Zobrazeno 1 - 10
of 1 815
pro vyhledávání: '"John, Gordon"'
Autor:
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Pol
Externí odkaz:
https://doaj.org/article/a588334634d94054a3dac469d64b47e7
Autor:
Greg Knoll, Bram Rochwerg, François Lauzier, Marat Slessarev, Michaël Chasse, Karen E A Burns, Alexis F Turgeon, John Gordon Boyd, Frédérick D'Aragon, Shane English, Matthew Weiss, Maureen Meade, Sonny Dhanani, Marie-Hélène Masse, François-Martin Carrier, Steven Hanna, Andrew Healey, Simon J W Oczkowski, Anne-Julie Frenette, Anique Ducharme, Prosanto Chaudhury, Markus Selzner, Ruth Breau, Mélanie Masse, Héloïse Cardinal, Brigitte Bolduc, Caroline Lamarche, Etienne Couture, Sandra Holdsworth, Liz Bertholz, Heather Talbot, Patrick Luke, M Khaled Shamseddin, Jeffrey Zaltzman, Darin Treleaven
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Most solid organ transplants originate from donors meeting criteria for death by neurological criteria (DNC). Within the organ donor, physiological responses to brain death increase the risk of ischaemia reperfusion injury and delayed gr
Externí odkaz:
https://doaj.org/article/0da023b6c5d4443aad540ffec3e61c6c
Autor:
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti
Externí odkaz:
https://doaj.org/article/892c78200eb14c6280a512cb5e5194fd
Autor:
Stella Cochrane, Ramya Rajagopal, David Sheffield, Fay Stewart, Lindsay Hathaway, Nicholas M. Barnes, Omar Qureshi, John Gordon
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: In toxicology, steps are being taken towards more mechanism-focused and human relevant approaches to risk assessment, requiring new approaches and methods. Additionally, there is increasing emphasis by regulators on risk assessment of i
Externí odkaz:
https://doaj.org/article/f4cb27fd0f7340f38632140be550ef16
Autor:
John Muscedere, Andrew Day, David M Maslove, Joanna S Semrau, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Patrick A Norman, Nicola E Symonds, Eric X M Meng, Hailey Hobbs
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Background Critically ill patients are at high risk of acquiring ventilator-associated pneumonia (VAP), which occurs in approximately 20% of mechanically ventilated patients. VAP results either from aspiration of pathogen-contaminated oropharyngeal s
Externí odkaz:
https://doaj.org/article/28f894ccaeb34e03ae742645c773e3a0