Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Johannes Neidhart"'
Autor:
Stefan Nowak, Johannes Neidhart, Ivan G. Szendro, Jonas Rzezonka, Rahul Marathe, Joachim Krug
Publikováno v:
Biology, Vol 7, Iss 1, p 6 (2018)
A long-standing problem in ageing research is to understand how different factors contributing to longevity should be expected to act in combination under the assumption that they are independent. Standard interaction analysis compares the extension
Externí odkaz:
https://doaj.org/article/1dbdebf09e044d0da2200e9e41756f24
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003836 (2014)
Identifying and quantifying the benefits of sex and recombination is a long-standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness land
Externí odkaz:
https://doaj.org/article/530d4cd7e96b42bfad66f44bc0440736
Autor:
Joachim Krug, Ivan G. Szendro, Stefan Nowak, Johannes Neidhart, Jonas Rzezonka, Rahul Marathe
A long-standing problem in ageing research is to understand how different factors contributing to longevity should be expected to act in combination under the assumption that they are independent. Standard epistasis analysis compares the extension of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73295237080d0004166d0f390796e40
https://doi.org/10.1101/147173
https://doi.org/10.1101/147173
Autor:
Johannes Neidhart, Rahul Marathe, Ivan G. Szendro, Joachim Krug, Stefan Nowak, Jonas Rzezonka
Publikováno v:
Biology, Vol 7, Iss 1, p 6 (2018)
Biology
Biology; Volume 7; Issue 1; Pages: 6
Biology
Biology; Volume 7; Issue 1; Pages: 6
A long-standing problem in ageing research is to understand how different factors contributing to longevity should be expected to act in combination under the assumption that they are independent. Standard interaction analysis compares the extension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eb8f03eb915c257003acc569581d3b
https://doi.org/10.3390/biology7010006
https://doi.org/10.3390/biology7010006
We study adaptation of a haploid asexual population on a fitness landscape defined over binary genotype sequences of length $L$. We consider greedy adaptive walks in which the population moves to the fittest among all single mutant neighbors of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f22a9f95aac024912123579eafc76
http://arxiv.org/abs/1507.03511
http://arxiv.org/abs/1507.03511
Publikováno v:
Physical Review E. 91
We study biological evolution on a random fitness landscape where correlations are introduced through a linear fitness gradient of strength $c$. When selection is strong and mutations rare the dynamics is a directed uphill walk that terminates at a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0364f6a7def3e3d4448d25b3180058
https://doi.org/10.1103/physreve.91.042707
https://doi.org/10.1103/physreve.91.042707
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003836 (2014)
PLoS Computational Biology
PLoS Computational Biology
Identifying and quantifying the benefits of sex and recombination is a long standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness land
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9cfb2832a33c623ad753c8dc293c33
http://europepmc.org/articles/PMC4168978?pdf=render
http://europepmc.org/articles/PMC4168978?pdf=render
Publikováno v:
Genetics. 198(2)
Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad603bfce63abe4a21aaa6ef25ed6971
https://pubmed.ncbi.nlm.nih.gov/25123507
https://pubmed.ncbi.nlm.nih.gov/25123507
Publikováno v:
Journal of theoretical biology. 332
Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by P.F. Stadler [J. Math. Chem. 20, 1 (1996)] for common landscape models, including Kauffman's NK-model, rough Mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6840be474726639705f31fb7573b92
https://pubmed.ncbi.nlm.nih.gov/23685065
https://pubmed.ncbi.nlm.nih.gov/23685065
Autor:
Johannes Neidhart, Joachim Krug
We study biological evolution in a high-dimensional genotype space in the regime of rare mutations and strong selection. The population performs an uphill walk which terminates at local fitness maxima. Assigning fitness randomly to genotypes, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f27f7da5ce57fe8cc928904cd3edb32