Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Johannes Spehr"'
Autor:
Simon Loff, Josephine Dietrich, Jan-Erik Meyer, Julia Riewaldt, Johannes Spehr, Malte von Bonin, Cordula Gründer, Mridula Swayampakula, Kristin Franke, Anja Feldmann, Michael Bachmann, Gerhard Ehninger, Armin Ehninger, Marc Cartellieri
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 408-420 (2020)
Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of t
Externí odkaz:
https://doaj.org/article/3ec8614cd9884bca80538a5dcb151075
Autor:
Jan-Erik Meyer, Simon Loff, Josephine Dietrich, Johannes Spehr, Gabriel Jurado Jiménez, Malte von Bonin, Gerhard Ehninger, Marc Cartellieri, Armin Ehninger
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Chimeric antigen receptor T cells (CAR-T) targeting CD19 have achieved significant success in patients with B cell malignancies. To date, implementation of CAR-T in other indications remains challenging due to the lack of truly tumor-specific antigen
Externí odkaz:
https://doaj.org/article/413b3b69781449f3ae9defa64d390f1b
Autor:
Elham Pishali Bejestani, Marc Cartellieri, Ralf Bergmann, Armin Ehninger, Simon Loff, Michael Kramer, Johannes Spehr, Antje Dietrich, Anja Feldmann, Susann Albert, Martin Wermke, Michael Baumann, Mechthild Krause, Martin Bornhäuser, Gerhard Ehninger, Michael Bachmann, Malte von Bonin
Publikováno v:
OncoImmunology, Vol 6, Iss 10 (2017)
The universal modular chimeric antigen receptor (UniCAR) platform redirects CAR-T cells using a separated, soluble targeting module with a short half-life. This segregation allows precise controllability and flexibility. Herein we show that the UniCA
Externí odkaz:
https://doaj.org/article/4bae5199a0ed4757af8ff2122c120682
Autor:
Maren Bleckmann, Margitta Schürig, Fang-Fang Chen, Zen-Zen Yen, Nils Lindemann, Steffen Meyer, Johannes Spehr, Joop van den Heuvel
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149424 (2016)
The Baculovirus Expression Vector System (BEVS) is widely used to produce high amounts of recombinant proteins. Nevertheless, generating recombinant baculovirus in high quality is rather time-consuming and labor-intensive. Alternatively, virus-free e
Externí odkaz:
https://doaj.org/article/bc1c3b641d4e4e65bf39e9f9877de7d2
Autor:
Jan-Erik Meyer, Simon Loff, Johannes Spehr, Marc Cartellieri, Mridula Swayampakula, Anja Feldmann, Armin Ehninger, Malte von Bonin, Gerhard Ehninger, Josephine Dietrich, Michael Bachmann, Cordula Gründer, Kristin Franke, Julia Riewaldt
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss, Pp 408-420 (2020)
Molecular Therapy Oncolytics 17(2020), 408-420
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics 17(2020), 408-420
Molecular Therapy Oncolytics
Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1fc9916ab82f0e31555c5fbef7b009
http://www.sciencedirect.com/science/article/pii/S2372770520300590
http://www.sciencedirect.com/science/article/pii/S2372770520300590
Publikováno v:
Methods. 95:3-12
Stable mammalian production cell lines in suspension culture enable the reproducible expression of target genes in any desired scale using bioreactor technology. Targeted integration methods have been developed to cut down timelines for the generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2012f308167839f21870d200fc0a924e
https://doi.org/10.1016/j.ymeth.2015.11.022
https://doi.org/10.1016/j.ymeth.2015.11.022
Autor:
Gerhard Ehninger, Marc Cartellieri, Josephine Dietrich, Michael Pehl, Johannes Spehr, Simon Loff, Cordula Gründer, Julia Riewaldt, Armin Ehninger, Maria Schreiber, Michael Bachmann
Publikováno v:
Cancer Research. 80:2209-2209
Despite remarkable therapeutic success using chimeric antigen receptor modified T-cells (CAR-T) in hematologic malignancies, targeting solid tumors still remains challenging, given their heterogeneity and immunosuppressive milieu, including the expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1abcff2ab314867b66f8d6e6c43e213
https://doi.org/10.1158/1538-7445.am2020-2209
https://doi.org/10.1158/1538-7445.am2020-2209
Autor:
Simon Loff, Gerhard Ehninger, Mridula Swayampakula, Michael Pehl, Maria Schreiber, Julia Riewaldt, Armin Ehninger, Anja Feldmann, Cordula Gründer, Marc Cartellieri, Michael Bachmann, Johannes Spehr
Publikováno v:
Cancer Research. 80:2176-2176
CAR-T cell therapy holds great promise for treating a wide range of malignancies. Nevertheless, the CAR-T approach faces multiple challenges, including lack of suitable targets, insufficient tumor penetration and a microenvironment hostile to CAR-T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334201e133acca325a9565f96f9bdd76
https://doi.org/10.1158/1538-7445.am2020-2176
https://doi.org/10.1158/1538-7445.am2020-2176
Autor:
Jan-Erik Meyer, Marc Cartellieri, Johannes Spehr, Maria Schreiber, Gerhard Ehninger, Michael Pehl, Michael Bachmann, Simon Loff, Armin Ehninger, Cordula Gründer, Julia Riewaldt
Publikováno v:
Cancer Research. 80:4232-4232
Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 or BCMA is tremendously effective in treating hematological malignancies. However, the application of CAR-T beyond certain B-cell malignancies such as ALL, MM, lymphoma and CLL remains c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186e8b0da31a5e39f5249ed06ab06534
https://doi.org/10.1158/1538-7445.am2020-4232
https://doi.org/10.1158/1538-7445.am2020-4232
Autor:
Laura Köpping, Johannes Spehr, Madhu Nagaraj, Tobias Schubeis, Mumdooh Ahmed, Christiane Ritter, Janika Viereck
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 2018, 592 (6), pp.1020-1029. ⟨10.1002/1873-3468.13002⟩
FEBS Letters, Wiley, 2018, 592 (6), pp.1020-1029. ⟨10.1002/1873-3468.13002⟩
International audience; Curli are functional amyloids that form a major part of the biofilm produced by many enterobacteriaceae. A multiprotein system around the outer membrane protein CsgG is in charge of the export and controlled propagation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3dac36f001d2712fc2e4ca31236702
https://hal.archives-ouvertes.fr/hal-01767834
https://hal.archives-ouvertes.fr/hal-01767834
