Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Johannes Wilbertz"'
Autor:
Maria Bloksgaard, Signe Bek, Ann-Britt Marcher, Ditte Neess, Jonathan Brewer, Hans Kristian Hannibal-Bach, Torben Helledie, Christina Fenger, Marianne Due, Zane Berzina, Reinhard Neubert, John Chemnitz, Bente Finsen, Anders Clemmensen, Johannes Wilbertz, Henrik Saxtorph, Jens Knudsen, Luis Bagatolli, Susanne Mandrup
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2162-2174 (2012)
The acyl-CoA binding protein (ACBP) is a 10 kDa intracellular protein expressed in all eukaryotic species. Mice with targeted disruption of Acbp (ACBP−/− mice) are viable and fertile but present a visible skin and fur phenotype characterized by g
Externí odkaz:
https://doaj.org/article/95428a8e2fbf49189b0f5e13fbb55ce1
Autor:
Anton Razuvaev, Vincent Fontaine, Charlotta Hjerpe, Xinghua Zhou, Johannes Wilbertz, Dick Wågsäter, Per Eriksson, Jesper Swedenborg, Alexandra Bäcklund, Emina Vorkapic, Anders Hamsten, Kenneth Caidahl, Mikko I. Mäyränpää, Anders Franco-Cereceda, Daniel X. Johansson
Publikováno v:
International Journal of Molecular Medicine; Vol
Remodeling of extracellular matrix (ECM) plays an important role in both atherosclerosis and aneurysm disease. Serine protease inhibitor A3 (serpinA3) is an inhibitor of several proteases such as elastase, cathepsin G and chymase derived from mast ce
Autor:
Lorenz Poellinger, Kian Leong Lee, Katarina Holmborn, Filip Farnebo, Johannes Wilbertz, Fredrik Lanner, Janet Rossant, Marcus Sohl, Henry Yang
Publikováno v:
Stem Cells. 28:191-200
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous leukemia inhibitory factor and BMP4 perpetuate a pluripotent state, less is known about the factors initiating differentiation. We show t
Autor:
Peter Teismann, Andreas R. Luft, Johannes Wilbertz, Kristina Fischer, Olaf Riess, Antje Bornemann, Carsten Calaminus, Jiirgen Tomiuk, Nicolas Casadei, Thomas Franck, Silke Nuber, Rejko Krüger, Sittinan Chanarat, Bernd J. Pichler, Ulrike Schumann, Jörg B. Schulz, Hartwig Wolburg
Publikováno v:
neurogenetics. 11:107-120
Synphilin-1 has been identified as an interacting protein of alpha-synuclein, Parkin, and LRRK2, proteins which are mutated in familial forms of Parkinson’s disease (PD). Subsequently, synphilin-1 has also been shown to be an intrinsic component of
Autor:
Johannes Wilbertz, Mügen Terzioglu, Fredrik H. Sterky, Nils-Göran Larsson, Lene Sörensen, Lars Olson, Dagmar Galter, Eric Dufour
Publikováno v:
Human Molecular Genetics
Heteroplasmic mitochondrial DNA (mtDNA) mutations (mutations present only in a subset of cellular mtDNA copies) arise de novo during the normal ageing process or may be maternally inherited in pedigrees with mitochondrial disease syndromes. A pathoge
Autor:
Annalena Moliner, Abdeljabbar El Manira, Ernest Arenas, Sophie Halliez, Jens Hjerling-Leffler, Patrick Charnay, Carlos F. Ibáñez, Gonçalo Castelo-Branco, Vitezslav Bryja, Hiroshi Nishimaru, Patrik Ernfors, Johannes Wilbertz, Evanthia Nanou, T. Kalle Lundgren, Ester Pozas, Martin Koltzenburg, Michael Andäng
Publikováno v:
Nature. 451:460-464
Stem cell self-renewal implies proliferation under continued maintenance of multipotency. Small changes in numbers of stem cells may lead to large differences in differentiated cell numbers, resulting in significant physiological consequences. Prolif
Autor:
Marlies Knipper, Thorsten Schmidt, Franco Laccone, Hartwig Wolburg, Olaf Riess, Ulrike Bichelmeier, Johannes Wilbertz, Jana Boy, Lukas Rüttiger, Werner J. Schmidt, Karina Häbig, Sven Poths, Jeannette Hübener, Michael Bonin
Publikováno v:
The Journal of Neuroscience. 27:7418-7428
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder caused by the expansion of a CAG repeat in theMJD1gene resulting in an expanded polyglutamine repeat in the ataxin-3 protein. To study the course of
Publikováno v:
Developmental Biology. 289:384-394
More than any other species, humans have difficulty reproducing. As recent studies show that human infertility is ever increasing, much efforts are needed towards the understanding of our low fecundity. While aneuploidy is the leading cause of sponta
Autor:
Lennart Philipson, Stephen Malin, Johannes Wilbertz, Kensaku Okamoto, Lorenz Poellinger, Sven Pettersson, Tiziano Tallone, Annika Samuelsson, Mitsue Miyahara
Publikováno v:
Proceedings of the National Academy of Sciences. 98:7910-7915
The cellular attachment receptor for adenovirus (Ad), Coxsackie adenovirus receptor (CAR), required for delivery of Ad into primary cells, is not present on all cell types, thus restricting Ad-gene delivery systems. To circumvent this constrain, a tr
Publikováno v:
Molecular Endocrinology. 15:172-183
To study further the role of gonadotropins in reproductive functions, we generated mice with LH receptor (LHR) knockout (LuRKO) by inactivating, through homologous recombination, exon 11 on the LHR gene. LuRKO males and females were born phenotypical