Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Johannes Kuehle"'
Autor:
Jamal Alzubi, Viviane Dettmer-Monaco, Johannes Kuehle, Niko Thorausch, Maximilian Seidl, Sanaz Taromi, Wolfgang Schamel, Robert Zeiser, Hinrich Abken, Toni Cathomen, Philipp Wolf
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 226-235 (2020)
While chimeric antigen receptor (CAR) T cell immunotherapy targeting CD19 has shown remarkable success in patients with lymphoid malignancies, the potency of CAR T cells in solid tumors is low so far. To improve the efficacy of CAR T cells targeting
Externí odkaz:
https://doaj.org/article/da969265138c4086a127a5b413c0ca52
Autor:
Loreen Sophie Rudek, Katharina Zimmermann, Melanie Galla, Johann Meyer, Johannes Kuehle, Andriana Stamopoulou, Daniel Brand, I. Erol Sandalcioglu, Belal Neyazi, Thomas Moritz, Claudia Rossig, Bianca Altvater, Christine S. Falk, Hinrich Abken, Michael Alexander Morgan, Axel Schambach
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune cell therapeutics are increasingly applied in oncology. Especially chimeric antigen receptor (CAR) T cells are successfully used to treat several B cell malignancies. Efforts to engineer CAR T cells for improved activity against solid tumors i
Externí odkaz:
https://doaj.org/article/2a54408c3f4a4724be8b0023202931c6
Autor:
Markus Chmielewski, Johannes Kuehle, Danuta Chrobok, Nicole Riet, Michael Hallek, Hinrich Abken
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract The demand for recombinant proteins for analytic and therapeutic purposes is increasing; however, most currently used bacterial production systems accumulate the recombinant proteins in the intracellular space, which requires denaturating pr
Externí odkaz:
https://doaj.org/article/6f5191feaea74029b69a14bd4e59208a
Autor:
Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://doaj.org/article/2595b6871a8e4673b10f1cd8093290c6
Autor:
Daniela Paasch, Johann Meyer, Andriana Stamopoulou, Daniela Lenz, Johannes Kuehle, Doreen Kloos, Theresa Buchegger, Astrid Holzinger, Christine S. Falk, Christina Kloth, Constantin S. von Kaisenberg, Hinrich Abken, Axel Schambach, Nico Lachmann, Michael Morgan, Thomas Moritz
Publikováno v:
Cells, Vol 11, Iss 6, p 994 (2022)
Chimeric antigen receptor (CAR) T-cell therapies have shown impressive results in patients with hematological malignancies; however, little success has been achieved in the treatment of solid tumors. Recently, macrophages (MΦs) were identified as an
Externí odkaz:
https://doaj.org/article/43d3b295b9ed4b2f841abfe2582e903a
Autor:
Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff, Axel Schambach
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retro
Externí odkaz:
https://doaj.org/article/90f7e4752ff0410b8c88e36b068c3079
Autor:
Shamim H Rahman, Johannes Kuehle, Christian Reimann, Tafadzwa Mlambo, Jamal Alzubi, Morgan L Maeder, Heimo Riedel, Paul Fisch, Tobias Cantz, Cornelia Rudolph, Claudio Mussolino, J Keith Joung, Axel Schambach, Toni Cathomen
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005239 (2015)
In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate iPSCs into affected cell typ
Externí odkaz:
https://doaj.org/article/1408d426c90e4ba8a6c9198e7e74e645
Autor:
Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff, Axel Schambach
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-1 (2017)
Abstract The authors wish to apologize for an error within the scale bar of the microarray heatmap in Additional File 5 of the supplementary information. Two values were incorrectly displayed on the scale bar (11 instead of 10 and 13 instead of 12).
Externí odkaz:
https://doaj.org/article/468caf7c20f94eb6a420a81544380f41
Autor:
Toni Cathomen, Philipp Wolf, Sanaz Taromi, Wolfgang W. A. Schamel, Maximilian Seidl, Hinrich Abken, Niko Thorausch, Jamal Alzubi, Robert Zeiser, Johannes Kuehle, Viviane Dettmer-Monaco
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 226-235 (2020)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
While chimeric antigen receptor (CAR) T cell immunotherapy targeting CD19 has shown remarkable success in patients with lymphoid malignancies, the potency of CAR T cells in solid tumors is low so far. To improve the efficacy of CAR T cells targeting
Autor:
Julia Skokowa, Dirk Hoffmann, Nico Lachmann, Daniela Zychlinski, Friederike Philipp, Daniela Lenz, Thomas Moritz, Axel Schambach, Doris Steinemann, Johannes Kuehle, Michael A. Morgan, Christoph Klein
Publikováno v:
Gene Therapy. 27:297-306
Induced pluripotent stem cells (iPSCs) from patients with genetic disorders are a valuable source for in vitro disease models, which enable drug testing and validation of gene and cell therapies. We generated iPSCs from a severe congenital neutropeni