, Yoshitaka Satoh, April Bai, Sayee G. Hegde, Brian E. Cathers, Jonathan Wright, Ronald Albers, John Sapienza, Steven S. Clareen, David Giegel, Rachel Fan, Robert Hilgraf, Michael A. Shirley, Heather Raymon, Maria Celeridad, Leticia Ayala, Jason Katz, Philip P Chamberlain, Brent Benish, Brydon L. Bennett, Tracey Bodine, Mercedes Delgado, Sogole Bahmanyar, Mehran F. Moghaddam, Silvia L. Delker, Yang Tang, Kate Blease, Oleg Khatsenko, Jeff Lachowitzer, Jeff Muir
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
In this Letter we describe the discovery of potent, selective, and orally active aminopurine JNK inhibitors. Improving the physico-chemical properties as well as increasing the potency and selectivity of a subseries with rat plasma exposure, led to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ea10690da2ff079cc5267cb8ef0dd6
https://pubmed.ncbi.nlm.nih.gov/22244937
https://pubmed.ncbi.nlm.nih.gov/22244937
Autor:
Adam Kois, Normand Richard, Khammungkhune Sak, Graziella I. Shevlin, Shripad S. Bhagwat, John Sapienza, Helen Brady, Mathew Hickman, Jalluri Ravi Kumar, Deborah Mortensen, Gayo Leah M, Jeffrey A. Mckie, Mary Doubleday, May S Kung Sutherland, Bernd Stein
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
Starting from a phenol screening hit (6), three series of benzopyranone selective estrogen receptor modulators (SERMs) have been designed, synthesized, and analyzed for both estrogen receptor alpha binding affinity and in vitro activity in two cell a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5671bfae4e2deb683ad3fb739f4caaed
https://pubmed.ncbi.nlm.nih.gov/15177442
https://pubmed.ncbi.nlm.nih.gov/15177442