Zobrazeno 1 - 10
of 55
pro vyhledávání: '"John, Goodchild"'
Autor:
John Goodchild
Publikováno v:
Expert Opinion on Therapeutic Targets. 6:235-247
Expensive failures in the pharmaceutical industry might be avoided by target validation at an early stage. Often, the full consequences of inhibiting a chosen drug target do not emerge until late in the development process. One option is to use hamme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d499cb92e0dedaf15f127b69bcc3999
https://doi.org/10.1517/14728222.6.2.235
https://doi.org/10.1517/14728222.6.2.235
Autor:
Lina Prasmickaite, Øystein Fodstad, John Goodchild, Kristian Berg, Anders Høgset, Gunhild Mari Mælandsmo, Thomas A. Perkins, Eivind Hovig
Publikováno v:
Nucleic Acids Research. 26:4241-4248
The uptake and cellular metabolism of a fluorescein-labelled synthetic ribozyme stabilized by 2'- O -methyl modification and a 3' inverted thymidine have been studied, employing capillary gel electrophoresis as a novel and efficient analytical method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcde6be51b1e85aaa97e7990e883c388
https://doi.org/10.1093/nar/26.18.4241
https://doi.org/10.1093/nar/26.18.4241
Publikováno v:
Biochemistry. 35:16370-16377
A defining characteristic of catalysts is the rate at which they can process multiple copies of substrate. In the case of synthetic hammerhead ribozymes that cleave an RNA sequence, binding of the ribozyme to the substrate and products is through bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1169412ef3403e8bb923e94b7657f628
https://doi.org/10.1021/bi961234r
https://doi.org/10.1021/bi961234r
Autor:
John Goodchild, A. Kirk Field
Publikováno v:
Expert Opinion on Investigational Drugs. 4:799-821
During the seventeen years since the Zamecnik and Stephenson report [77] of antisense oligonucleotide activity, the literature describing efficacy in cell culture and animals has mushroomed. The technology has become far more sophisticated with the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718162542b1811da73088a213a197964
https://doi.org/10.1517/13543784.4.9.799
https://doi.org/10.1517/13543784.4.9.799
Publikováno v:
Nucleic Acids Research. 22:632-638
Approximately 80% of the DNA ligase activity in HeLa cell extracts is associated with the 21 S enzyme complex that functions in simian virus 40 DNA replication in vitro (Malkas et al., Biochemistry 29, 6362-6374., 1990). The DNA ligase associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf5d7b1ad8666ba4b8a51eea88e996c
https://doi.org/10.1093/nar/22.4.632
https://doi.org/10.1093/nar/22.4.632
Autor:
John Goodchild
Publikováno v:
Methods in Molecular Biology ISBN: 9781617791871
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adb5bc4c1d4964e1169f43ca7b653eb
https://doi.org/10.1007/978-1-61779-188-8_1
https://doi.org/10.1007/978-1-61779-188-8_1
Autor:
John Goodchild
Publikováno v:
Nucleic Acids Research. 20:4607-4612
RNA catalysts (ribozymes) designed to cleave sequences unique to viral RNA's might be developed as therapeutics. For this purpose, they would require high catalytic efficiency and resistance to nucleases. Reported here are two approaches that can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f0c08e70d427253edf17d82eadea85
https://doi.org/10.1093/nar/20.17.4607
https://doi.org/10.1093/nar/20.17.4607
Publikováno v:
British Journal of Theological Education. 4:48-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e0e309a99162f709e89516a6c4b965
https://doi.org/10.1080/1352741x.1991.11673989
https://doi.org/10.1080/1352741x.1991.11673989
Publikováno v:
Antisense Research and Development. 1:153-160
A 32P-labeled oligodeoxynucleotide of 20 bases was found to be quite stable in freshly drawn rabbit or human blood and no degradation was apparent within 2 hr. In contrast, following injection into rabbits, the same oligodeoxynucleotide was cleared f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563fa4bad732e91b94ec7fb31e6b1fca
https://doi.org/10.1089/ard.1991.1.153
https://doi.org/10.1089/ard.1991.1.153
Autor:
John, Goodchild
Publikováno v:
Current opinion in molecular therapeutics. 10(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a1ee3a873952bf7dc48fa4ba786b84
https://pubmed.ncbi.nlm.nih.gov/18386221
https://pubmed.ncbi.nlm.nih.gov/18386221