Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Johannes S Gach"'
Publikováno v:
Microbial Cell, Vol 11, Pp 207-220 (2024)
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine development.
Externí odkaz:
https://doaj.org/article/e1c5017d69c54b9193b85c417929f408
Autor:
Johannes S Gach, Margaux Bouzin, Marcus P Wong, Veronika Chromikova, Andrea Gorlani, Kuan-Ting Yu, Brijesh Sharma, Enrico Gratton, Donald N Forthal
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006793 (2017)
Fc gamma receptor (FcyR)-mediated antibody functions play a crucial role in preventing HIV infection. One such function, antibody-dependent phagocytosis (ADP), is thought to be involved in controlling other viral infections, but its role in HIV infec
Externí odkaz:
https://doaj.org/article/c22ce69122db4bc69268a7b16cd7a283
Autor:
Johannes S Gach, Andrea Gorlani, Emmanuel Y Dotsey, Juan C Becerra, Chase T M Anderson, Baiba Berzins, Philip L Felgner, Donald N Forthal, Steven G Deeks, Timothy J Wilkin, Joseph P Casazza, Richard A Koup, Christine Katlama, Brigitte Autran, Robert L Murphy, Chad J Achenbach
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo
Externí odkaz:
https://doaj.org/article/05060ed186404214b00da813729017ee
Autor:
Emmanuel Y Dotsey, Andrea Gorlani, Sampat Ingale, Chad J Achenbach, Donald N Forthal, Philip L Felgner, Johannes S Gach
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125581 (2015)
In recent years, high throughput discovery of human recombinant monoclonal antibodies (mAbs) has been applied to greatly advance our understanding of the specificity, and functional activity of antibodies against HIV. Thousands of antibodies have bee
Externí odkaz:
https://doaj.org/article/25114a3849f94a04b1c16365d00d3290
Autor:
Johannes S Gach, Chad J Achenbach, Veronika Chromikova, Baiba Berzins, Nina Lambert, Gary Landucci, Donald N Forthal, Christine Katlama, Barbara H Jung, Robert L Murphy
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85371 (2014)
The majority of potent and broadly neutralizing antibodies against HIV-1 have been isolated from untreated patients with acute or chronic infection. To assess the extent of HIV-1 specific antibody response and neutralization after many years of virol
Externí odkaz:
https://doaj.org/article/20ac70da0b2f42199b8eb76323aa07fa
Autor:
Sandeep Gupta, Johannes S Gach, Juan C Becerra, Tran B Phan, Jeffrey Pudney, Zina Moldoveanu, Sarah B Joseph, Gary Landucci, Medalyn Jude Supnet, Li-Hua Ping, Davide Corti, Brian Moldt, Zdenek Hel, Antonio Lanzavecchia, Ruth M Ruprecht, Dennis R Burton, Jiri Mestecky, Deborah J Anderson, Donald N Forthal
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003776 (2013)
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination
Externí odkaz:
https://doaj.org/article/fc81d5d35a084780ba7fe91dd2ceb47a
Autor:
Johannes S Gach, Heribert Quendler, Tommy Tong, Kristin M Narayan, Sean X Du, Robert G Whalen, James M Binley, Donald N Forthal, Pascal Poignard, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72054 (2013)
Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally pot
Externí odkaz:
https://doaj.org/article/cce40e1dc2ad4d5893581ac52a615e3f
Autor:
Laura M Walker, Melissa D Simek, Frances Priddy, Johannes S Gach, Denise Wagner, Michael B Zwick, Sanjay K Phogat, Pascal Poignard, Dennis R Burton
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001028 (2010)
A protective vaccine against HIV-1 will likely require the elicitation of a broadly neutralizing antibody (bNAb) response. Although the development of an immunogen that elicits such antibodies remains elusive, a proportion of HIV-1 infected individua
Externí odkaz:
https://doaj.org/article/f2544dd28dca4c528b05e84427b0f5fa
Autor:
Kyle J Nakamura, Johannes S Gach, Laura Jones, Katherine Semrau, Jan Walter, Frederic Bibollet-Ruche, Julie M Decker, Laura Heath, William D Decker, Moses Sinkala, Chipepo Kankasa, Donald Thea, James Mullins, Louise Kuhn, Michael B Zwick, Grace M Aldrovandi
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9786 (2010)
Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER) of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine devel
Externí odkaz:
https://doaj.org/article/e38757135abe4c1594c7b6074c0a896f
Autor:
Gernot Beihammer, Julia König-Beihammer, Benjamin Kogelmann, Valentina Ruocco, Clemens Grünwald-Gruber, Marc-André D’Aoust, Pierre-Olivier Lavoie, Pooja Saxena, Johannes S. Gach, Herta Steinkellner, Richard Strasser
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays an important role for antibody structure and effector functions. While numerous recombinant IgG1 antibodies have been successfully expressed in plants, they frequ
Externí odkaz:
https://doaj.org/article/62254be10de741a5a9334471bd4f6fa3