Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Johannes Martensson"'
Publikováno v:
Metabolism. 41:273-277
Cerebral cortex, heart, skeletal muscle, and liver mitochondrial glutathione (GSH) levels in severely burned rats are decreased to between approximately 50% to 70% of sham-operated, normally fed controls. In semistarved rats, weight-matched with burn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eec21abcf3b84026ad568533df2eba2
https://doi.org/10.1016/0026-0495(92)90270-k
https://doi.org/10.1016/0026-0495(92)90270-k
Autor:
Ajey Jain, Alton Meister, William W. Frayer, Peter A. M. Auld, Einar Stole, Johannes Martensson
Publikováno v:
Proceedings of the National Academy of Sciences. 88:9360-9364
A model for oxidative stress is described in which glutathione (GSH) synthesis is selectively blocked in newborn rats by administration of L-buthionine-(S,R)-sulfoximine (BSO). In this model, the normal endogenous physiological formation of reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa21205cb1a7f5a67c8d1fb9d28ed85
https://doi.org/10.1073/pnas.88.20.9360
https://doi.org/10.1073/pnas.88.20.9360
Publikováno v:
Proceedings of the National Academy of Sciences. 87:7185-7189
Glutathione, an essential cellular antioxidant required for mitochondrial function, is not synthesized by mitochondria but is imported from the cytosol. Rat liver mitochondria have a multicomponent system that underlies the remarkable ability of mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1660fd8cc99dc714a2cd8e6cf2cd6d4
https://doi.org/10.1073/pnas.87.18.7185
https://doi.org/10.1073/pnas.87.18.7185
Autor:
Alton Meister, Johannes Martensson
Publikováno v:
Proceedings of the National Academy of Sciences. 89:11566-11568
Glutathione deficiency, induced in adult mice by administering buthionine sulfoximine (an inhibitor of glutathione synthesis), led to a rapid and substantial increase in ascorbate in the liver. This effect was apparent 2-4 hr after giving the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c500c955669d400b4a5dc7bb768ff1
https://doi.org/10.1073/pnas.89.23.11566
https://doi.org/10.1073/pnas.89.23.11566
Autor:
Peter A. M. Auld, Robert F. Ward, Johannes Martensson, Jose Rodrigues, Ajey Jain, Morton K. Schwartz, Taral Mehta
Publikováno v:
Pediatric pulmonology. 20(3)
Respiratory distress in premature newborns is associated with deficiency of surfactant in the bronchoalveolar lining fluid; this may be influenced by a local deficiency of antioxidants. Severe L-buthionine-S,R-sulfoximine-induced depletion of glutath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c433c2711a1b2d06e9638cf797da1
https://pubmed.ncbi.nlm.nih.gov/8545167
https://pubmed.ncbi.nlm.nih.gov/8545167
Autor:
Nancy G. Kennaway, Johannes Martensson, Peter A. M. Auld, Ajey Jain, Neil R. M. Buist, Berkley R. Powell
Publikováno v:
The Journal of pediatrics. 124(2)
A 45-month-old girl with 5-oxoprolinuria (pyroglutamic aciduria), hemolysis, and marked glutathione depletion caused by deficiency of glutathione synthetase was followed before and during treatment with ascorbate or N-acetylcysteine. High doses of as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fecd0072682dd93cac64b3a14e65f4a
https://pubmed.ncbi.nlm.nih.gov/8301428
https://pubmed.ncbi.nlm.nih.gov/8301428
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(1)
Previous studies showed that administration of ascorbate to glutathione (GSH)-deficient newborn rats and guinea pigs prevented toxicity and mortality and led to increased tissue and mitochondrial GSH levels; ascorbate thus spares GSH. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cddbdfece9c5eae6e7ef8af96a27dd
https://pubmed.ncbi.nlm.nih.gov/8419936
https://pubmed.ncbi.nlm.nih.gov/8419936
Autor:
Johannes Martensson, Ajey Jain, Alton Meister, Peter A. M. Auld, Alfred N. Krauss, Taral Mehta
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(11)
Glutathione deficiency in adult mice leads to lung type 2 cell lamellar body and mitochondrial damage; as reported here, these effects are associated with marked decrease of the levels of phosphatidylcholine (the main component of lung surfactant) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed07bbab848340ed60566e2ed551c61
https://pubmed.ncbi.nlm.nih.gov/1594617
https://pubmed.ncbi.nlm.nih.gov/1594617
Glutathione deficiency in newborn rats, produced by administration of L-buthionine-(S,R)-sulfoximine, a transition-state inactivator of gamma-glutamylcysteine synthetase, decreases ascorbate levels of kidney, liver, brain, and lung. These tissues, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0453b1f968a931dac00ca1a38e2f23
https://europepmc.org/articles/PMC51724/
https://europepmc.org/articles/PMC51724/
Publikováno v:
Brain research. 518(1-2)
Buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis, is poorly transported into the brain of adult mice, and only a slight decrease (approximately 10%) in the level of brain glutathione is found 30-60 min after intraperitoneal adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7339d03fd8fafbf17ced3f57a6a6410
https://pubmed.ncbi.nlm.nih.gov/2390716
https://pubmed.ncbi.nlm.nih.gov/2390716