Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Johannes S P, Doehl"'
Autor:
Joshua R. Lacsina, Ryan Kissinger, Johannes S. P. Doehl, Maria M. Disotuar, George Petrellis, Mara Short, Elliot Lowe, James Oristian, Daniel Sonenshine, Thiago DeSouza-Vieira
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
Infections caused by vector-borne pathogens impose a significant burden of morbidity and mortality in a global scale. In their quest for blood, hematophagous arthropods penetrate the host skin and may transmit pathogens by the bite. These pathogens a
Externí odkaz:
https://doaj.org/article/52a5528e4a67468f9b16012cd43658b9
Autor:
Daniel Paape, Catriona T. Prendergast, Helen P. Price, Johannes S. P. Doehl, Deborah F. Smith
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Background Proving that specific genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identification of suitable targets for drug development. This is especially evident i
Externí odkaz:
https://doaj.org/article/463f0595daaf427186f4594b3dbf6a5a
Autor:
Johannes S. P. Doehl, Helen Ashwin, Najmeeyah Brown, Audrey Romano, Samuel Carmichael, Jon W. Pitchford, Paul M. Kaye
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increasing evidence suggests that in hosts infected with parasites of the Leishmania donovani complex, transmission of infection to the sand fly vector is linked to parasite repositories in the host skin. However, a detailed understanding of the disp
Externí odkaz:
https://doaj.org/article/ca71750692914a0eba30319da4de6ac7
Autor:
Audrey Romano, Najmeeyah Brown, Helen Ashwin, Johannes S. P. Doehl, Jonathan Hamp, Mohamed Osman, Nidhi Dey, Gulab Fatima Rani, Tiago Rodrigues Ferreira, Paul M. Kaye
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Ly6Chi inflammatory monocytes develop in the bone marrow and migrate to the site of infection during inflammation. Upon recruitment, Ly6Chi monocytes can differentiate into dendritic cells or macrophages. According to the tissue environment they can
Externí odkaz:
https://doaj.org/article/7cd5cbb708ee478fb20c92a32723f93d
Autor:
Johannes S. P. Doehl, Zoe Bright, Shoumit Dey, Helen Davies, John Magson, Najmeeyah Brown, Audrey Romano, Jane E. Dalton, Ana I. Pinto, Jon W. Pitchford, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Parasitemia has been considered the main determinant of visceral leishmaniasis transmission. By combining imaging, qPCR and experimental xenodiagnoses with mathematical models, Doehl et al. argue that the patchy landscape of parasites in the skin is
Externí odkaz:
https://doaj.org/article/3a887a193dae46a98016881baf0ef70e
Autor:
Changsheng Deng, Wanting Wu, Yueming Yuan, Guoming Li, Hongying Zhang, Shaoqin Zheng, Mingqiang Li, Ruixiang Tan, Yuxin Wang, Julie Nadia, Danhong Feng, Di Li, Zhibing Wu, Qin Xu, Changqing Li, Zhenhua Wang, Yuan Liang, Johannes S P Doehl, Xinzhuan Su, Affane Bacar, Kamal Said Abdallah, Hafidhou Mohamed, Ahamada Msa Mliva, Thomas E Wellems, Jianping Song
Publikováno v:
Open Forum Infect Dis
BackgroundMass drug administration (MDA) is a powerful tool for malaria control, but the medicines to use, dosing, number of rounds, and potential selection of drug resistance remain open questions.MethodsTwo monthly rounds of artemisinin-piperaquine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2caece9d674f4689400b0f80e726e2d9
https://europepmc.org/articles/PMC10003749/
https://europepmc.org/articles/PMC10003749/
Autor:
Seong-Kyun, Lee, Leanne M, Low, John F, Andersen, Lee M, Yeoh, Paola Carolina, Valenzuela Leon, Damien R, Drew, Johannes S P, Doehl, Eric, Calvo, Louis H, Miller, James G, Beeson, Karthigayan, Gunalan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
We used a transgenic parasite in which
Autor:
Daniel M. Parker, Catalina Medina, Jennifer Bohl, Chanthap Lon, Sophana Chea, Sreyngim Lay, Dara Kong, Sreynik Nhek, Somnang Man, Johannes S. P. Doehl, Rithea Leang, Hok Kry, Huy Rekol, Fabiano Oliveira, Vladimir Minin, Jessica E. Manning
Aedes mosquitoes are some of the most important and globally expansive vectors of disease. Public health efforts are largely focused on prevention of human-vector contact. A range of entomological indices are used to measure risk of disease, though w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cc4cfccb20dc04bc870a09568619913
https://doi.org/10.1101/2022.09.12.22278870
https://doi.org/10.1101/2022.09.12.22278870
Autor:
Ana Isabel Pinto, Najmeeyah Brown, Olivier Preham, Johannes S P Doehl, Helen Ashwin, Paul M Kaye
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006465 (2017)
Visceral leishmaniasis is associated with significant changes in hematological function but the mechanisms underlying these changes are largely unknown. In contrast to naïve mice, where most long-term hematopoietic stem cells (LT-HSCs; LSK CD150+ CD
Externí odkaz:
https://doaj.org/article/b0c5ecbf22f146508a62c512174ef190
Autor:
Johannes S P Doehl, Jovana Sádlová, Hamide Aslan, Kateřina Pružinová, Sonia Metangmo, Jan Votýpka, Shaden Kamhawi, Petr Volf, Deborah F Smith
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006130 (2017)
Differentiation of extracellular Leishmania promastigotes within their sand fly vector, termed metacyclogenesis, is considered to be essential for parasites to regain mammalian host infectivity. Metacyclogenesis is accompanied by changes in the local
Externí odkaz:
https://doaj.org/article/f22e4113196f4c809bff01e7f717e6f5