Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Johannes M Dijkstra"'
Autor:
Takuma Asahi, Shinya Abe, Guangwei Cui, Akihiro Shimba, Tsukasa Nabekura, Hitoshi Miyachi, Satsuki Kitano, Keizo Ohira, Johannes M Dijkstra, Masaki Miyazaki, Akira Shibuya, Hiroshi Ohno, Koichi Ikuta
Publikováno v:
eLife, Vol 12 (2023)
Group 1 innate lymphoid cells (G1-ILCs), including circulating natural killer (NK) cells and tissue-resident type 1 ILCs (ILC1s), are innate immune sentinels critical for responses against infection and cancer. In contrast to relatively uniform NK ce
Externí odkaz:
https://doaj.org/article/abc9b5a0b87d477e8e059f0cfa296e7f
Autor:
Craig E Hughes, Uvaraj P Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M Dijkstra, Pudur Jagadeeswaran, Stephen P Watson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52622 (2012)
Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM). Cross-linking of GPVI mediates activation through the
Externí odkaz:
https://doaj.org/article/69db605b94a6406889eea7ca5ef74c09
Autor:
Tamae Ohye, Hiromu Takematsu, Johannes M. Dijkstra, Itsuro Katsuda, Hidehiko Akiyama, Taei Matsui, Atsushi Ogasawara, Yuki Higashimoto, Seiji Imamura, Hiroki Doi
Publikováno v:
F1000Research, Vol 10 (2022)
Background: Andrographolide (Andro) is a diterpenoid component of the plant Andrographis paniculata that is known for its anti-tumor activity against a variety of cancer cells. Methods: We studied the effects of Andro on the viability of the human le
Externí odkaz:
https://doaj.org/article/8e9d01f93fd94edc9397fc1cf7d4af83
Autor:
Tamae Ohye, Hiromu Takematsu, Johannes M. Dijkstra, Itsuro Katsuda, Hidehiko Akiyama, Taei Matsui, Atsushi Ogasawara, Yuki Higashimoto, Seiji Imamura, Hiroki Doi
Publikováno v:
F1000Research, Vol 10 (2021)
Background: Andrographolide (Andro) is a diterpenoid component of the plant Andrographis paniculata that is known for its anti-tumor activity against a variety of cancer cells. Methods: We studied the effects of Andro on the viability of the human le
Externí odkaz:
https://doaj.org/article/c33968b045ed473d9bdbfa000cca910c
Autor:
Peter Riederer, Toshiharu Nagatsu, Moussa B. H. Youdim, Max Wulf, Johannes M. Dijkstra, Jeswinder Sian-Huelsmann
Publikováno v:
Journal of Neural Transmission. 130:627-646
Since the description of some peculiar symptoms by James Parkinson in 1817, attempts have been made to define its cause or at least to enlighten the pathology of “Parkinson’s disease (PD).” The vast majority of PD subtypes and most cases of spo
Autor:
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A. Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, Johannes M. Dijkstra
Publikováno v:
Journal of Neural Transmission. 130:611-625
The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in the human brain. During the progression of Parkinson’s disease (PD),
Autor:
Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J. Secombes, Azusa Kimoto, Mitsuru Furihata, Keiichiro Hashimoto, Uwe Fischer, Johannes M. Dijkstra
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Related interleukin-2, -15, and -15-like (IL-2, -15, and -15L) are ancient cytokines, with all three genes surviving in extant fish and some mammals. The present study is the first to identify IL-15L functions, namely in rainbow trout. In isolated tr
Externí odkaz:
https://doaj.org/article/a04ed1f2d99c4c5683173a9e4b33dc62
Autor:
Youhei Nashimoto, Fumio Matsushita, Johannes M. Dijkstra, Yuta Nakamura, Hidehiko Akiyama, Jiharu Hamako, Takashi Morita, Satohiko Araki, Taei Matsui
Publikováno v:
Toxins, Vol 14, Iss 4, p 236 (2022)
Bitiscetin-1 (aka bitiscetin) and bitiscetin-2 are C-type lectin-like proteins purified from the venom of Bitis arietans (puff adder). They bind to von Willebrand factor (VWF) and—at least bitiscetin-1—induce platelet agglutination via enhancemen
Externí odkaz:
https://doaj.org/article/08fdf0a020cf4731888827071c17dd72
Publikováno v:
Biology, Vol 4, Iss 4, Pp 814-859 (2015)
A phenomenon already discovered more than 25 years ago is the possibility of naïve helper T cells to polarize into TH1 or TH2 populations. In a simplified model, these polarizations occur at opposite ends of an “immune 1-2 axis” (i1-i2 axis) of
Externí odkaz:
https://doaj.org/article/e91f382c103d4d979fb047b00811f845
Publikováno v:
Journal of Neural Transmission. 129:805-828