Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Johannes Khinast"'
Autor:
Ivan Vidakovic, Karin Kornmueller, Daniela Fiedler, Johannes Khinast, Eleonore Fröhlich, Gerd Leitinger, Christina Horn, Julian Quehenberger, Oliver Spadiut, Ruth Prassl
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 694 (2024)
Archaeosomes were manufactured from natural archaeal lipids by a microfluidics-assisted single-step production method utilizing a mixture of di- and tetraether lipids extracted from Sulfolobus acidocaldarius. The primary aim of this study was to inve
Externí odkaz:
https://doaj.org/article/00ad565ec1f545ef87eb8dcaffeb86ae
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2592 (2023)
Developing delayed-release formulations for acid-sensitive actives can be a costly and time-consuming process. However, ready-to-fill functional capsules, such as EUDRACAP® can significantly mitigate these challenges. The in vitro performance of EUD
Externí odkaz:
https://doaj.org/article/2c2c02b313c843afb7fb155e2bee8552
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100084- (2021)
Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality. To this end, we studied the influence of process settin
Externí odkaz:
https://doaj.org/article/934bfc52759b4cbf95789c268a659fed
Autor:
Josip Matić, Carolina Alva, Andreas Witschnigg, Simone Eder, Kathrin Reusch, Amrit Paudel, Johannes Khinast
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100062- (2020)
In product development, it is crucial to choose the appropriate drug manufacturing route accurately and timely and to ensure that the technique selected is suitable for achieving the desired product quality. Guided by the QbD principles, the pharmace
Externí odkaz:
https://doaj.org/article/f92f6e0b15ac4b12bfd66c3acc6ee7f0
Autor:
Peter Toson, Diogo G. Lopes, Raphael Paus, Ashish Kumar, Jeroen Geens, Sandy Stibale, Julian Quodbach, Peter Kleinebudde, Wen-Kai Hsiao, Johannes Khinast
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experiments as inpu
Externí odkaz:
https://doaj.org/article/dfd576819c1341e6aa81340b5843143e
Autor:
Martin Spoerk, Ioannis Koutsamanis, Josip Matić, Simone Eder, Carolina Patricia Alva Zúñiga, Johannes Poms, Jesús Alberto Afonso Urich, Raymar Andreína Lara García, Klaus Nickisch, Karin Eggenreich, Andreas Berghaus, Kathrin Reusch, Yorick Relle, Johannes Khinast, Amrit Paudel
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 588 (2020)
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity
Externí odkaz:
https://doaj.org/article/68264e93ced746988a89d9fb178a2e77
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 452 (2020)
Continuously operated pharmaceutical manufacturing lines often consist of a wet granulation unit operation, followed by a (semi-) continuous dryer. The operating conditions of the dryer are crucial for obtaining a desired final granule moisture. Comm
Externí odkaz:
https://doaj.org/article/90f35ffcf3d147c0889eb492e7bcaa7c
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 101 (2018)
Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid sample
Externí odkaz:
https://doaj.org/article/612f443cc561470b89e008ab4885c5fc
Publikováno v:
Journal of Real-Time Image Processing. 19:881-892
Publikováno v:
Biotechnology and Bioengineering. 119:2494-2504
In high-performance industrial fermentation processes, stirring and aeration may account for significant production costs. Compared to the widely applied Rushton impellers, axial-pumping impellers are known to yield a lower power draw and at the same