A rat model for muscle regeneration in the soft palate.

Autor: Paola L Carvajal Monroy, Sander Grefte, Anne M Kuijpers-Jagtman, Maria P A C Helmich, Dietmar J O Ulrich, Johannes W Von den Hoff, Frank A D T G Wagener

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59193 (2013)

BACKGROUND: Children with a cleft in the soft palate have difficulties with speech, swallowing, and sucking. Despite successful surgical repositioning of the muscles, optimal function is often not achieved. Scar formation and defective regeneration m

Externí odkaz: https://doaj.org/article/c2822e04b6034c45a56ba032214e4dba

Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing

Autor: Zhihao Wang, Rob Knight, Phil Stephens, E. M. Ongkosuwito, Frank A. D. T. G. Wagener, Johannes W. Von den Hoff

Publikováno v: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneratio

Externí odkaz: https://doaj.org/article/64b3a15a28154f23a91d5f72e1b5cc8a

Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae

Autor: Liesbeth Gebuijs, Frank A. Wagener, Jan Zethof, Carine E. Carels, Johannes W. Von den Hoff, Juriaan R. Metz

Publikováno v: PeerJ, Vol 10, p e14338 (2022)

Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone develop

Externí odkaz: https://doaj.org/article/400f02b5725e4e5aa43075316e757f21

Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

Autor: S. T. Raterman, J. R. Metz, Frank A. D. T. G. Wagener, Johannes W. Von den Hoff

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

The zebrafish is an appealing model organism for investigating the genetic (G) and environmental (E) factors, as well as their interactions (GxE), which contribute to craniofacial malformations. Here, we review zebrafish studies on environmental fact

Externí odkaz: https://doaj.org/article/e7893fa2d8d74166a508601d335326cc

Excess vitamin a might contribute to submucous clefting by inhibiting WNT ‐mediated bone formation

Autor: Charlotte Lucienne Jacqueline Maria Krutzen, Laury A. Roa, Marjon Bloemen, Johannes W. Von den Hoff

Publikováno v: Orthodontics and Craniofacial Research, 26, 1, pp. 132-139
Orthodontics & Craniofacial Research, 26(1), 132-139. Wiley-Blackwell
Orthodontics and Craniofacial Research, 26, 132-139

Contains fulltext : 291236.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Cleft lip and/or palate (CLP) is a common craniofacial birth defect caused by genetic as well as environmental factors. The phenotypic spectrum of CLP also includes sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d13e4bd8a3e560f1c1a3b6176dcf80
https://doi.org/10.1111/ocr.12594