Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Johannes T.-H. Yeh"'
Autor:
Min Yao, Jonathan Preall, Johannes T.-H. Yeh, Darryl Pappin, Paolo Cifani, Yixin Zhao, Sophia Shen, Philip Moresco, Brian He, Hardik Patel, Amber N. Habowski, Daniel A. King, Kara Raphael, Arvind Rishi, Divyesh Sejpal, Matthew J. Weiss, David Tuveson, Douglas T. Fearon
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Intratumoral B cell responses are associated with more favorable clinical outcomes in human pancreatic ductal adenocarcinoma (PDAC). However, the antigens driving these B cell responses are largely unknown. We sought to discover these antigens by usi
Externí odkaz:
https://doaj.org/article/ecd02e7631a843fcb9f7b9f96b213e9d
Publikováno v:
Genes & Development.
Targeted protein degradation (TPD) has risen as a promising therapeutic modality. Leveraging the catalytic nature of the ubiquitin–proteasome enzymatic machinery, TPD exhibits higher potency to eliminate disease-causing target proteins such as onco
Autor:
Jason S. Lewis, Michael Goggins, Ela Elyada, Kenneth H. Yu, Ralph H. Hruban, Libia Garcia, David A. Tuveson, Hardik Patel, Darryl J. Pappin, Joseph R. Merrill, Tobiloba E. Oni, Giulia Biffi, Johannes T.-H. Yeh, Scott K. Lyons, Carmelita Bautista, Keith Rivera, Dennis Plenker, Maria Samaritano, Jeroen A.C.M. Goos, Koji Miyabayashi
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, as 90% of patients do not survive beyond five years from diagnosis. This dismal prognosis is largely due to the advanced stage of the disease at diagnosis, which precludes potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67dd91b4d58e7d7133cf23bf1ba16f7c
https://doi.org/10.1101/2020.09.10.292193
https://doi.org/10.1101/2020.09.10.292193
Autor:
Zilma P. Muneeswaran, Monika Raj, Tiauna S. Howard, Ogonna Nwajiobi, Johannes T.-H. Yeh, Ryan D. Cohen, Neelam N. Lahankar, Yonnette E. Sim
Publikováno v:
Org Lett
A site-specific bioconjugation was developed based on direct aldol coupling using amino acid-derived organocatalysts. The functionalization exhibits fast kinetics and occurs under mild, biocompatible conditions (viz., aqueous media, moderate temperat
Autor:
Chun Gwon Park, Johannes T.-H. Yeh, David Ng, Lloyd C. Trotman, Mario A. Shields, Jean Albrengues, Ellese M. Carmona, Dale Uyeminami, Laura Maiorino, Mikala Egeblad, Phyllis A. Gimotty, Douglas T. Fearon, Priya Upadhyay, Victoria Küttner, Carmelita Bautista, Michael S. Goldberg, Kent E. Pinkerton, Emilis Bružas, Arnaud Pommier, Scott K. Lyons, Alexandra Ambrico, Morgan E. Poindexter, Kenneth Chang
Publikováno v:
Science (New York, N.Y.), vol 361, iss 6409
INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a different tissue, rather than from their original tumor. After successful treatment of the original tumor, cancer cells that have disseminated to other sites can under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4540c6b7f30194a0a75ecc7747ba0dc4
https://escholarship.org/uc/item/07z534z0
https://escholarship.org/uc/item/07z534z0
Autor:
Gerard Hilinski, Young-Woo Kim, Gregory L. Verdine, Tom N. Grossmann, Raymond E. Moellering, Qian Chu, Johannes T. H. Yeh
Publikováno v:
Chu, Q, Moellering, R E, Hilinski, G J, Kim, Y-W, Grossmann, T N, Yeh, J T-H & Verdine, G L 2015, ' Towards understanding cell penetration by stapled peptides ', MedChemComm, vol. 6, no. 1, pp. 111-119 . https://doi.org/10.1039/c4md00131a
MedChemComm, 6(1), 111-119. Royal Society of Chemistry
MedChemComm, 6(1), 111-119. Royal Society of Chemistry
Hydrocarbon-stapled α-helical peptides are a new class of targeting molecules capable of penetrating cells and engaging intracellular targets formerly considered intractable. This technology has been applied to the development of cell-permeable liga
eUnaG: a new ligand-inducible fluorescent reporter to detect drug transporter activity in live cells
Publikováno v:
Scientific Reports
The absorption, distribution, metabolism and excretion (ADME) of metabolites and toxic organic solutes are orchestrated by the ATP-binding cassette (ABC) transporters and the organic solute carrier family (SLC) proteins. A large number of ABC and SLC
Publikováno v:
Angewandte Chemie. 126:4425-4429
Molekulare Template binden spezifisch Reaktanten und erhohen somit deren effektive Konzentration, was zur Beschleunigung von chemischen Reaktionen fuhren kann. Dieses Konzept wurde bereits erfolgreich auf einige Fragestellungen vor allem aus dem Bere
Publikováno v:
Brauckhoff, N, Hahne, G, Yeh, J T-H & Grossmann, T N 2014, ' Protein-Templated Peptide Ligation** ', Angewandte Chemie International Edition in English, vol. 53, no. 17, pp. 4337-4340 . https://doi.org/10.1002/anie.201400681
Angewandte Chemie International Edition in English, 53(17), 4337-4340. John Wiley and Sons Ltd
Angewandte Chemie International Edition in English, 53(17), 4337-4340. John Wiley and Sons Ltd
Molecular templates bind particular reactants, thereby increasing their effective concentrations and accelerating the corresponding reaction. This concept has been successfully applied to a number of chemical problems with a strong focus on nucleic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655a1100e7d0f46994a4112a56cb262a
https://research.vu.nl/en/publications/c8b81aea-5288-4969-a2fe-57d53364be2c
https://research.vu.nl/en/publications/c8b81aea-5288-4969-a2fe-57d53364be2c
Publikováno v:
Scientific Reports
Signaling proteins often form dynamic protein-protein interaction (PPI) complexes to achieve multi-functionality. Methods to abrogate a subset of PPI interfaces without depleting the full-length protein will be valuable for structure-function relatio