Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Johannes Witt"'
Autor:
Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey J. Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt, David Heckmann
Publikováno v:
Environment International, Vol 169, Iss , Pp 107547- (2022)
Physiologically-based kinetic (PBK) models are effective tools for designing toxicological studies and conducting extrapolations to inform hazard characterization in risk assessment by filling data gaps and defining safe levels of chemicals. In the p
Externí odkaz:
https://doaj.org/article/538906f5c3854aa58c32c8940c07db7d
Autor:
Colin G. Scanes, Johannes Witt, Markus Ebeling, Stephan Schaller, Vanessa Baier, Audrey J. Bone, Thomas G. Preuss, David Heckmann
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Physiologically based kinetic (PBK) models facilitate chemical risk assessment by predicting in vivo exposure while reducing the need for animal testing. PBK models for mammals have seen significant progress, which has yet to be achieved for avian sy
Externí odkaz:
https://doaj.org/article/09094be1b329470ca8bc8aaf1821c6a9
Autor:
Colin G. Scanes, Johannes Witt, Markus Ebeling, Stephan Schaller, Vanessa Baier, Audrey J. Bone, Thomas G. Preuss, David Heckmann
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Physiologically based kinetic (PBK) models are a promising tool for xenobiotic environmental risk assessment that could reduce animal testing by predicting in vivo exposure. PBK models for birds could further our understanding of species-specific sen
Externí odkaz:
https://doaj.org/article/bdb0a64ecaea48b2bd5331d5090c675b
Autor:
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resul
Externí odkaz:
https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a13
Autor:
Elena Busch, Aysel Ahadova, Kosima Kosmalla, Lena Bohaumilitzky, Pauline L. Pfuderer, Alexej Ballhausen, Johannes Witt, Jan-Niklas Wittemann, Hendrik Bläker, Elke Holinski-Feder, Dirk Jäger, Magnus von Knebel Doeberitz, Georg Martin Haag, Matthias Kloor
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Immune checkpoint blockade (ICB) shows remarkable clinical effects in patients with metastatic microsatellite-unstable (MSI) cancer. However, markers identifying potential non-responders are missing. We examined the prevalence of Beta-2-microglobulin
Externí odkaz:
https://doaj.org/article/af5a317a8a3c4eed9d3bbbffc9e6c45c
Autor:
Aysel Ahadova, Pauline Luise Pfuderer, Maarit Ahtiainen, Alexej Ballhausen, Lena Bohaumilitzky, Svenja Kösegi, Nico Müller, Yee Lin Tang, Kosima Kosmalla, Johannes Witt, Volker Endris, Albrecht Stenzinger, Magnus von Knebel Doeberitz, Hendrik Bläker, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Toni T. Seppälä, Matthias Kloor
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 11, p 2458 (2021)
Regular colonoscopy even with short intervals does not prevent all colorectal cancers (CRC) in Lynch syndrome (LS). In the present study, we asked whether cancers detected under regular colonoscopy surveillance (incident cancers) are phenotypically d
Externí odkaz:
https://doaj.org/article/28e2038062bd4e5191fa8dac80dc67fc
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003528 (2014)
The transcription factor nuclear factor kappa-B (NFκB) is a key regulator of pro-inflammatory and pro-proliferative processes. Accordingly, uncontrolled NFκB activity may contribute to the development of severe diseases when the regulatory system i
Externí odkaz:
https://doaj.org/article/dc042349a89c4c7887cbf6fdb2b89a8b
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40274 (2012)
Activation of nuclear factor κB (NF-κB) by interleukin-1β (IL-1) usually results in an anti-apoptotic activity that is rapidly terminated by a negative feedback loop involving NF-κB dependent resynthesis of its own inhibitor IκBα. However, apop
Externí odkaz:
https://doaj.org/article/f5eacdb6710f431593a2325859fd99b3
Autor:
Aysel Ahadova, Johannes Witt, Saskia Haupt, Richard Gallon, Robert Hüneburg, Jacob Nattermann, Sanne ten Broeke, Lena Bohaumilitzky, Alejandro Hernandez‐Sanchez, Mauro Santibanez‐Koref, Michael S. Jackson, Maarit Ahtiainen, Kirsi Pylvänäinen, Katarina Andini, Vince Kornel Grolmusz, Gabriela Möslein, Mev Dominguez‐Valentin, Pål Møller, Daniel Fürst, Rolf Sijmons, Gillian M. Borthwick, John Burn, Jukka‐Pekka Mecklin, Vincent Heuveline, Magnus von Knebel Doeberitz, Toni Seppälä, Matthias Kloor
Publikováno v:
International Journal of Cancer. 152:2024-2031
Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more prec
Publikováno v:
Environmental Toxicology and Chemistry.