Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Johannes Scheuring"'
Autor:
Horst Kessler, Franz Hagn, Sylvia Welker, Martin Haslbeck, Alfred Blume, Sevil Weinkauf, Gerhard Liebisch, Elke Frenzel, Andreas Kerth, Johannes Scheuring, Birgit Rudolph, Johannes Buchner, Gerd Schmitz
Publikováno v:
Molecular Cell. 39(4):507-520
Summary Hsp12 of S. cerevisiae is upregulated several 100-fold in response to stress. Our phenotypic analysis showed that this protein is important for survival of a variety of stress conditions, including high temperature. In the absence of Hsp12, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd80fcbf65d458a04aab3bcd90d85ca
Autor:
Sevil Weinkauf, Markus Fischer, Johannes Scheuring, Mark Cushman, Adelbert Bacher, Karl Kugelbrey
Publikováno v:
The Journal of Organic Chemistry. 66:3811-3819
The riboflavin synthase/lumazine synthase complex of Bacillus subtilis catalyzes the last two steps in riboflavin biosynthesis. The protein comprises a capsid of 60 β subunits with lumazine synthase activity and a core of three α subunits with ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3299dbb41e2e0b2afa8b7f5cc3d4f3d2
https://doi.org/10.1021/jo001739u
https://doi.org/10.1021/jo001739u
Autor:
Donald Oliver, John F. Hunt, Sevil Weinkauf, Lisa Henry, Johannes Scheuring, John J. Fak, Johann Deisenhofer
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 57:559-565
SecA is the peripheral membrane-associated subunit of the enzyme complex 'preprotein translocase' which assists the selective transport of presecretory proteins into and across bacterial membranes. The SecA protein acts as the molecular motor that dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc16dc656b4f722ae9a18d59b58c904
https://doi.org/10.1107/s0907444901001202
https://doi.org/10.1107/s0907444901001202
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:583-585
The gene coding for SecA from Enterococcus faecalis was cloned and overexpressed in Escherichia coli. In this protein, the lysine at position 6 was replaced by an asparagine in order to reduce sensitivity towards proteases. The modified protein was p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9338a1142fc19afacee25dc1cbfa03
https://doi.org/10.1107/s1744309106017544
https://doi.org/10.1107/s1744309106017544
Autor:
Johannes Scheuring, Vern L. Schramm
Publikováno v:
Biochemistry. 36:8215-8223
Pertussis toxin from Bordetella pertussis is one of the ADP-ribosylating toxins which are the cytotoxic agents of several infectious diseases. Transition state analogues of these enzymes are expected to be potent inhibitors and may be useful in thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59393c0a69f38429bb9dbaed577ec1f0
https://doi.org/10.1021/bi970379a
https://doi.org/10.1021/bi970379a
Autor:
Steven D. Schwartz, Paul J. Berti, Kathleen A. Rising, David W. Parkin, David J. Merkler, Vern L. Schramm, Benjamin A. Horenstein, Johannes Scheuring, Carey K. Bagdassarian, Paul C. Kline
Publikováno v:
International Journal of Quantum Chemistry. 60:1805-1813
rn A procedure is described which leads to experimentally based models for the transitionstate structures of enzyme-catalyzed reactions. Substrates for an enzymic reaction are synthesized with isotopically enriched atoms at every position in which bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4ec9ad23c24c7da4a6b7fb2fda433c8
https://doi.org/10.1002/(sici)1097-461x(1996)60:8<1805::aid-qua8>3.0.co
https://doi.org/10.1002/(sici)1097-461x(1996)60:8<1805::aid-qua8>3.0.co
Publikováno v:
The journal of biological chemistry 287(25), 21326-21334 (2012). doi:10.1074/jbc.M112.356659
Pathogenic generation of amyloid β-peptide (Aβ) by sequential cleavage of β-amyloid precursor protein (APP) by β- and γ-secretases is widely believed to causally underlie Alzheimer disease (AD). β-Secretase initially cleaves APP thereby generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53372a6deee4dab521a68e6963aeebe0
Publikováno v:
The Journal of Organic Chemistry. 58:4033-4042
6-(Trifluoromethyl)-8-(D-ribityl)lumazine (17) was synthesized in order to study its reactivity at C-7 and its binding to riboflavin synthase of Bacillus subtilis. Compound 17 was prepared by reaction of 5-amino-4-[(D-ribityl)amino]-2,4-(1H,3H)-pyrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3057b57813d2c6d04ca1caa75761281c
https://doi.org/10.1021/jo00067a041
https://doi.org/10.1021/jo00067a041
Autor:
Karl Kugelbrey, Mark Cushman, Markus Fischer, Adelbert Bacher, Sevil Weinkauf, Johannes Scheuring
Publikováno v:
ChemInform. 32
The riboflavin synthase/lumazine synthase complex of Bacillus subtilis catalyzes the last two steps in riboflavin biosynthesis. The protein comprises a capsid of 60 β subunits with lumazine synthase activity and a core of three α subunits with ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::669e80c9233260e38ae5ac5522ffefaa
https://doi.org/10.1002/chin.200137218
https://doi.org/10.1002/chin.200137218
Publikováno v:
The Journal of Organic Chemistry. 57:5630-5643
The reactions of hexafluoropropene oxide (19), methyl trifluoropyruvate (21), and 1,1,1-trifluorobutane-2,3-dione (45) with a series of ortho diamines were investigated as an approach to the synthesis of trifluoromethyl-substituted quinoxalinones and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::482426bf69ef3664a46c27cac5c3f954
https://doi.org/10.1021/jo00047a015
https://doi.org/10.1021/jo00047a015