Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits

Autor: Monshupanee, Tanakarn, Johansen, Shanna K, Dahlberg, Albert E, Douthwaite, Stephen Roger

Publikováno v: Monshupanee, T, Johansen, S K, Dahlberg, A E & Douthwaite, S R 2012, ' Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits ', Molecular Microbiology, vol. 85, no. 6, pp. 1194-203 . https://doi.org/10.1111/j.1365-2958.2012.08168.x

The binding site of the cyclic peptide antibiotics capreomycin and viomycin is located on the ribosomal subunit interface close to nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. In Mycobacterium tuberculosis, the 2'-hydroxyls of both nucleotide

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