Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Johannes P. W. Heidbuechel"'
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-24 (2021)
Abstract Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities hav
Externí odkaz:
https://doaj.org/article/17f684d9d71746339f5189e4f47a4dd7
Autor:
Miryam Müller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Röder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Publikováno v:
Cells, Vol 11, Iss 17, p 2683 (2022)
Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding. ADAM17 is involved in the processing of multiple
Externí odkaz:
https://doaj.org/article/a9ea442961a64afa94499ce585b8ac1d
Autor:
Elena Busch, Kristina D. Kubon, Johanna K. M. Mayer, Gemma Pidelaserra-Martí, Jessica Albert, Birgit Hoyler, Johannes P. W. Heidbuechel, Kyle B. Stephenson, Brian D. Lichty, Wolfram Osen, Stefan B. Eichmüller, Dirk Jäger, Guy Ungerechts, Christine E. Engeland
Publikováno v:
Viruses, Vol 12, Iss 2, p 242 (2020)
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of onc
Externí odkaz:
https://doaj.org/article/9af18000f98945f6b2fe4a914b25707b
Autor:
Daniel N. Santiago, Johannes P. W. Heidbuechel, Wendy M. Kandell, Rachel Walker, Julie Djeu, Christine E. Engeland, Daniel Abate-Daga, Heiko Enderling
Publikováno v:
Viruses, Vol 9, Iss 9, p 239 (2017)
After decades of research, oncolytic virotherapy has recently advanced to clinical application, and currently a multitude of novel agents and combination treatments are being evaluated for cancer therapy. Oncolytic agents preferentially replicate in
Externí odkaz:
https://doaj.org/article/29014af98f2f4594868865840d5358d4
Autor:
Tobias Speck, Christof von Kalle, Guy Ungerechts, Christine E. Engeland, Rūta Veinalde, Johannes P W Heidbuechel, Claudia R. Ball, Dirk Jaeger
Publikováno v:
Clinical Cancer Research. 24:2128-2137
Purpose: Immunotherapy with bispecific T-cell engagers has achieved striking success against hematologic malignancies, but efficacy against solid tumors has been limited. We hypothesized that oncolytic measles viruses encoding bispecific T-cell engag
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2058
Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypo
Publikováno v:
Methods in Molecular Biology ISBN: 9781493997930
Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025679d1efb8bd5ae47fe981b588aef5
https://doi.org/10.1007/978-1-4939-9794-7_21
https://doi.org/10.1007/978-1-4939-9794-7_21
Autor:
Johannes P W Heidbuechel, Heiko Enderling, Daniel N. Santiago, Wendy M. Kandell, Christine E. Engeland, Rachel Walker, Daniel Abate-Daga
After decades of research, oncolytic virotherapy has recently advanced to clinical application, and currently a multitude of novel agents and combination treatments are being evaluated for cancer therapy. Oncolytic agents preferentially replicate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6f0a9d3c076d966e8076d72c657470
https://doi.org/10.20944/preprints201707.0045.v1
https://doi.org/10.20944/preprints201707.0045.v1
Autor:
Tobias Speck, Birgit Hoyler, Johannes P W Heidbuechel, Elena S. Czink, Guy Ungerechts, Jessica Albert, Christof von Kalle, Dirk Jaeger, Christine E. Engeland
Publikováno v:
Molecular Therapy. 24:S30
Oncolytic viruses directly reduce tumor burden by selective lytic replication in malignant cells, which designates these vectors as a potent platform for targeted cancer therapy. Lately the focus of oncolytic research has shifted towards the immunost