Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Johannes P. Schimming"'
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Akademický článek
Identifying multiscale translational safety biomarkers using a network-based systems approach
Autor: Giulia Callegaro, Johannes P. Schimming, Janet Piñero González, Steven J. Kunnen, Lukas Wijaya, Panuwat Trairatphisan, Linda van den Berk, Kim Beetsma, Laura I. Furlong, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens, Bob van de Water
Publikováno v: iScience, Vol 26, Iss 3, Pp 106094- (2023)
Summary: Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can address the species translation but might not replicate in vivo complexity. Herein, we
Externí odkaz: https://doaj.org/article/c1ec17ac979040d09bc96f5bae7f9e91
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2
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Autor: Erika Moro, Johannes P Schimming, José V. Castell, Bas ter Braak, Laia Tolosa, Barbara M.A. van Vugt-Lussenburg, Bob van der Water, Teresa Martínez-Sena, Miguel A. Miranda, Sylvia Escher
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Archives of Toxicology, 95(6), 2109-2121. Springer Science and Business Media LLC
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Archives of Toxicology
Phenols are regarded as highly toxic chemicals. Their effects are difficult to study in in vitro systems because of their ambiguous fate (degradation, auto-oxidation and volatility). In the course of in vitro studies of a series of redox-cycling phen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b272012eddeb7cdefeccbea6af2290
https://doi.org/10.1007/s00204-021-03036-w
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3
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
Autor: Paul Jennings, Giada Carta, Johannes P Schimming, Erik H.J. Danen, Marcel Leist, Giulia Callegaro, Nanette G Vrijenhoek, Joost B. Beltman, Anna Forsby, Johannes Delp, Andrew White, Bob van de Water, Sylvia E. Le Dévédec, Huan Yang, Wanda van der Stel, Salihanur Darici
Publikováno v: van der Stel, W, Yang, H, Vrijenhoek, N G, Schimming, J P, Callegaro, G, Carta, G, Darici, S, Delp, J, Forsby, A, White, A, le Dévédec, S, Leist, M, Jennings, P, Beltman, J B, van de Water, B & Danen, E H J 2022, ' Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation ', Archives of Toxicology, vol. 96, no. 1, pp. 259-285 . https://doi.org/10.1007/s00204-021-03160-7
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlag
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e5ec3b4fb4c6608dfe265e2934a630
https://hdl.handle.net/1871.1/e0b19077-5a27-48fb-bc1b-0dc3bbb415f8
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4
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
Autor: Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
Publikováno v: Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461
Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is presented. It details all proce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e81d40cbe9c93d9b654557d3afcabe
https://hdl.handle.net/1887/3184413
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6
System Microscopy of Stress Response Pathways in Cholestasis Research
Autor: Johannes P, Schimming, Bas, Ter Braak, Marije, Niemeijer, Steven, Wink, Bob, van de Water
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1981
Exposure to oxidative radical species and cytokine-mediated inflammatory stress are established contributors to hepatocyte cell death during cholestasis. Cellular counter measures against those stressors are called adaptive stress response pathways.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::191a32d0e84afa575cee5f745caac832
https://pubmed.ncbi.nlm.nih.gov/31016656
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7
System Microscopy of Stress Response Pathways in Cholestasis Research
Autor: Bob van de Water, Bas ter Braak, Johannes P Schimming, Marije Niemeijer, Steven Wink
Publikováno v: Methods in Molecular Biology
Methods in Molecular Biology-Experimental Cholestasis Research
Methods in Molecular Biology ISBN: 9781493994199
Exposure to oxidative radical species and cytokine-mediated inflammatory stress are established contributors to hepatocyte cell death during cholestasis. Cellular counter measures against those stressors are called adaptive stress response pathways.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2ea39f0fc4cb2516ba5cf7211ba536
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8
A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
Autor: Joost B. Beltman, Jan P. Langenberg, Johannes P Schimming, Luc J M Bischoff, Bob van de Water, Isoude A. Kuijper, Bas ter Braak, Daan Noort, Liesanne Wolters
Publikováno v: Archives of Toxicology
Archives of Toxicology, 93(2), 435-451
Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3e4229c58ccc0324a67ca859a46d12
http://resolver.tudelft.nl/uuid:e3a549dd-28c5-486d-ae29-d8001b12af8f
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