Výsledky vyhledávání - "Johannes Jungwirth"

Akademický článek

ProcCluster® and procaine hydrochloride inhibit the replication of influenza A virus in vitro

Autor: Clio Häring, Josefine Schroeder, Johannes Jungwirth, Bettina Löffler, Andreas Henke, Beatrice Engert, Christina Ehrhardt

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

IntroductionTreatment of influenza A virus infections is currently limited to few direct acting antiviral substances. Repurposing other established pharmaceuticals as antivirals could aid in improving treatment options.MethodsThis study investigates

Externí odkaz: https://doaj.org/article/15d0a6b4f4504e7989c9afeca142aa76

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Akademický článek

Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trialResearch in context

Autor: Robin von Rotz, Eva M. Schindowski, Johannes Jungwirth, Anna Schuldt, Nathalie M. Rieser, Katharina Zahoranszky, Erich Seifritz, Albina Nowak, Peter Nowak, Lutz Jäncke, Katrin H. Preller, Franz X. Vollenweider

Publikováno v: EClinicalMedicine, Vol 56, Iss , Pp 101809- (2023)

Summary: Background: Psilocybin has been suggested as a novel, rapid-acting treatment for depression. Two consecutive doses have been shown to markedly decrease symptom severity in an open-label setting or when compared to a waiting list group. To da

Externí odkaz: https://doaj.org/article/1c6fbc66a08545449e6676d431b95c61

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D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir

Autor: Ehrhardt, Johannes Jungwirth, Clio Häring, Sarah König, Liane Giebeler, Heena Doshi, Christian Brandt, Stefanie Deinhardt-Emmer, Bettina Löffler, Christina

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 6880

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease-19 (COVID-19) is still challenging healthcare systems and societies worldwide. While vaccines are available, therapeutic strategies are developing and ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::1739da738d5f1cb12da94fcb1f2bf991

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D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir

Autor: Johannes, Jungwirth, Clio, Häring, Sarah, König, Liane, Giebeler, Heena, Doshi, Christian, Brandt, Stefanie, Deinhardt-Emmer, Bettina, Löffler, Christina, Ehrhardt

Publikováno v: International journal of molecular sciences. 23(13)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76c7d2a837ea3a21c20ade96c111135a
https://pubmed.ncbi.nlm.nih.gov/35805887

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Partial reduction in BRCA1 gene dose modulates DNA replication stress level and thereby contributes to sensitivity or resistance

Autor: Sandra Classen, Elena Rahlf, Johannes Jungwirth, Nina Albers, Luca Philipp Hebestreit, Alexandra Zielinski, Lena Poole, Marco Groth, Philipp Koch, Thomas Liehr, Stefanie Kankel, Nils Cordes, Cordula Petersen, Kai Rothkamm, Helmut Pospiech, Kerstin Borgmann

Publikováno v: Cancers 23(2022)21, 13363
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13363

BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the BRCA1 gene causing inferior survival of bre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336d537ed98414e15d07389733ae430
http://urn.fi/urn:nbn:fi-fe2023063068689

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SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

Publikováno v: Journal of Virology

SARS-CoV-2 challenges health care systems and societies worldwide in unprecedented ways. Although numerous new studies have been conducted, research to better understand the molecular pathogen-host interactions are urgently needed.
Infections wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024c208cb1dd122b10dd659b63dea2c6
https://pubmed.ncbi.nlm.nih.gov/33637603

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Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography

Autor: Dietmar Winkler, Verena Pichler, Thomas Stimpfl, Marie Spies, Mathis Godbersen, Marcus Hacker, Leo Silberbauer, Georg S. Kranz, Jakob Unterholzner, Gregor Gryglewski, Neydher Berroterán-Infante, Johannes Jungwirth, Birgit Reiter, Markus Mitterhauser, Marius Hienert, Siegfried Kasper, G.M. James, Harald Ibeschitz, Rupert Lanzenberger

Publikováno v: International Journal of Neuropsychopharmacology

Background Comprehensive description of ketamine’s molecular binding profile becomes increasingly pressing as use in real-life patient cohorts widens. Animal studies attribute a significant role in the substance’s antidepressant effects to the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032da914fcb16ce6aec3b8576f6a2b28
https://doi.org/10.1093/ijnp/pyx085

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