Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John, Boulos"'
Autor:
Dominik Nelic, Nikolai Chetverikov, Martina Hochmalová, Christina Diaz, Vladimír Doležal, John Boulos, Jan Jakubík, Kirill Martemyanov, Alena Janoušková-Randáková
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Selective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well. The flexible G-protein interface of m
Externí odkaz:
https://doaj.org/article/03ce4b98fb3949499a075156508c3010
Autor:
Alena Randáková, Dominik Nelic, Martina Hochmalová, Pavel Zimčík, Mutale Jane Mulenga, John Boulos, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10089 (2021)
A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream sig
Externí odkaz:
https://doaj.org/article/02b106b875504802b6a348b058fbf887
Autor:
Jan Jakubík, Dominik Nelic, Alena Randáková, Esam E. El-Fakahany, John Boulos, Vladimír Doležal
Publikováno v:
Journal of Chemical Information and Modeling. 60:2325-2338
Binding of muscarinic ligands, both antagonists and agonists, and their effects on the conformation of the M2 acetylcholine receptor were modeled in silico and compared to experimental data. After docking of antagonists to the M2 receptor in an inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d938cc8e2e91a58c99f604729a149e
https://doi.org/10.1021/acs.jcim.0c00041
https://doi.org/10.1021/acs.jcim.0c00041
Autor:
StacyA. Voils, Lindsey M. Childs-Kean, Michelle Z. Farland, Kathryn J. Smith, John Boulos, Christopher T. Campbell, Teresa M. Cavanaugh, Christina E. DeRemer, Katerina Lambrinos, Stacy L. Miller, Barbara Santevecchi, Bethany R. Shoulders, Carinda Feild, John Allen
Publikováno v:
Currents in pharmacy teachinglearning. 14(3)
The purpose of this study was to compare student and faculty perceptions of strength of residency candidacy and to identify student preferences and perceptions that influence the process of being selected by a residency program beyond standard applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fc3ba59437458446c609948c184834
https://pubmed.ncbi.nlm.nih.gov/35307089
https://pubmed.ncbi.nlm.nih.gov/35307089
Autor:
Alena, Randáková, Dominik, Nelic, Vladimír, Doležal, Esam E, El-Fakahany, John, Boulos, Jan, Jakubík
Publikováno v:
Journal of chemical information and modeling. 60(4)
Binding of muscarinic ligands, both antagonists and agonists, and their effects on the conformation of the M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::335b982df86269b5d3a358b393eb8466
https://pubmed.ncbi.nlm.nih.gov/32130001
https://pubmed.ncbi.nlm.nih.gov/32130001
Autor:
Dominik Nelic, Dana Ungerová, Qiwen Su, John Boulos, Vladimír Doležal, Peter Nwokoye, Esam E. El-Fakahany, Alena Randáková, Jan Jakubík
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: More than 30% of currently marketed medications act via GPCRs. Thus, GPCRs represent one of the most important pharmacotherapeutic targets. In contrast to traditional agonists activating multiple signalling pathways, agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7de007096e07857a3060b4e3e6c45b6
https://europepmc.org/articles/PMC7161557/
https://europepmc.org/articles/PMC7161557/
Publikováno v:
British Journal of Pharmacology. 175:1731-1743
Background & Purpose The aim of this study was to develop potent and long-acting antagonists of muscarinic acetylcholine receptors. 4-hexyloxy and 4-butyloxy derivatives of 1-[2-(4-oxidobenzoyloxy)ethyl]-1,2,3,6-tetrahydropyridin-1-ium were synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076cae4d83b88d55d5791f42920075d6
https://doi.org/10.1111/bph.14187
https://doi.org/10.1111/bph.14187
Autor:
Pavel Zimčík, Dominik Nelic, Mutale Jane Mulenga, John Boulos, Martina Hochmalová, Alena Randáková, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10089, p 10089 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffafb411d5a5603f9d37410b62f21e9d
https://doi.org/10.3390/ijms221810089
https://doi.org/10.3390/ijms221810089
Publikováno v:
Chemical Biology & Drug Design. 91:93-104
Muscarinic receptors are known to play important biological roles and are drug targets for several human diseases. In a pilot study, novel muscarinic antagonists were synthesized and used as chemical probes to obtain additional information of the mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b579d475c0acbbac04c6b9a5286c50
https://doi.org/10.1111/cbdd.13059
https://doi.org/10.1111/cbdd.13059