Zobrazeno 1 - 10
of 17
pro vyhledávání: '"John, Rugis"'
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1455 (2022)
The cytosolic concentration of free calcium ions ([Ca2+]) is an important intracellular messenger in most cell types, and the spatial distribution of [Ca2+] is often critical. In a salivary gland acinar cell, a polarised epithelial cell, whose princi
Externí odkaz:
https://doaj.org/article/8503e13b1f304b36aedd4cc8487ccdb4
Autor:
Takahiro Takano, Amanda M Wahl, Kai-Ting Huang, Takanori Narita, John Rugis, James Sneyd, David I Yule
Publikováno v:
eLife, Vol 10 (2021)
Salivary fluid secretion involves an intricate choreography of membrane transporters to result in the trans-epithelial movement of NaCl and water into the acinus lumen. Current models are largely based on experimental observations in enzymatically is
Externí odkaz:
https://doaj.org/article/70400a41f69e4069aa4ae68cad70958b
Publikováno v:
Bulletin of Mathematical Biology. 84
Saliva is produced in two stages in the salivary glands: the secretion of primary saliva by the acinus and the modification of saliva composition to final saliva by the intercalated and striated ducts. In order to understand the saliva modification p
Publikováno v:
Bulletin of Mathematical Biology. 81:1394-1426
We have constructed a spatiotemporal model of $$\hbox {Ca}^{2+}$$ dynamics in parotid acinar cells, based on new data about the distribution of inositol trisphophate receptors (IPR). The model is solved numerically on a mesh reconstructed from images
Publikováno v:
Bull Math Biol
Saliva is secreted from the acinar cells of the salivary glands, using mechanisms that are similar to other types of water-transporting epithelial cells. Using a combination of theoretical and experimental techniques, over the past 20 years we have c
Salivary fluid secretion involves an intricate choreography to result in the trans-epithelial movement of NaCl and water into the acinus lumen. Current models are based on experimental observations in enzymatically isolated cells where the Ca2+signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41690738027e37425eeadd8dd48ab693
https://doi.org/10.1101/2020.12.30.424864
https://doi.org/10.1101/2020.12.30.424864
Publikováno v:
Journal of Theoretical Biology. 419:383-393
We construct a model of calcium waves in a three-dimensional anatomically accurate parotid acinar cell, constructed from experimental data. Gradients of inositol trisphosphate receptor (IPR) density are imposed, with the IPR density being greater clo
Publikováno v:
Bulletin of mathematical biology. 82(3)
We construct a three-dimensional anatomically accurate multicellular model of a parotid gland acinus to investigate the influence that the topology of its lumen has on primary fluid secretion. Our model consists of seven individual cells, coupled via
Publikováno v:
Bull Math Biol
We have constructed a spatiotemporal model of [Formula: see text] dynamics in parotid acinar cells, based on new data about the distribution of inositol trisphophate receptors (IPR). The model is solved numerically on a mesh reconstructed from images