Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Autor: Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter, Ian F Hermans

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural

Externí odkaz: https://doaj.org/article/423fa268183140eca4c64e8a2ff85aed

Skin-infiltrating T cells display distinct inflammatory signatures in lichen planus, bullous pemphigoid and pemphigus vulgaris

Autor: Jona Schinner, Tomas Cunha, Johannes U. Mayer, Stefan Hörster, Peter Kind, Dario Didona, Corinna Keber, Michael Hertl, Thomas Worzfeld, Hazem A. Juratli

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionWe here thought to dissect the inflammatory signature in lesions of three skin disorders, which show a common adaptive immune response against autoantigens of the skin but are characterized by diverging clinical phenotypes. Pemphigus vulg

Externí odkaz: https://doaj.org/article/37d5ee7a440a444bbade011147d5dd2b

MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Autor: Karmella Naidoo, Aurélie Gestin, Yanyan Li, Ian F. Hermans, Katie Gell, Gavin F. Painter, Andrew J. Marshall, Elizabeth A. Jacobsen, David O’Sullivan, Alfonso J Schmidt, Olivier Gasser, Alissa Cait, Christophe Pellefigues, Katherine Woods, Regan J. Anderson, Johannes U Mayer, Kef K Prasit

Background: Mucosal-associated invariant T (MAIT) cells are unconventional T cells which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT cells have been shown to reside in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b876d355c85ce84c5a8acc008659bfba
https://doi.org/10.1111/all.14994

Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization

Autor: Kirsty A. Wakelin, Greta R Webb, Frank Brombacher, Lisa M Connor, Alan Sher, Sventja von Daake, David Gallego-Ortega, Luis Munoz-Erazo, Jianping Yang, Franca Ronchese, Sally Chappell, Charles R. Mackay, Johannes U Mayer, Dragana Jankovic, Matthew R. Hepworth, Graham Le Gros, David Eccles, Shiau-Choot Tang, Jodie Chandler, Olivier Lamiable, Kerry L Hilligan, Samuel I Old, Evelyn J Hyde, Rita G. Domingues, Roxane Tussiwand

Publikováno v: Nature Immunology. 22:1538-1550

The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a8f10747be6403aa118da0f9d7bdd1d
https://doi.org/10.1038/s41590-021-01067-0

Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology

Autor: Melanie Albrecht, Bianca Schaub, Stefanie Gilles, Jörg Köhl, Sabine Altrichter, David Voehringer, Edzard Spillner, Marc Ehlers, Friederike Jönsson, Karin Loser, Johannes U Mayer, Lennart M Rösner, Christian Möbs, Guido Heine, Wolfgang Pfützner

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2022, 52 (6), pp.851-855. ⟨10.1002/eji.202270065⟩
Albrecht, M, Schaub, B, Gilles, S, Köhl, J, Altrichter, S, Voehringer, D, Spillner, E, Ehlers, M, Jönnson, F, Loser, K, Mayer, J U, Rösner, L M, Möbs, C, Heine, G & Pfützner, W 2022, ' Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology ', European Journal of Immunology .
Albrecht, M, Schaub, B, Gilles, S, Köhl, J, Altrichter, S, Voehringer, D, Spillner, E, Ehlers, M, Jönsson, F, Loser, K, Mayer, J U, Rösner, L M, Möbs, C, Heine, G & Pfützner, W 2022, ' Current research and unmet needs in allergy and immunology in Germany : report presented by the DGfI and DGAKI task force Allergy & Immunology ', European Journal of Immunology, vol. 52, no. 6, pp. 851-855 . https://doi.org/10.1002/eji.202270065

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d71eaaadb67be60356acb12437d61d6
https://hal-pasteur.archives-ouvertes.fr/pasteur-04145619