Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Johannes M. Aerts"'
Autor:
Or Cabasso, Aparna Kuppuramalingam, Lindsey Lelieveld, Martijn Van der Lienden, Rolf Boot, Johannes M. Aerts, Mia Horowitz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16035 (2023)
In Gaucher disease (GD), a relatively common sphingolipidosis, the mutant lysosomal enzyme acid β-glucocerebrosidase (GCase), encoded by the GBA1 gene, fails to properly hydrolyze the sphingolipid glucosylceramide (GlcCer) in lysosomes, particularly
Externí odkaz:
https://doaj.org/article/a40a9c1486d74af0b5d3a6715e7fdbcb
Autor:
Daphne E. Boer, Mina Mirzaian, Maria J. Ferraz, Kimberley C. Zwiers, Merel V. Baks, Marc D. Hazeu, Roelof Ottenhoff, André R.A. Marques, Rianne Meijer, Jonathan C.P. Roos, Timothy M. Cox, Rolf G. Boot, Navraj Pannu, Herman S. Overkleeft, Marta Artola, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100018- (2021)
Abstract: Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GB
Externí odkaz:
https://doaj.org/article/bde0e1b5189144b6972b5caa64f21aff
Autor:
AndréR.A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, CindyP.A.A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 451-463 (2016)
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA) and GBA2, located in and outside the lysosome, respectively. Here we demonstrate that throu
Externí odkaz:
https://doaj.org/article/57f08df9b338494281ce0b82ea7d752a
Autor:
Evi Vlassaks, Chiara Mencarelli, Maria Nikiforou, Eveline Strackx, Maria J. Ferraz, Johannes M. Aerts, Marc H. De Baets, Pilar Martinez-Martinez, Antonio W.D. Gavilanes
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1825-1833 (2013)
Fetal asphyctic preconditioning, induced by a brief episode of experimental hypoxia-ischemia, offers neuroprotection to a subsequent more severe asphyctic insult at birth. Extensive cell stress and apoptosis are important contributing factors of dama
Externí odkaz:
https://doaj.org/article/caacee4cd95e401aae3672a9b06b0af9
Autor:
Carlos L.J. Vrins, Roelof Ottenhoff, Karin van den Oever, Dirk R. de Waart, J. Kar Kruyt, Ying Zhao, Theo J.C. van Berkel, Louis M. Havekes, Johannes M. Aerts, Miranda van Eck, Patrick C.N. Rensen, Albert K. Groen
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2017-2023 (2012)
Transintestinal cholesterol efflux (TICE) provides an attractive target to increase body cholesterol excretion. At present, the cholesterol donor responsible for direct delivery of plasma cholesterol to the intestine is unknown. In this study, we inv
Externí odkaz:
https://doaj.org/article/699f266aedbf4186933a17a483e49497
Autor:
Johannes M, Aerts, Rolf G, Boot, Marco, van Eijk, Johanna, Groener, Nora, Bijl, Elisa, Lombardo, Florence M, Bietrix, Nick, Dekker, Albert K, Groen, Roelof, Ottenhoff, Cindy, van Roomen, Jan, Aten, Mireille, Serlie, Mirjam, Langeveld, Tom, Wennekes, Hermen S, Overkleeft
Publikováno v:
Advances in experimental medicine and biology. 721
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A c
Autor:
M. de Fost, Esther P. M. Tjin, Rolf G. Boot, Mario Maas, T. A. Out, M. H. J. Van Oers, Steven T. Pals, Johannes M. Aerts, S. vom Dahl, C.E.M. Hollak, F. A. de Wilde
Publikováno v:
Annals of Hematology
Annals of Hematology, 87(6), 439-449
ResearcherID
Annals of hematology, 87(6), 439-449. Springer Verlag
Annals of Hematology, 87(6), 439-449
ResearcherID
Annals of hematology, 87(6), 439-449. Springer Verlag
Gaucher disease type I, the most common lysosomal storage disorder, is associated with immunoglobulin abnormalities. We studied the prevalence, risk factors, pathogenesis, and effect of enzyme relation therapy (ERT) on gammopathies in an adult Gauche
Publikováno v:
International review of cytology. 252
Gaucher disease (GD) is the most common lysosomal storage disorder and is caused by inherited deficiencies of glucocerebrosidase, the enzyme responsible for the lysosomal breakdown of the lipid glucosylceramide. GD is characterized by the accumulatio
Autor:
Leonie A, Boven, Marjan, van Meurs, Rolf G, Boot, Atul, Mehta, Louis, Boon, Johannes M, Aerts, Jon D, Laman
Publikováno v:
American journal of clinical pathology. 122(3)
Although the existence of anti-inflammatory alternatively activated macrophages (aamphi) has been accepted widely based on in vitro studies, their in vivo location, phenotype, and function still are debated. Gaucher disease (GD) is caused by a geneti
Autor:
Tom Wennekes, Alfred J. Meijer, Albert K. Groen, Rolf G. Boot, Johanna E. Groener, Marco van Eijk, Roelof Ottenhoff, Nora Bijl, Karen Ghauharali, Hang Song, Tom J. OâShea, Hanlan Liu, Nelson Yew, Diane Copeland, Richard J. van den Berg, Gijsbert A. van der Marel, Herman S. Overkleeft, Johannes M. Aerts
Publikováno v:
Journal of Medicinal Chemistry; Jan2010, Vol. 53 Issue 2, p689-698, 10p