High-quality, genome-wide SNP genotypic data for pedigreed germplasm of the diploid outbreeding species apple, peach, and sweet cherry through a common workflow.

Autor: Stijn Vanderzande, Nicholas P Howard, Lichun Cai, Cassia Da Silva Linge, Laima Antanaviciute, Marco C A M Bink, Johannes W Kruisselbrink, Nahla Bassil, Ksenija Gasic, Amy Iezzoni, Eric Van de Weg, Cameron Peace

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0210928 (2019)

High-quality genotypic data is a requirement for many genetic analyses. For any crop, errors in genotype calls, phasing of markers, linkage maps, pedigree records, and unnoticed variation in ploidy levels can lead to spurious marker-locus-trait assoc

Externí odkaz: https://doaj.org/article/2c5af91ffcef44a1979ee03b8c9562dd

Potential impact of prioritisation methods on the outcome of cumulative exposure assessments of pesticides

Autor: Johannes W. Kruisselbrink, H. van der Voet, R.C. Sprong, Matthijs Sam, J.D. van Klaveren, M van Lenthe, G. van Donkersgoed, W.J. de Boer, J.D. te Biesebeek

Publikováno v: EFSA Supporting Publications, 18(4)
EFSA Supporting Publications 18 (2021) 4

This report describes the potential impact of a prioritisation method on the outcome of cumulative exposure assessments of pesticides. The method aims to reduce the laborious task of the establishment of cumulative assessment groups (CRAs). The prior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcad2f36563cb0ef9e9df0fc54d8842
https://research.wur.nl/en/publications/potential-impact-of-prioritisation-methods-on-the-outcome-of-cumu

A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals

Autor: Waldo J. de Boer, Johannes W. Kruisselbrink, Vikas Kumar, Céline Brochot, Emiel Rorije, Hilko van der Voet, Cleo Tebby, Georges de Sousa, Moosa Faniband, Angelo Moretto, Frédéric Y. Bois

Publikováno v: Food and Chemical Toxicology
Food and Chemical Toxicology, 2020, 142, ⟨10.1016/j.fct.2020.111440⟩
Food and Chemical Toxicology 142 (2020)
Food and Chemical Toxicology, 142
Food and Chemical Toxicology, Elsevier, 2020, 142, ⟨10.1016/j.fct.2020.111440⟩

International audience; Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic PBTK m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bec9ff2c0863eeca291af044a5149c
http://hdl.handle.net/10029/623888

The MCRA toolbox of models and data to support chemical mixture risk assessment

Autor: Johannes W. Kruisselbrink, Cleo Tebby, Jacob D. van Klaveren, Marco S. van Lenthe, Alfonso Lampen, Céline Brochot, Marc C. Kennedy, Emiel Rorije, Amélie Crépet, Anna Beronius, Hilko van der Voet, Johanna Zilliacus, Waldo J. de Boer, J.J.B. van den Heuvel, Claudia Luckert, Corinne Sprong

Publikováno v: Food and Chemical Toxicology, 138
Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology 138 (2020)

International audience; A model and data toolbox is presented to assess risks from combined exposure to multiple chemicals using probabilistic methods. The Monte Carlo Risk Assessment (MCRA) toolbox, also known as the EuroMix toolbox, has more than 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b129c002c620caf3cc15fc5e8d6d5fcb
https://pubmed.ncbi.nlm.nih.gov/32058012

Modelling aggregate exposure to pesticides from dietary and crop spray sources in UK residents

Autor: David Garthwaite, Waldo J. de Boer, Marc C. Kennedy, Johannes W. Kruisselbrink

Publikováno v: Environmental Science and Pollution Research 26 (2019) 10
Environmental Science and Pollution Research
Environmental Science and Pollution Research, 26(10), 9892-9907

Human exposure to pesticide mixtures can occur from the diet and other sources. Realistic exposure and risk assessments should include multiple sources and compounds and include the relative hazards of the different compounds. The EU-funded Euromix p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220ec6c3ea86ecd0b7073495847147cd
https://research.wur.nl/en/publications/modelling-aggregate-exposure-to-pesticides-from-dietary-and-crop-