Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Johannes Loffing"'
Autor:
Zheng Fan, Mara Karakone, Shunmugam Nagarajan, Nadine Nagy, Wiebke Mildenberger, Ekaterina Petrova, Laura Catharina Hinte, Mitchell Bijnen, Philipp Häne, Eric Nelius, Jing Chen, Irina Ferapontova, Ferdinand von Meyenn, Francesco Trepiccione, Mesut Berber, David Penton Ribas, Anne Eichmann, Maria-Christina Zennaro, Norihiko Takeda, Jens W. Fischer, Ariadni Spyroglou, Martin Reincke, Felix Beuschlein, Johannes Loffing, Melanie Greter, Christian Stockmann
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114395- (2024)
Summary: Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preser
Externí odkaz:
https://doaj.org/article/02b69b219d364673aaf81f6bfedf2bb0
Autor:
Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V. Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T. Breault, David Penton
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low p
Externí odkaz:
https://doaj.org/article/17c862d14a5b4e46b23bf19918c8d968
Autor:
Alessia Spirli, Lydie Cheval, Anne Debonneville, David Penton, Caroline Ronzaud, Marc Maillard, Alain Doucet, Johannes Loffing, Olivier Staub
Publikováno v:
Physiological Reports, Vol 7, Iss 15, Pp n/a-n/a (2019)
Abstract The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in the aldosterone‐sensitive distal nephron (ASDN) and stimulating a complex transcri
Externí odkaz:
https://doaj.org/article/297fa8daf6ae48448175fc678497a2ab
Autor:
Matthias Braun, James Young, Cäcilia S Reiner, Diane Poster, Fabienne Krauer, Andreas D Kistler, Paulus Kristanto, Xueqi Wang, Yang Liu, Johannes Loffing, Gustav Andreisek, Arnold von Eckardstein, Oliver Senn, Rudolf P Wüthrich, Andreas L Serra
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45868 (2012)
Sirolimus has been approved for clinical use in non proliferative and proliferative disorders. It inhibits the mammalian target of rapamycin (mTOR) signaling pathway which is also known to regulate ovarian morphology and function. Preliminary observa
Externí odkaz:
https://doaj.org/article/d17e7527a33940d88e7af13e3155ed3b
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F446-F460
The renal thick ascending limb (TAL) is critical for renal control of fluid and ion homeostasis. However, the underlying molecular mechanisms that regulate TAL function are incompletely understood. This study describes a novel transgenic mouse model
Autor:
Ganesh Pathare, Klaudia Kopper, Adisa Trnjanin, Dominique Loffing-Cueni, Agnieszka Wengi, Johannes Loffing
Publikováno v:
Physiology. 38
Soluble-Klotho (sKl) is the shed ectodomain of the transmembrane protein-Klotho (mKl) that exhibits pleiotropic actions, including lifespan extension, mineral metabolism, slowing-down kidney diseases and cardioprotection. The sKl is derived from the
Autor:
Søren Poulsen, Sara Baungaard, Laurent Bourqui, Sathish Murali, Rikke Nørregaard, Johannes Loffing, Robert Fenton
Publikováno v:
Physiology. 38
Introduction: Glucagon is raised during hypoglycemia in order to bring blood glucose back to normal levels. However, glucagon is paradoxically also raised under pathophysiological conditions where plasma glucose is high such as in diabetes mellitus (
Autor:
Truyen D, Pham, Anthony J, Elengickal, Jill W, Verlander, Lama, Al-Qusairi, Chao, Chen, Delaney C, Abood, Spencer A, King, Johannes, Loffing, Paul A, Welling, Susan M, Wall
Publikováno v:
Am J Physiol Renal Physiol
Pendrin is an intercalated cell Cl(−)/ [Formula: see text] exchanger thought to participate in K(+)-sparing NaCl absorption. However, its role in K(+) homeostasis has not been clearly defined. We hypothesized that pendrin-null mice will develop hyp
Autor:
Truyen D. Pham, Anthony J. Elengickal, Jill W. Verlander, Lama Al-Qusairi, Chao Chen, Delaney C. Abood, Spencer A. King, Johannes Loffing, Paul A. Welling, Susan M. Wall
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F486-F497
Pendrin is an apical Cl−/[Formula: see text] exchanger that provides renal K+-sparing NaCl absorption. The pendrin-null kidney has an inability to fully conserve K+ and limits renal K+ loss by downregulating the epithelial Na+ channel (ENaC). Howev
Autor:
Johannes Loffing, Robert Little, Søren Brandt Poulsen, Sathish K. Murali, Marleen L. A. Kortenoeven, Lei Cheng, Robert A. Fenton, David Penton, Vladimir V. Matchkov
Publikováno v:
Poulsen, S B, Cheng, L, Penton, D, Kortenoeven, M L A, Matchkov, V V, Loffing, J, Little, R, Murali, S K & Fenton, R A 2021, ' Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure ', Kidney International, vol. 100, no. 2, pp. 321-335 . https://doi.org/10.1016/j.kint.2021.04.021
The thiazide-sensitive sodium-chloride-cotransporter (NCC) in the kidney distal convoluted tubule (DCT) plays an essential role in sodium and potassium homeostasis. Here, we demonstrate that NCC activity is increased by the β2-adrenoceptor agonist s