Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Autor: Filip Liebsch, Luka Kulic, Charlotte Teunissen, Adeola Shobo, Irem Ulku, Vivienne Engelschalt, Mark A. Hancock, Wiesje M. van der Flier, Peter Kunach, Pedro Rosa-Neto, Philip Scheltens, Judes Poirier, Paul Saftig, Randall J. Bateman, John Breitner, Christoph Hock, Gerhard Multhaup

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Aβ34 is generated from degradation of Aβ40 and Aβ42 by β-secretase. Here, the authors show that Aβ34 is a marker for amyloid clearance and is elevated in the CSF of patients that go on to convert from mild cognitive impairment to Alzheimer’s d

Externí odkaz: https://doaj.org/article/b145f3c2811a4f8c9097430d26ff9fe5

A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment

Autor: Angela Tam, Christian Dansereau, AmanPreet Badhwar, Pierre Orban, Sylvie Belleville, Howard Chertkow, Alain Dagher, Alexandru Hanganu, Oury Monchi, Pedro Rosa-Neto, Amir Shmuel, John Breitner, Pierre Bellec

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 1122-1129 (2016)

We present group eight resolutions of brain parcellations for clusters generated from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four indep

Externí odkaz: https://doaj.org/article/0f678fd86b31405e9879f283368d8320

Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity

Autor: Yasser Iturria-Medina, Quadri Adewale, Ahmed F. Khan, Simon Ducharme, Pedro Rosa-Neto, Kieran O’Donnell, Vladislav A. Petyuk, Serge Gauthier, Philip L. De Jager, John Breitner, David A. Bennett

Publikováno v: Science advances. 8(46)

Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data ( N = 1863), we integrated epigenomic,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b2d4fc0129c73a2bf97c5b65412ece
https://pubmed.ncbi.nlm.nih.gov/36399579

Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease

Autor: Sander C.J. Verfaillie, Alexa Pichet Binette, Etienne Vachon-Presseau, Shirin Tabrizi, Mélissa Savard, Pierre Bellec, Rik Ossenkoppele, Philip Scheltens, Wiesje M. van der Flier, John C.S. Breitner, Sylvia Villeneuve, Paul Aisen, Elena Anthal, Melissa Appleby, Gülebru Ayranci, Alan Barkun, Thomas Beaudry, Fatiha Benbouhoud, Veronique Bohbot, Jason Brandt, John Breitner, Leopoldina Carmo, Edouard Carrier Charles, Mallar Chakravarty, Laksanun Cheewakriengkrai, Louis Collins, Blandine Courcot, Doris Couture, Suzanne Craft, Claudio Cuello, Mahsa Dadar, Christian Dansereau, null DasSamir, Dauar-Tedeschi Marina, Doris Dea, Clement Debacker, Rene Desautels, Sylvie Dubuc, Guerda Duclair, Marianne Dufour, Mark Eisenberg, Rana El-Khoury, Pierre Etienne, Alan Evans, Anne-Marie Faubert, Fabiola Ferdinand, Vladimir Fonov, David Fontaine, Josée Frappier, Frenette Joanne, Guylaine Gagne, Serge Gauthier, Valérie Gervais, Renuka Giles, Julie Gonneaud, Renee Gordon, Rick Hoge, Bradley Hyman, Yasser Ituria-Medina, Clifford Jack, Justin Kat, Christina Kazazian, Zaven Khachaturian, David Knopman, Penelope Kostopoulos, Anne Labonte, Marie-Elyse Lafaille-Magnan, Tanya Lee, Jeannie-Marie Leoutsakos, Claude Lepage, Illana Leppert, Cécile Madjar, Laura Mahar, David Maillet, Jean-Robert Maltais, Axel Mathieu, Sulantha Mathotaarachchi, Gerhard Maultaup, Ginette Mayrand, Pierre-François Meyer, Diane Michaud, Justin Miron, Thomas Montine, John Morris, Lisa-Marie Münter, Vasavan Nair, Jamie Near, Holly Newbold-Fox, Pierre Orban, Véronique Page, Tharick Pascoal, Mirela Petkova, Cynthia Picard, Galina Pogossova, Judes Poirier, Jens Pruessner, Natasha Rajah, Pierre Rioux, Pedro Rosa-Neto, Mark Sager, Eunice Farah Saint-Fort, Reisa Sperling, Angela Tam, Christine Tardif, Pierre Tariot, Eduard Teigner, Louise Theroux, Ronald Thomas, Paule-Joanne Toussaint, Jennifer Tremblay-Mercier, Miranda Tuwaig, Isabelle Vallee, Vinod Venugopalan, Sander Verfaillie, Jacob Vogel, Karen Wan, Seqian Wang, Elsa Yu

Publikováno v: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(5), 463-472. Elsevier Inc.
Verfaillie, S, Pichet Binette, A, Vachon-Presseau, E, Tabrizi, S, Savard, M, Bellec, P, Ossenkoppele, R, Scheltens, P, van der Flier, W M, Breitner, J C S, Villeneuve, S, Aisen, P, Anthal, E, Appleby, M, Ayranci, G, Barkun, A, Beaudry, T, Bellec, P, Benbouhoud, F, Bohbot, V, Brandt, J, Breitner, J, Carmo, L, Carrier Charles, E, Chakravarty, M, Cheewakriengkrai, L, Collins, L, Courcot, B, Couture, D, Craft, S, Cuello, C, Dadar, M, Dansereau, C, DasSamir, Marina, D T, Dea, D, Debacker, C, Desautels, R, Dubuc, S, Duclair, G, Dufour, M, Eisenberg, M, El-Khoury, R, Etienne, P, Evans, A, Faubert, A M, Ferdinand, F, Fonov, V, Vogel, J & PREVENT-AD Research Group 2018, ' Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 3, no. 5, pp. 463-472 . https://doi.org/10.1016/j.bpsc.2017.11.012

Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8cda6d05a5aa4e5888d45b2dcc13a2
https://research.vumc.nl/en/publications/3c211a42-1672-429e-b9df-8c647bf22073

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