Zobrazeno 1 - 10
of 94
pro vyhledávání: '"John, Malysz"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Non‐selective cation channels in urinary bladder smooth muscle (UBSM) are thought to mediate increases in cellular excitability and contractility. For transient receptor potential melastatin type‐4 (TRPM4) channels, the evidence primaril
Externí odkaz:
https://doaj.org/article/3c7f3516c8264b6eb271e63db31822a6
Publikováno v:
Physiological Reports, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract During development, maturation, or aging, the expression and function of urinary bladder smooth muscle (UBSM) ion channels can change, thus affecting micturition. Increasing evidence supports a novel role of transient receptor potential mela
Externí odkaz:
https://doaj.org/article/af37feac4b4544f29af834fdc22a2ecd
Autor:
John Malysz, Georgi V. Petkov
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of mu
Externí odkaz:
https://doaj.org/article/eab1af5c8d3c4c08b3e478c3b72aa01a
Publikováno v:
American Journal of Physiology-Cell Physiology. 317:C1268-C1277
Cl−channels serve as key regulators of excitability and contractility in vascular, intestinal, and airway smooth muscle cells. We recently reported a Cl−conductance in detrusor smooth muscle (DSM) cells. Here, we used the whole cell patch-clamp t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6aaeb203e44d4f0f2e4f8343224ad33
https://doi.org/10.1152/ajpcell.00189.2019
https://doi.org/10.1152/ajpcell.00189.2019
Publikováno v:
American Journal of Physiology-Cell Physiology. 316:C698-C710
Multiple types of Cl− channels regulate smooth muscle excitability and contractility in vascular, gastrointestinal, and airway smooth muscle cells. However, little is known about Cl− channels in detrusor smooth muscle (DSM) cells. Here, we used i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2adeffb72cfb6aa241c0a94b851d0d4b
https://doi.org/10.1152/ajpcell.00327.2018
https://doi.org/10.1152/ajpcell.00327.2018
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5904c57abb691556368508703763215a
https://doi.org/10.1096/fasebj.2021.35.s1.04481
https://doi.org/10.1096/fasebj.2021.35.s1.04481
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75875 (2013)
Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expres
Externí odkaz:
https://doaj.org/article/841000e8948b418b863d2d61a445791c
Autor:
John Malysz, Georgi V. Petkov
Publikováno v:
Am J Physiol Renal Physiol
Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the bladder wall and ultimately determines the two main attributes of the organ: urine storage and voiding. The two functions are facilitated by UBSM relaxation and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a2ef21522e8df431418b4c5bda359e
https://pubmed.ncbi.nlm.nih.gov/32628539
https://pubmed.ncbi.nlm.nih.gov/32628539
Publikováno v:
Journal of visualized experiments : JoVE
Detrusor smooth muscle (DSM) cells present within the urinary bladder wall ultimately facilitate urine storage and voiding. Preparation of the viable, fresh, and isolated DSM cells presents an important technical challenge whose achievement provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb56af13af500d13d4bc20dfaeb37e7
https://doi.org/10.3791/59884
https://doi.org/10.3791/59884
Autor:
David R. Linden, Siva Arumugam Saravanaperumal, Lei Sha, Simon J. Gibbons, John Malysz, Gianrico Farrugia, Joseph H. Szurszewski
Publikováno v:
Experimental Physiology. 103:40-57
New Findings What is the central question of this study? The aim was to investigate the roles of extracellular chloride in electrical slow waves and resting membrane potential of mouse jejunal smooth muscle by replacing chloride with the impermeant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb155e190242cf104831bc60193f777
https://doi.org/10.1113/ep086367
https://doi.org/10.1113/ep086367