Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Johannes Wagener"'
Autor:
Hesham Elsaman, Evgeny Golubtsov, Sean Brazil, Natanya Ng, Isabel Klugherz, Ronny Martin, Karl Dichtl, Christoph Müller, Johannes Wagener
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Azole antifungals inhibit the sterol C14-demethylase (CYP51/Erg11) of the ergosterol biosynthesis pathway. Here we show that the azole-induced synthesis of fungicidal cell wall carbohydrate patches in the pathogenic mold Aspergillus fumigatu
Externí odkaz:
https://doaj.org/article/c262d3c2fb6c430b9997fc04d609248a
Autor:
Karl Dichtl, Andreas Osterman, Johannes Forster, Lena Jakob, Sebastian Suerbaum, Michael J. Flaig, Sören Schubert, Johannes Wagener
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract With an incidence of more than > 1,000,000/day, sexually transmitted diseases remain a major challenge for health care systems worldwide. To reduce disease burden, complications, and spread, rapid diagnosis permitting early therapy is pivota
Externí odkaz:
https://doaj.org/article/7039c6dc5c284fbf840d385c20a371ed
Publikováno v:
Journal of Fungi, Vol 9, Iss 11, p 1074 (2023)
The mitochondrial translocase Bcs1 is required for the correct assembly of complex III of the mitochondrial respiratory chain. Because of its importance, Bcs1 was recently proposed as a target for antifungal agents. The function of this AAA (ATPase A
Externí odkaz:
https://doaj.org/article/ac291a05da22499fafd6505c2ace4861
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Inducible promoters are indispensable elements when considering the possibility to modulate gene expression on demand. Desirable traits of conditional expression systems include their capacity for tight downregulation, high overexpression, a
Externí odkaz:
https://doaj.org/article/6c92b7cd97134a1e8ad129e1a6336104
Autor:
Maximilian Liebl, Ludwig Huber, Hesham Elsaman, Petra Merschak, Johannes Wagener, Fabio Gsaller, Christoph Müller
Publikováno v:
Journal of Fungi, Vol 9, Iss 7, p 768 (2023)
The ergosterol pathway is a promising target for the development of new antifungals since its enzymes are essential for fungal cell growth. Appropriate screening assays are therefore needed that allow the identification of potential inhibitors. We de
Externí odkaz:
https://doaj.org/article/b3ef99aaec4d4227b389236d65b6aab3
Autor:
Özlem Koc, Harald H. Kessler, Martin Hoenigl, Johannes Wagener, Sebastian Suerbaum, Sören Schubert, Karl Dichtl
Publikováno v:
Journal of Fungi, Vol 8, Iss 9, p 972 (2022)
Bloodstream infections caused by Candida yeasts (candidemia) are associated with high morbidity and mortality. Diagnosis remains challenging, with the current gold standard—isolation from blood culture (BC)—being limited by low sensitivity and lo
Externí odkaz:
https://doaj.org/article/36b243fde3844ff9854a763b8a971d68
Autor:
Victor Brantl, Jana M. Boysen, Annie Yap, Evgeny Golubtsov, Dominik Ruf, Thorsten Heinekamp, Maria Straßburger, Karl Dichtl, Hubertus Haas, Falk Hillmann, Johannes Wagener
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Aspergillus fumigatus is an important fungal pathogen that causes allergic reactions but also life-threatening infections. One of the most abundant A. fumigatus proteins is Asp f3. This peroxiredoxin is a major fungal allergen and known for
Externí odkaz:
https://doaj.org/article/6522a73eeb674cb7804e17e5e00d975e
Autor:
Marion Steger, Marta Bermejo-Jambrina, Teodor Yordanov, Johannes Wagener, Axel A Brakhage, Verena Pittl, Lukas A Huber, Hubertus Haas, Cornelia Lass-Flörl, Wilfried Posch, Doris Wilflingseder
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 957-969 (2019)
Complement system and dendritic cells (DCs) form – beside neutrophils and macrophages – the first line of defense to combat fungal infections. Therefore, we here studied interactions of these first immune elements with Aspergillus fumigatus lacki
Externí odkaz:
https://doaj.org/article/c3488627edc64d14bec1b57d05124673
Publikováno v:
Infection. 51:769-774
Purpose Invasive aspergillosis is a major threat to immunocompromised individuals. Galactomannan (GM) is used as a biomarker for invasive aspergillosis. Investigations recommended in current guidelines include GM testing of bronchoalveolar lavage (BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038d014dc7608f258f0d1ee747286e3a
https://doi.org/10.1007/s15010-023-01985-1
https://doi.org/10.1007/s15010-023-01985-1
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Azole resistance of the fungal pathogen Aspergillus fumigatus is an emerging problem. To identify novel mechanisms that could mediate azole resistance in A. fumigatus, we analyzed the transcriptome of a mitochondrial fission/fusion mutant that exhibi
Externí odkaz:
https://doaj.org/article/cdb6488f55154a7ba1a4bccd52c5b250