Are long-term exposure studies needed? Short-term toxicokinetic model predicts the uptake of metal nanoparticles in earthworms after nine months

Autor: Marta Baccaro, Johannes H.J. van den Berg, Nico W. van den Brink

Publikováno v: Ecotoxicology and Environmental Safety, Vol 220, Iss , Pp 112371- (2021)

Uptake of most metal nanoparticles (NPs) in organisms is assumed to be mainly driven by the bioavailability of the released ions, as has been verified in controlled and short-term exposure tests. However, the changeability of NPs and the dynamic proc

Externí odkaz: https://doaj.org/article/81ab50404e054a6481eb6e5348d21679

Plasma bioavailability and changes in PBMC gene expression after treatment of ovariectomized rats with a commercial soy supplement

Autor: Mohammed A. Islam, Guido J.E.J. Hooiveld, Johannes H.J. van den Berg, Mark V. Boekschoten, Vera van der Velpen, Albertinka J. Murk, Ivonne M.C.M. Rietjens, F.X. Rolaf van Leeuwen

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 308-321 (2015)

The health effects of soy supplementation in (post)menopausal women are still a controversial issue. The aim of the present study was to establish the effect of the soy isoflavones (SIF) present in a commercially available supplement on ovariectomize

Externí odkaz: https://doaj.org/article/c9dfe927e8084bcead69cf27d5b1ab6e

Utility of the SmartPilot® View advisory screen to improve anaesthetic drug titration and postoperative outcomes in clinical practice: a two-centre prospective observational trial

Autor: Merel H. Kuizenga, Hugo E.M. Vereecke, Anthony R. Absalom, Christian H. Bucher, Laura N. Hannivoort, Johannes P. van den Berg, Livia Schmalz, Michel M.R.F. Struys, Martin Luginbühl

Publikováno v: British Journal of Anaesthesia, 128(6), 959-970. ELSEVIER SCI LTD
Kuizenga, Merel H; Vereecke, Hugo E M; Absalom, Anthony R; Bucher, Christian H; Hannivoort, Laura N; van den Berg, Johannes P; Schmalz, Livia; Struys, Michel M R F; Luginbühl, Martin (2022). Utility of the SmartPilot® View advisory screen to improve anaesthetic drug titration and postoperative outcomes in clinical practice: a two-centre prospective observational trial. British journal of anaesthesia, 128(6), pp. 959-970. Elsevier 10.1016/j.bja.2022.02.033

BACKGROUND The advisory system SmartPilot® View (Drägerwerk AG, Lübeck, Germany) provides real-time, demographically adjusted pharmacodynamic information throughout anaesthesia, including time course of effect-site concentrations of administered d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f364bcb7cbdae708fc3ca14325cee4
https://pubmed.ncbi.nlm.nih.gov/35361490

Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations

Autor: Johannes P van den Berg, Michel Struys, Cyrill Hornuss, Douglas J. Eleveld, Gustav Schelling, Christian C. Apfel, Pieter Colin, Hugo Vereecke

Publikováno v: Clinical Pharmacokinetics, 55(7), 849-859. Springer International Publishing AG

Introduction Monitoring of drug concentrations in breathing gas is routinely being used to individualize drug dosing for the inhalation anesthetics. For intravenous anesthetics however, no decisive evidence in favor of breath concentration monitoring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da06c16040b3e4f4c2b88ffd555d2043
https://doi.org/10.1007/s40262-015-0358-z