Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John, Collington"'
Autor:
Elizabeth Kinchin, Lilian Alcaraz, Aaron Rigby, Haydn Beaton, Matt Soars, Rebecca Denton, Keith Bowers, Ash Bahl, David Donald, John Collington, Cathy MacDonald, Rob Riley, Peter J. H. Webborn, Christopher A. Luckhurst, Brian Springthorpe, Mark Furber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7702-7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting
Autor:
Aaron Rigby, Peter J. H. Webborn, Rob Riley, John Collington, Mark Furber, Brian Springthorpe, Matt Soars, Ash Bahl, Cathy MacDonald, Keith Bowers, Elizabeth Kinchin, Lilian Alcaraz, Rebecca Denton, Haydn Beaton, David Donald, Christopher A. Luckhurst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7707-7710
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Autor:
Mark, Furber, Lilian, Alcaraz, Christopher, Luckhurst, Ash, Bahl, Haydn, Beaton, Keith, Bowers, John, Collington, Rebecca, Denton, David, Donald, Elizabeth, Kinchin, Cathy, MacDonald, Aaron, Rigby, Rob, Riley, Matt, Soars, Brian, Springthorpe, Peter, Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Autor:
Mark Furber, Cladingboel David, Janice Bent, M.J. Robertson, Timothy Jon Luker, Lilian Alcaraz, Michael Mortimore, Moya Caffrey, Martin Braddock, Robert J. Riley, Celine Laurent, Peter J. H. Webborn, Frank Ince, Philip Thorne, Jill Theaker, John Collington, Elizabeth Kinchin, Mandy Lawson, Austen Pimm, Armin Beyerbach, Richard J. Weaver, Keith Bowers, David Donald, Malbinder Fagura, Paul Willis, Nicola Roberts
Publikováno v:
Journal of medicinal chemistry. 50(24)
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 i
Autor:
Mark Furber, Lilian Alcaraz, Janice E. Bent, Armin Beyerbach, Keith Bowers, Martin Braddock, Moya V. Caffrey, David Cladingboel, John Collington, David K. Donald, Malbinder Fagura, Frank Ince, Elizabeth C. Kinchin, Celine Laurent, Mandy Lawson, Timothy J. Luker, Michael M. P. Mortimore, Austen D. Pimm, Robert J. Riley, Nicola Roberts
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 24, p5882-5885, 4p