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Akademický článek

SIGNET: protocol for a multicentre, single-blind prospective, group sequential, randomised controlled trial to evaluate the benefits of a single dose of simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients

Publikováno v: BMJ Open, Vol 14, Iss 9 (2024)

Introduction Successful organ transplantation in patients with end-stage organ failure improves long-term survival, improves quality of life and reduces costs to the NHS. Despite an increase in the number of deceased organ donors over the last decade

Externí odkaz: https://doaj.org/article/a6bc3dca5dab4370ba91dc99d392b13b

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Akademický článek

A Split-Lung Ex Vivo Perfusion Model for Time- and Cost-Effective Evaluation of Therapeutic Interventions to the Human Donor Lung

Autor: Nicholas J. S. Chilvers, Jenny Gilmour, Marnie L. Brown, Lucy Bates, Chong Yun Pang, Henning Pauli, John Dark, Andrew J. Fisher

Publikováno v: Transplant International, Vol 37 (2024)

With the ongoing shortage of donor lungs, ex vivo lung perfusion (EVLP) offers the opportunity for objective assessment and potential therapeutic repair of marginal organs. There is a need for robust research on EVLP interventions to increase the num

Externí odkaz: https://doaj.org/article/ddc6b16e4b6c48f7b7bbefab43a5e39e

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Transplantation of Organs From DCD and DBD Donors Who Died After Ligature Asphyxiation

Autor: Patrick B, Trotter, John, Dark, Andrew J, Fisher, Matthew, Robb, Christopher, Watson, James, Neuberger

Publikováno v: Transplantation. 107:529-539

The United Kingdom transplant registry data demonstrated similar transplant outcomes for recipients of kidneys from donors who died following ligature asphyxiation and those who received organs from donors dying from other causes. The impact that thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8413bdca27d6f14f7f4bd3fc2137bd
https://doi.org/10.1097/tp.0000000000004296

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A cell atlas of the human outflow tract of the heart and its adult derivatives

Autor: Rotem Salmi Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Dark, Simon Bamforth, Nicoletta Bobola

The outflow tract (OFT) of the heart carries blood away from the heart into the great arteries. During embryogenesis the OFT divides to the aorta and pulmonary trunk, which originate from the left and right ventricles, respectively, creating the doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec718b450a2b1d117af3dd483b0a1751
https://doi.org/10.1101/2023.04.05.535627

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Diagnosis and predicted outcomes of patients with cystic fibrosis related liver disease considered for lung transplantation

Autor: Espeed Khoshbin, Stephen Clark, Gerard Meachery, Andrew Fisher, Anthony De Soyza, James Lordan, Arun Nair, John Dark, Mark Hudson

Publikováno v: Clinical Transplantation. 36

There is no gold standard criterion for the diagnosis of cystic fibrosis-related liver disease (CFRLD) and there is uncertainty over its impact on the outcome of lung transplantation.Lung recipients (n = 238) were divided into two groups-CFRLD and no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f9d3d3ed690838c371795c896e158b
https://doi.org/10.1111/ctr.14713

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Akademický článek

An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK

Publikováno v: Health Technology Assessment, Vol 20, Iss 85 (2016)

Background: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. Objective: The objective of the

Externí odkaz: https://doaj.org/article/9ead76bee00f4789973b34b8001e4532

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