Výsledky vyhledávání - "Johannes U. Ammann"

Butyrophilin Btn2a2 Inhibits TCR Activation and Phosphatidylinositol 3-Kinase/Akt Pathway Signaling and Induces Foxp3 Expression in T Lymphocytes

Autor: Johannes U. Ammann, John Trowsdale, Anne Cooke

Publikováno v: The Journal of Immunology. 190:5030-5036

The butyrophilin-related protein Btn2a2 was upregulated on murine APC including CD19+ B cells, CD11b+F4/80+ peritoneal macrophages, and CD11c+ bone marrow–derived dendritic cells after activation with LPS or Pam3CysK4, suggesting a role in modulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::667df31c8ddc5b4efc61c91bc9f111a6
https://doi.org/10.4049/jimmunol.1203325

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BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell Activation

Autor: John Trowsdale, Brittany R. Knezevic, Isobel A. Smith, Donald B. Palmer, Ian H. Mather, David A. Rhodes, Danielle Aw, Johannes U. Ammann

Publikováno v: The Journal of Immunology. 184:3514-3525

Butyrophilin (BTN) genes encode a set of related proteins. Studies in mice have shown that one of these, BTN1A1, is required for milk lipid secretion in lactation, whereas butyrophilin-like 2 is a coinhibitor of T cell activation. To understand these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c5449ab92a1f91f86fe505b2f7855c
https://doi.org/10.4049/jimmunol.0900416

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Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-κB inhibition

Autor: Simone Fulda, Christian Haag, Hubert Kasperczyk, Klaus-Michael Debatin, Johannes U. Ammann

Publikováno v: International Journal of Cancer. 124:1301-1311

The transcription factor nuclear factor-kappaB (NF-kappaB) plays a central role in stress-induced transcriptional activation and has been implicated in chemoresistance of cancers. In the present study, we investigated the role of NF-kappaB in inducib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6eb9d01f33337aed61f99fc124e443c
https://doi.org/10.1002/ijc.24068

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Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins

Autor: Michael R. Dyson, Johannes U. Ammann, John Trowsdale, James C. Kaufman, Martin Jahnke

Publikováno v: European Journal of Immunology. 42:1354-1356

Dimeric IgG1 Fc tail-based fusion proteins are popular reagents in immunology. They are used for receptor activation, by mimicking ligands, and for meas-uring binding of proteins to receptors on cells. Using IgG fusion proteins, only those interactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc9f6658804cb15a30639771ec54ef60
https://doi.org/10.1002/eji.201142151

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Development and Use of IgM/J‐Chain Fusion Proteins for Characterization of Immunoglobulin Superfamily Ligand‐Receptor Interactions

Autor: Johannes U. Ammann, John Trowsdale

Publikováno v: Current Protocols in Protein Science

Discovery of binding partners for immunoglobulin molecules expressed by cells of the immune system is an important topic of current research. However, many ligand-receptor interactions are of low affinity, and hence detection is refractory to most es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6404d993bd1ca1598cfe3d9119177587
https://doi.org/10.1002/0471140864.ps1924s75

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Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins

Autor: Johannes U, Ammann, Martin, Jahnke, Michael R, Dyson, Jim, Kaufman, John, Trowsdale

Publikováno v: European Journal of Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c69f3fb99f6f322019bad846d9f3fb23
https://pubmed.ncbi.nlm.nih.gov/22539303

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