Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John, Finnie"'
Autor:
Joanne Bowen, Sofia Braga, Valeria Dal Zotto, John Finnie, Daniel DiPrimeo, Blaire Cooke, Georg F. Bischof, Alvin Wong, Jack A. Di Palma
Publikováno v:
Physiological Reports, Vol 12, Iss 16, Pp n/a-n/a (2024)
Abstract The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuatio
Externí odkaz:
https://doaj.org/article/4ac23f911fbd43ba915c155b47741514
Autor:
Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2023)
Abstract Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft
Externí odkaz:
https://doaj.org/article/e79655148af34996b2fadab1d06fecb9
Autor:
Stephen McIlfatrick, Sean O’Leary, Takashi Okada, Alexander Penn, Vy Hoang Thao Nguyen, Lisa McKenny, Shang-Yu Huang, Eryk Andreas, John Finnie, Roy Kirkwood, Justin C. St. John
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105956- (2023)
Summary: Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor quality oocytes. However, supplementation alters DNA methylation and gene expression profiles of preimplantation embryos. To determine if these alterat
Externí odkaz:
https://doaj.org/article/7b6448c8647746d19f6f8e96be21b5f6
Autor:
Timothy Luke Surman, John Matthew Abrahams, Jim Manavis, John Finnie, Chris Christou, Georgia Kate Williams, Angela Walls, Peter Frantzis, Mark Adams, James Edwards, Michael George Worthington, John Beltrame
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background In our earlier study on the functional limits of the aneurysmal aortic root we determined the pig root is susceptible to failure at high aortic pressures levels. We established a pig rupture model using cardiopulmonary bypass to d
Externí odkaz:
https://doaj.org/article/15fb9d2be38444c998ae5f9e594163fa
Autor:
Timothy Luke Surman, John Matthew Abrahams, Jim Manavis, John Finnie, Dermot O’Rourke, Karen Jane Reynolds, James Edwards, Michael George Worthington, John Beltrame
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Although aortic root and ascending aortic aneurysms are treated the same, they differ in embryological development and pathological processes. This study examines the microscopic structural differences between aortic root and asce
Externí odkaz:
https://doaj.org/article/931c09c683a54ddd9078c2e173009ffc
Autor:
Ahad Sabab, Rajan Sundaresan Vediappan, John Finnie, C. John McAdam, Alistair Jukes, Sarah Vreugde, Peter-John Wormald
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
BackgroundIntraoperative hemorrhage is a major cause of poor post-operative outcome. Beta-chitin patch has previously been found to be an effective haemostat, but whether modifying the patch can improve its efficacy and safety, remains unknown. In th
Externí odkaz:
https://doaj.org/article/b8d34460ce7c4e3e8210e20555d3b6d7
Autor:
Behnam Rashidieh, Belal Shohayeb, Amanda Louise Bain, Patrick R. J. Fortuna, Debottam Sinha, Andrew Burgess, Richard Mills, Rachael C. Adams, J. Alejandro Lopez, Peter Blumbergs, John Finnie, Murugan Kalimutho, Michael Piper, James Edward Hudson, Dominic C. H. Ng, Kum Kum Khanna
Publikováno v:
PLoS Genetics, Vol 17, Iss 10 (2021)
Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has previously been studied as a cruci
Externí odkaz:
https://doaj.org/article/ca113dc23d2f42909600bf1b070bc7e6
Autor:
Rajan Sundaresan Vediappan, Catherine Bennett, Clare Cooksley, John Finnie, Markus Trochsler, Ryan D Quarrington, Claire F Jones, Ahmed Bassiouni, Stephen Moratti, Alkis J Psaltis, Guy Maddern, Sarah Vreugde, P J Wormald
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244503 (2021)
IntroductionAdhesions are often considered to be an inevitable consequence of abdominal and pelvic surgery, jeopardizing the medium and long-term success of these procedures. Numerous strategies have been tested to reduce adhesion formation, however,
Externí odkaz:
https://doaj.org/article/7b15548deba544ffacddb76d3c8f8bf4
Autor:
Rajan Sundaresan Vediappan, Catherine Bennett, Ahmed Bassiouni, Matthew Smith, John Finnie, Markus Trochsler, Alkis J. Psaltis, Sarah Vreugde, Peter J. Wormald
Publikováno v:
Frontiers in Surgery, Vol 7 (2020)
Background: Adhesion formation after abdominal surgery is considered almost inevitable and a major cause of morbidity. Novel treatments have been proposed, however there is a lack of suitable small animal models for pre-clinical evaluation, mainly du
Externí odkaz:
https://doaj.org/article/f2faee0ff77c433d9666aa2bfa92ff9c
Autor:
Ghais Houtak, Roshan Nepal, George Bouras, Gohar Shaghayegh, Catherine Bennett, John Finnie, Kevin Fenix, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Chronic Rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinus mucosa. Despite being a common health issue, the exact cause of CRS is yet to be understood. However, research suggests thatStaphylococcus aureus, particularly in the bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d50e6dd7b6f47de36a472765013350a8
https://doi.org/10.1101/2023.03.29.534842
https://doi.org/10.1101/2023.03.29.534842
