Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John, Neidhardt"'
Autor:
Lars Möller, Yevhen Vainshtein, Bettina Meyer, John Neidhardt, A. Murat Eren, Kai Sohn, Ralf Rabus
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTWith almost a quadrillion individuals, the Antarctic krill processes five million tons of organic carbon every day during austral summer. This high carbon flux requires a broad range of hydrolytic enzymes to decompose the diverse food-derived
Externí odkaz:
https://doaj.org/article/aa27de90eedd4922b04ee9126e7e94e2
Autor:
Ramona Buschen, Pia Lambertus, Sabine Scheve, Simon Horst, Fei Song, Lars Wöhlbrand, John Neidhardt, Michael Winklhofer, Tristan Wagner, Ralf Rabus
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Aromatoleum aromaticum EbN1T anaerobically degrades phenol, p-cresol, and p-ethylphenol, each via a distinct peripheral pathway. The compound-specific regulation of each pathway is proposed to occur on the transcriptional level in the case o
Externí odkaz:
https://doaj.org/article/65cb08c5cf71405badded48ac0444d22
Autor:
Luba Farberov, Daphna Weissglas-Volkov, Guy Shapira, Yazeed Zoabi, Chen Schiff, Barbara Kloeckener-Gruissem, John Neidhardt, Noam Shomron
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107723- (2023)
Summary: Splicing of transcripts is catalyzed by the spliceosome, a mega-complex consisting of hundreds of proteins and five snRNAs, which employs direct interactions. When U1 snRNA forms high-affinity binding, namely more than eight base pairs, with
Externí odkaz:
https://doaj.org/article/bb769257d63b4f508d745126815368d4
Autor:
Christoph Jüschke, Thomas Klopstock, Claudia B. Catarino, Marta Owczarek-Lipska, Bernd Wissinger, John Neidhardt
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1186-1197 (2021)
Autosomal dominant optic atrophy (ADOA) is frequently caused by mutations in the optic atrophy 1 (OPA1) gene, with haploinsufficiency being the major genetic pathomechanism. Almost 30% of the OPA1-associated cases suffer from splice defects. We ident
Externí odkaz:
https://doaj.org/article/a11ea567c94342c38da3cd307ffe83ad
Autor:
Sebastian Swirski, Oliver May, Malte Ahlers, Bernd Wissinger, Martin Greschner, Christoph Jüschke, John Neidhardt
Publikováno v:
Cells, Vol 12, Iss 6, p 955 (2023)
Efficacy and safety considerations constitute essential steps during development of in vivo gene therapies. Herein, we evaluated efficacy and safety of splice factor-based treatments to correct mutation-induced splice defects in an Opa1 mutant mouse
Externí odkaz:
https://doaj.org/article/38d7d37af2a440cab3ab5e7ec94621ad
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 123-130 (2019)
Manipulation of pre-mRNA processing is a promising approach toward overcoming disease-causing mutations and treating human diseases. We show that a combined treatment applying two splice-manipulating technologies improves therapeutic efficacies to co
Externí odkaz:
https://doaj.org/article/74d2e42aad1243f58059fb9674fc0ac2
Autor:
Anna-Maria Neßlauer, Anne Gläser, Markus Gräler, Robby Engelmann, Brigitte Müller-Hilke, Marcus Frank, Christine Burstein, Arndt Rolfs, John Neidhardt, Andreas Wree, Martin Witt, Anja U. Bräuer
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-18 (2019)
Abstract Background Niemann-Pick disease type C1 (NPC1) is an autosomal-recessive lipid-storage disorder with an estimated minimal incidence of 1/120,000 live births. Besides other neuronal and visceral symptoms, NPC1 patients develop spleen dysfunct
Externí odkaz:
https://doaj.org/article/a0419c4954524ee0a8181407b24c077c
Autor:
Fenja Markus, Chloé Angelini, Aurelien Trimouille, Gabrielle Rudolf, Gaetan Lesca, Cyril Goizet, Eulalie Lasseaux, Benoit Arveiler, Marjon vanSlegtenhorst, Alice S. Brooks, Rami Abou Jamra, Georg‐Christoph Korenke, John Neidhardt, Marta Owczarek‐Lipska
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Abstract Background Epilepsy belongs to a group of chronic and highly heterogeneous brain disorders. Many types of epilepsy and epileptic syndromes are caused by genetic factors. The neural amino acid y‐aminobutyric acid (GABA) is a major inhibitor
Externí odkaz:
https://doaj.org/article/2953f38a05f94b3ba93aa65cf0fdc85f
Autor:
Bernd Wissinger, Christoph Jüschke, Thomas Klopstock, Marta Owczarek-Lipska, John Neidhardt, Claudia B. Catarino
Publikováno v:
Molecular Therapy / Nucleic Acids 26, 1186-1197 (2021). doi:10.1016/j.omtn.2021.10.019
Molecular therapy-Nucleic acids, 26, 1186-1197. Elsevier
Molecular Therapy: Nucleic Acids, Vol 26, Iss, Pp 1186-1197 (2021)
Molecular therapy-Nucleic acids, 26, 1186-1197. Elsevier
Molecular Therapy: Nucleic Acids, Vol 26, Iss, Pp 1186-1197 (2021)
Autosomal dominant optic atrophy (ADOA) is frequently caused by mutations in the optic atrophy 1 (OPA1) gene, with haploinsufficiency being the major genetic pathomechanism. Almost 30% of the OPA1-associated cases suffer from splice defects. We ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294188787a8003d0c56a232abb25346e
https://doi.org/10.1016/j.omtn.2021.10.019
https://doi.org/10.1016/j.omtn.2021.10.019
Publikováno v:
Genes. 13(11)
TARP syndrome (Talipes equinovarus, Atrial septal defect, Robin sequence, and Persistence of the left superior vena cava) is a rare genetic condition, caused by developmental defects during embryogenesis. The phenotypic spectrum of TARP shows high cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a99c14b059ee3940ede31b686a5bb1a3
https://pubmed.ncbi.nlm.nih.gov/36421828
https://pubmed.ncbi.nlm.nih.gov/36421828